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Research ArticleNew Research, Disorders of the Nervous System

Carriage of Supernumerary Sex Chromosomes Decreases the Volume and Alters the Shape of Limbic Structures

Ajay Nadig, Paul K. Reardon, Jakob Seidlitz, Cassidy L. McDermott, Jonathan D. Blumenthal, Liv S. Clasen, Francois Lalonde, Jason P. Lerch, M. Mallar Chakravarty and Armin Raznahan
eNeuro 19 October 2018, 5 (5) ENEURO.0265-18.2018; DOI: https://doi.org/10.1523/ENEURO.0265-18.2018
Ajay Nadig
1Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
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Paul K. Reardon
1Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
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Jakob Seidlitz
1Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
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Cassidy L. McDermott
1Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
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Jonathan D. Blumenthal
1Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
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Liv S. Clasen
1Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
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Francois Lalonde
1Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
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Jason P. Lerch
2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5T 1R8, Canada
3Neurosciences and Mental Health, the Hospital for Sick Children, Toronto, Ontario M5T 3H7, Canada
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M. Mallar Chakravarty
4Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H3A OG4, Canada
5Department of Psychiatry, McGill University, Montreal, Quebec H3A OG4, Canada
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Armin Raznahan
1Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0265-18.2018
PubMed 
30713992
Published By 
Society for Neuroscience
History 
  • Received July 10, 2018
  • Revision received August 30, 2018
  • Accepted September 24, 2018
  • Published online October 19, 2018.
Copyright & Usage 
Copyright © 2018 Nadig et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ajay Nadig1,
  2. Paul K. Reardon1,
  3. Jakob Seidlitz1,
  4. Cassidy L. McDermott1,
  5. Jonathan D. Blumenthal1,
  6. Liv S. Clasen1,
  7. Francois Lalonde1,
  8. Jason P. Lerch2,3,
  9. M. Mallar Chakravarty4,5 and
  10. Armin Raznahan1
  1. 1Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
  2. 2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5T 1R8, Canada
  3. 3Neurosciences and Mental Health, the Hospital for Sick Children, Toronto, Ontario M5T 3H7, Canada
  4. 4Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H3A OG4, Canada
  5. 5Department of Psychiatry, McGill University, Montreal, Quebec H3A OG4, Canada
  1. Correspondence should be addressed to Dr. Armin Raznahan, National Institute of Mental Health, Bethesda, Maryland 20892. E-mail: raznahana{at}mail.nih.gov.
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Author contributions

  1. Author contributions: A.N. and A.R. designed research; A.N., C.L.M., J.D.B., L.S.C., F.L., and A.R. performed research; A.N., P.K.R., J.S., and A.R. analyzed data; A.N. and A.R. wrote the paper; J.P.L. and M.M.C. contributed unpublished reagents/analytic tools.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the intramural program of the National Institutes of Health (Clinical trial NCT00001246, clinicaltrials.gov; NIH Annual Report Number, ZIA MH002794-13). P.K.R. and J.S. are supported by the NIH Oxford-Cambridge Scholars’ Program. A.N. and C.S. are supported by NIH Intramural Research Training Awards. We thank the patients and their families for their participation in this study.

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    ZIA MH002794-13

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  • previous version (October 19, 2018).

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Oct 2018159032
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Total 20183385779
Jan 2019374011
Feb 20192220117
Mar 20191227411
Apr 201982098
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Jun 201972648
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Aug 20191082822
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Aug 20211538
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Total 202119760159
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Carriage of Supernumerary Sex Chromosomes Decreases the Volume and Alters the Shape of Limbic Structures
Ajay Nadig, Paul K. Reardon, Jakob Seidlitz, Cassidy L. McDermott, Jonathan D. Blumenthal, Liv S. Clasen, Francois Lalonde, Jason P. Lerch, M. Mallar Chakravarty, Armin Raznahan
eNeuro 19 October 2018, 5 (5) ENEURO.0265-18.2018; DOI: 10.1523/ENEURO.0265-18.2018

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Carriage of Supernumerary Sex Chromosomes Decreases the Volume and Alters the Shape of Limbic Structures
Ajay Nadig, Paul K. Reardon, Jakob Seidlitz, Cassidy L. McDermott, Jonathan D. Blumenthal, Liv S. Clasen, Francois Lalonde, Jason P. Lerch, M. Mallar Chakravarty, Armin Raznahan
eNeuro 19 October 2018, 5 (5) ENEURO.0265-18.2018; DOI: 10.1523/ENEURO.0265-18.2018
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Keywords

  • amygdala
  • CNV
  • Hippocampus
  • sex chromosome aneuploidy

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