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Research ArticleNew Research, Integrative Systems

Role of the K+-Cl– Cotransporter KCC2a Isoform in Mammalian Respiration at Birth

Christophe J. Dubois, Laura Cardoit, Veronika Schwarz, Marika Markkanen, Matti S. Airaksinen, Pavel Uvarov, John Simmers and Muriel Thoby-Brisson
eNeuro 4 October 2018, 5 (5) ENEURO.0264-18.2018; https://doi.org/10.1523/ENEURO.0264-18.2018
Christophe J. Dubois
1Institut de Neurosciences Cognitives et Intégratives D’Aquitaine, CNRS UMR 5287, Université de Bordeaux, Bordeaux 33076, France
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Laura Cardoit
1Institut de Neurosciences Cognitives et Intégratives D’Aquitaine, CNRS UMR 5287, Université de Bordeaux, Bordeaux 33076, France
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Veronika Schwarz
1Institut de Neurosciences Cognitives et Intégratives D’Aquitaine, CNRS UMR 5287, Université de Bordeaux, Bordeaux 33076, France
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Marika Markkanen
2Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki Finland
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Matti S. Airaksinen
2Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki Finland
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Pavel Uvarov
2Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki Finland
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John Simmers
1Institut de Neurosciences Cognitives et Intégratives D’Aquitaine, CNRS UMR 5287, Université de Bordeaux, Bordeaux 33076, France
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Muriel Thoby-Brisson
1Institut de Neurosciences Cognitives et Intégratives D’Aquitaine, CNRS UMR 5287, Université de Bordeaux, Bordeaux 33076, France
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0264-18.2018
PubMed 
30406192
Published By 
Society for Neuroscience
History 
  • Received July 6, 2018
  • Revision received September 15, 2018
  • Accepted September 17, 2018
  • Published online October 4, 2018.
Copyright & Usage 
Copyright © 2018 Dubois et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Christophe J. Dubois1,*,
  2. Laura Cardoit1,*,
  3. Veronika Schwarz1,*,
  4. Marika Markkanen2,
  5. Matti S. Airaksinen2,
  6. Pavel Uvarov2,
  7. John Simmers1 and
  8. Muriel Thoby-Brisson1
  1. 1Institut de Neurosciences Cognitives et Intégratives D’Aquitaine, CNRS UMR 5287, Université de Bordeaux, Bordeaux 33076, France
  2. 2Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki Finland
  1. Address correspondence to Muriel Thoby-Brisson, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, CNRS UMR 5287, Université de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France. E-mail: muriel.thoby-brisson{at}u-bordeaux.fr.
  • Present address: Veronika Schwarz, Cell Biology/Anatomy III, Biomedical Center, Ludwig-Maximilians University Munich, Planegg-Martinsried, Germany. Pavel Uvarov, Molecular and Integrative Biosciences Research Program, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.

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Author contributions

  1. Author contributions: J.S., P.U., and M.T.-B. designed research; C.J.D., L.C., V.S., M.M., and M.T.-B. performed research and analyzed data; P.U., M.S.A., J.S., and M.T.-B. wrote the paper.

  2. ↵* C.J.D., L.C., and V.S. contributed equally to this paper.

  • Present address: Veronika Schwarz, Cell Biology/Anatomy III, Biomedical Center, Ludwig-Maximilians University Munich, Planegg-Martinsried, Germany. Pavel Uvarov, Molecular and Integrative Biosciences Research Program, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Agence Nationale de la Recherche (ANR12-BSV4-0011-01), an ‘Equipe FRM’ funding (DEQ20170336764) to M.T.-B., and by the Finnish Academy of Science (SA257312) to P.U.

Funding

  • Agence Nationale de la Recherche (ANR)

    ANR12-BSV4-0011-01
  • Fondation pour la Recherche Médicale

    DEQ20170336764
  • Finnish Academy of Science

    SA257312

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  • You are viewing the most recent version of this article.
  • previous version (October 04, 2018).

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Oct 201851974104
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Jan 202094113
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Jul 202587828
Aug 202566220
Sep 2025210717
Oct 2025107537
Nov 2025207812
Dec 2025136931
Total 202579804211
Jan 2026126125
Total 2026126125
Total125751901137
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Role of the K+-Cl– Cotransporter KCC2a Isoform in Mammalian Respiration at Birth
Christophe J. Dubois, Laura Cardoit, Veronika Schwarz, Marika Markkanen, Matti S. Airaksinen, Pavel Uvarov, John Simmers, Muriel Thoby-Brisson
eNeuro 4 October 2018, 5 (5) ENEURO.0264-18.2018; DOI: 10.1523/ENEURO.0264-18.2018

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Role of the K+-Cl– Cotransporter KCC2a Isoform in Mammalian Respiration at Birth
Christophe J. Dubois, Laura Cardoit, Veronika Schwarz, Marika Markkanen, Matti S. Airaksinen, Pavel Uvarov, John Simmers, Muriel Thoby-Brisson
eNeuro 4 October 2018, 5 (5) ENEURO.0264-18.2018; DOI: 10.1523/ENEURO.0264-18.2018
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Keywords

  • apnea
  • breathing
  • KCC2a
  • neural network
  • rhythmogenesis

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