1A | Four-way RM ANOVA | N = 12 mice/group | Fday× surgery(6.40,255.89) = 3.801, p = 0.001 Fgenotype× surgery(1,40) = 15.173, p < 0.001 |
1B | Four-way RM ANOVA | N = 12 mice/group | Fday× genotype× surgery(5.99,233.65) = 2.138, p = 0.050 |
2A–D | Four-way RM ANOVA | N = 6–8 mice/group | Fregimen× sex× treatment group(3,62) = 4.181, p = 0.009 |
3A–D | Four-way RM ANOVA | N = 6 mice/group | Fsex× treatment group(4,62) = 2.888, p = 0.029 |
4A,B | Four-way ANOVA | N = 6 mice/group | Fsurgery(1,202) = 7.72, p = 0.006 Fsex(1,202) = 34.811, p < 0.001 |
4C,D | Four-way ANOVA | N = 6 mice/group | Fgenotype(1,253) = 7.882, p = 0.005 Fday× sex(4,253) = 2.555, p = 0.040 |
4E,F | Four-way ANOVA | N = 6 mice/group | Fday× genotype× sex(4,196) = 2.507, p = 0.043 Fsurgery(1,196) = 17.211, p < 0.001 |
4G,H | Four-way ANOVA | N = 6 mice/group | Fday(4,205) = 2.550, p = 0.040 |
5A,B | Four-way ANOVA | N = 6 mice/group | n.s., all ps > 0.05 |
5C,D | Four-way ANOVA | N = 6 mice/group | Fday× genotype× surgery× sex(4,206) = 2.607, p = 0.037 |
7A,B | Four-way ANOVA | N = 4 mice/group | Fday× surgery× side(4,148) = 18.667, p = 0.000 Fday× genotype× side(4,148) = 2.786, p = 0.029 |
8A,B | Four-way ANOVA | N = 4 mice/group | Fgenotype× surgery(1,144) = 4.202, p = 0.042 Fday× genotype× side(4,144) = 2.438, p = 0.050 |
8C,D | NA | N = 4 mice/group | Minimal colocalization; statistical analysis not possible |
8E,F | Four-way ANOVA | N = 4 mice/group | Fday× surgery(4,142) = 3.022, p = 0.020 |
8G | NA | N = 4 mice/group | Minimal colocalization; statistical analysis not possible |
9A,B | Four-way ANOVA | N = 4 mice/group | Fday(4,146) = 10.969, p < 0.001 |
9C,D | Four-way ANOVA | N = 4 mice/group | Fside(1,146) = 11.778, p = 0.001 |
9E,F | Four-way ANOVA | N = 4 mice/group | Fday× genotype× surgery(1,140) = 2.795, p = 0.028 |
9G,H | Four-way ANOVA | N = 4 mice/group | Fday× genotype× surgery× side(4,140) = 3.136, p = 0.017 |