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Research ArticleNew Research, Disorders of the Nervous System

Dynamic and Sex-Specific Changes in Gonadotropin-Releasing Hormone Neuron Activity and Excitability in a Mouse Model of Temporal Lobe Epilepsy

Jiang Li, Jordyn A. Robare, Liying Gao, M. Amin Ghane, Jodi A. Flaws, Mark E. Nelson and Catherine A. Christian
eNeuro 11 September 2018, 5 (5) ENEURO.0273-18.2018; https://doi.org/10.1523/ENEURO.0273-18.2018
Jiang Li
1Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Jordyn A. Robare
2Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Liying Gao
3Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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M. Amin Ghane
2Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Jodi A. Flaws
3Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Mark E. Nelson
1Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801
2Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
4Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Catherine A. Christian
1Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801
2Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
4Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0273-18.2018
PubMed 
30255128
Published By 
Society for Neuroscience
History 
  • Received July 9, 2018
  • Revision received September 4, 2018
  • Accepted September 5, 2018
  • Published online September 11, 2018.
Copyright & Usage 
Copyright © 2018 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jiang Li1,
  2. Jordyn A. Robare2,
  3. Liying Gao3,
  4. M. Amin Ghane2,
  5. Jodi A. Flaws3,
  6. Mark E. Nelson1,2,4 and
  7. Catherine A. Christian1,2,4
  1. 1Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801
  2. 2Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
  3. 3Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801
  4. 4Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
  1. Correspondence should be addressed to Catherine A. Christian, Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801. E-mail: cathchri{at}illinois.edu.
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Author contributions

  1. Author Contributions: J.L. and C.A.C. designed research; J.L., J.A.R., L.G., M.A.G., and J.A.F. performed research; J.L., M.E.N., and C.A.C. analyzed data; J.L. and C.A.C. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) grants R01 NS105825 and R03 NS103029 (C.A.C.), startup funds from the University of Illinois at Urbana-Champaign (C.A.C.), and a Beckman Institute Graduate Fellowship (J.L.).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01 NS105825; R03 NS103029
  • UofI | University of Illinois at Urbana-Champaign (UIUC)

    Startup Funds
  • Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign

    Graduate Fellowship

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  • previous version (September 11, 2018).
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Sep 20185442378
Oct 2018806368151
Nov 201815813042
Dec 2018658229
Total 20181573603300
Jan 20193211215
Feb 20192213125
Mar 20191219916
Apr 20191532376
May 20191520318
Jun 20191710516
Jul 20191325219
Aug 20191942525
Oct 2019937425
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Total 20191642552260
Jan 2020106410
Feb 202086423
Mar 202035310
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Aug 202043711
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Nov 202028121
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Total 202042788178
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Feb 20215586
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Apr 20217559
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Jun 202109014
Jul 202138124
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Total 202137858197
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Feb 202217114
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Total 202224688203
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Total 202326619199
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Jun 2025127720
Jul 2025206037
Aug 2025165054
Sep 20251612613
Oct 202597339
Nov 202523811
Total 202592810261
Total201376061858
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Dynamic and Sex-Specific Changes in Gonadotropin-Releasing Hormone Neuron Activity and Excitability in a Mouse Model of Temporal Lobe Epilepsy
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Dynamic and Sex-Specific Changes in Gonadotropin-Releasing Hormone Neuron Activity and Excitability in a Mouse Model of Temporal Lobe Epilepsy
Jiang Li, Jordyn A. Robare, Liying Gao, M. Amin Ghane, Jodi A. Flaws, Mark E. Nelson, Catherine A. Christian
eNeuro 11 September 2018, 5 (5) ENEURO.0273-18.2018; DOI: 10.1523/ENEURO.0273-18.2018

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Dynamic and Sex-Specific Changes in Gonadotropin-Releasing Hormone Neuron Activity and Excitability in a Mouse Model of Temporal Lobe Epilepsy
Jiang Li, Jordyn A. Robare, Liying Gao, M. Amin Ghane, Jodi A. Flaws, Mark E. Nelson, Catherine A. Christian
eNeuro 11 September 2018, 5 (5) ENEURO.0273-18.2018; DOI: 10.1523/ENEURO.0273-18.2018
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Keywords

  • excitability
  • GnRH
  • hormone
  • patch clamp electrophysiology
  • temporal lobe epilepsy

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