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Research ArticleNew Research, Disorders of the Nervous System

Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex

Megan L. Slaker, Emily T. Jorgensen, Deborah M. Hegarty, Xinyue Liu, Yan Kong, Fuming Zhang, Robert J. Linhardt, Travis E. Brown, Sue A. Aicher and Barbara A. Sorg
eNeuro 1 October 2018, 5 (5) ENEURO.0221-18.2018; https://doi.org/10.1523/ENEURO.0221-18.2018
Megan L. Slaker
1Department of Integrative Physiology and Neuroscience, Translational Addiction Research Center, Washington State University, Vancouver, Washington 98686
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Emily T. Jorgensen
3School of Pharmacy and Department of Neuroscience, University of Wyoming, Laramie, Wyoming 82071
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Deborah M. Hegarty
2Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239
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Xinyue Liu
4Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180
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Yan Kong
4Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180
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  • ORCID record for Yan Kong
Fuming Zhang
4Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180
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Robert J. Linhardt
4Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180
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Travis E. Brown
3School of Pharmacy and Department of Neuroscience, University of Wyoming, Laramie, Wyoming 82071
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Sue A. Aicher
2Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239
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Barbara A. Sorg
1Department of Integrative Physiology and Neuroscience, Translational Addiction Research Center, Washington State University, Vancouver, Washington 98686
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0221-18.2018
PubMed 
30294670
Published By 
Society for Neuroscience
History 
  • Received June 4, 2018
  • Revision received September 6, 2018
  • Accepted September 13, 2018
  • Published online October 1, 2018.
Copyright & Usage 
Copyright © 2018 Slaker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Megan L. Slaker1,
  2. Emily T. Jorgensen3,
  3. Deborah M. Hegarty2,
  4. Xinyue Liu4,
  5. Yan Kong4,
  6. Fuming Zhang4,
  7. Robert J. Linhardt4,
  8. Travis E. Brown3,
  9. Sue A. Aicher2 and
  10. Barbara A. Sorg1
  1. 1Department of Integrative Physiology and Neuroscience, Translational Addiction Research Center, Washington State University, Vancouver, Washington 98686
  2. 2Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239
  3. 3School of Pharmacy and Department of Neuroscience, University of Wyoming, Laramie, Wyoming 82071
  4. 4Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180
  1. Correspondence should be addressed to Barbara A. Sorg, Department of Integrative Physiology and Neuroscience, Washington State University, Vancouver, WA 98686. E-mail: barbsorg{at}wsu.edu.
View Full Text

Author contributions

  1. Author contributions: F.Z., R.J.L., T.E.B., S.A.A., and B.A.S. designed research; M.L.S., E.T.J., D.M.H., X.L., and Y.K. performed research; T.E.B., S.A.A., and B.A.S. analyzed data; M.L.S., E.T.J., F.Z., R.J.L., T.E.B., and B.A.S. wrote the paper.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants DA-033404 and DA-040965 (B.A.S.); DA-040965 and P30-GM-103398 (T.E.B.); P30-NS-061800 (S.A.A.); and NIH-DK-111958 and HL-125371 (R.J.L.).

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    033404; 040965; 040965
  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    103398
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    061800
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    111958
  • HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

    125371

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Oct 20181948568179
Nov 201868531055
Dec 201847323924
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Feb 20192633111
Mar 20191935811
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Jun 20191131010
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Total 20192695120219
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Total 202045892274
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Jun 202219321
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Total 2023601782347
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May 2025810325
Jun 20252013241
Jul 20251310535
Aug 2025187336
Sep 20253218930
Oct 20252311736
Nov 20253113130
Dec 20252211345
Total 20251941327362
Jan 20261715125
Feb 20261824620
Total 20263539745
Total3884137622414
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Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex
Megan L. Slaker, Emily T. Jorgensen, Deborah M. Hegarty, Xinyue Liu, Yan Kong, Fuming Zhang, Robert J. Linhardt, Travis E. Brown, Sue A. Aicher, Barbara A. Sorg
eNeuro 1 October 2018, 5 (5) ENEURO.0221-18.2018; DOI: 10.1523/ENEURO.0221-18.2018

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Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex
Megan L. Slaker, Emily T. Jorgensen, Deborah M. Hegarty, Xinyue Liu, Yan Kong, Fuming Zhang, Robert J. Linhardt, Travis E. Brown, Sue A. Aicher, Barbara A. Sorg
eNeuro 1 October 2018, 5 (5) ENEURO.0221-18.2018; DOI: 10.1523/ENEURO.0221-18.2018
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Keywords

  • cocaine
  • interneurons
  • parvalbumin
  • perineuronal nets
  • prefrontal cortex

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