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Research ArticleNew Research, Integrative Systems

The Role of Interleukin-10 in Mediating the Effect of Immune Challenge on Mouse Gonadotropin-Releasing Hormone Neurons In Vivo

Klaudia Barabás, Zsuzsanna Barad, Ádám Dénes, Janardhan P. Bhattarai, Seong-Kyu Han, Endre Kiss, Gabriella Sármay and István M. Ábrahám
eNeuro 27 September 2018, 5 (5) ENEURO.0211-18.2018; https://doi.org/10.1523/ENEURO.0211-18.2018
Klaudia Barabás
1MTA NAP-B Molecular Neuroendocrinology Research Group, Institute of Physiology, Medical School, Centre for Neuroscience, Szentágothai Research Institute, University of Pécs, 7624 Pécs, Hungary
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Zsuzsanna Barad
2Centre for Neuroendocrinology and Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
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Ádám Dénes
5Laboratory of Neuroimmunology, Hungarian Academy of Sciences, Institute of Experimental Medicine, Budapest 1119, Hungary
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Janardhan P. Bhattarai
3Department of Oral Physiololgy, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju 567, Republic of Korea
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Seong-Kyu Han
3Department of Oral Physiololgy, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju 567, Republic of Korea
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Endre Kiss
4Department of Immunology, Eötvös Loránd University, Budapest, Hungary
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Gabriella Sármay
4Department of Immunology, Eötvös Loránd University, Budapest, Hungary
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István M. Ábrahám
1MTA NAP-B Molecular Neuroendocrinology Research Group, Institute of Physiology, Medical School, Centre for Neuroscience, Szentágothai Research Institute, University of Pécs, 7624 Pécs, Hungary
2Centre for Neuroendocrinology and Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0211-18.2018
PubMed 
30406179
Published By 
Society for Neuroscience
History 
  • Received May 27, 2018
  • Revision received September 11, 2018
  • Accepted September 12, 2018
  • Published online September 27, 2018.
Copyright & Usage 
Copyright © 2018 Barabás et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Klaudia Barabás1,^,
  2. Zsuzsanna Barad2,^,
  3. Ádám Dénes5,
  4. Janardhan P. Bhattarai3,
  5. Seong-Kyu Han3,
  6. Endre Kiss4,
  7. Gabriella Sármay4 and
  8. István M. Ábrahám1,2
  1. 1MTA NAP-B Molecular Neuroendocrinology Research Group, Institute of Physiology, Medical School, Centre for Neuroscience, Szentágothai Research Institute, University of Pécs, 7624 Pécs, Hungary
  2. 2Centre for Neuroendocrinology and Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
  3. 3Department of Oral Physiololgy, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju 567, Republic of Korea
  4. 4Department of Immunology, Eötvös Loránd University, Budapest, Hungary
  5. 5Laboratory of Neuroimmunology, Hungarian Academy of Sciences, Institute of Experimental Medicine, Budapest 1119, Hungary
  1. Correspondence should be addressed to Dr. István M. Ábrahám, MTA NAP-B Molecular Neuroendocrinology Research Group, Institute of Physiology, Centre for Neuroscience, Medical School, Szentágothai Research Institute, University of Pécs, Pécs, Hungary, E-mail: istvan.abraham{at}aok.pte.hu.
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Author contributions

  1. Author contributions: I.M.A., K.B., and G.S. designed research; K.B., Z.B., E.K., S.-K.H., J.P.B., A.D. performed research; K.B., Z.B., I.M.A. analyzed data; I.M.A. and K.B. wrote the paper.

  2. ↵^ K.B. and Z.B. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Hungarian Brain Research Program (KTIA_NAP_13-2014-0001, 20017-1.2.1-NKP -2017-00002); National Science Fundation (112807); the Comprehensive Development for Implementing Smart Specialization Strategies at the University of Pécs (EFOP-3.6.1.-16-2016-00004); “The role of neuro-inflammation in neurodegeneration: from molecules to clinics” Ministry of Human Capacities; (EFOP-3.6.2-16-2017-00008), GINOP-2.3.2-15-2016-00048, Stay Alive; and the Otago School of Medical Sciences, Department of Physiology, University of Otago.

Funding

  • Hungarian Brain Research Program

    KTIA_NAP_13-2014-0001; 20017-1.2.1-NKP -2017-00002
  • Országos Tudományos Kutatási Alapprogramok (OTKA)

    112807
  • Comprehensive Development for Implementing Smart Specializations

    EFOP-3.6.1.-16-2016-00004
  • The role of neuro-inflammation

    EFOP-3.6.2-16-2017-00008
  • Stay Alive program

    GINOP-2.3.2-15-2016-00048

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 27, 2018).

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AbstractFullPdf
Sep 201894026
Oct 201859716688
Nov 20181387226
Dec 2018505326
Total 2018879291166
Jan 2019276121
Feb 2019299417
Mar 2019311709
Apr 20191120520
May 2019817317
Jun 20191011912
Jul 2019822111
Aug 2019932314
Oct 2019633431
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Dec 2019101547
Total 20191562085188
Jan 202045919
Feb 202062927
Mar 202032913
May 202022815
Jun 202043210
Jul 202021923
Aug 202001511
Sep 202033453
Oct 202047031
Nov 202046614
Dec 20205559
Total 202037436225
Jan 202165415
Feb 20213419
Mar 202165513
Apr 202105511
May 202145713
Jun 20212436
Jul 202134720
Aug 202114911
Sep 202104611
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Dec 20210534
Total 202129607153
Jan 20221588
Feb 202223720
Mar 202214918
Apr 20220288
May 202215217
Jun 20222507
Jul 20224289
Aug 202223012
Sep 202201612
Oct 202232816
Nov 202212614
Dec 202213311
Total 202218435152
Jan 202312811
Feb 20230349
Mar 20232449
Apr 20230477
May 202323516
Jun 20230401
Jul 202325116
Aug 202323726
Sep 202304520
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Total 202317517182
Jan 202414211
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Jul 202557818
Aug 202568113
Sep 2025913219
Oct 2025137921
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Dec 2025198725
Total 202592898193
Jan 202697419
Total 202697419
Total126758831419
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The Role of Interleukin-10 in Mediating the Effect of Immune Challenge on Mouse Gonadotropin-Releasing Hormone Neurons In Vivo
Klaudia Barabás, Zsuzsanna Barad, Ádám Dénes, Janardhan P. Bhattarai, Seong-Kyu Han, Endre Kiss, Gabriella Sármay, István M. Ábrahám
eNeuro 27 September 2018, 5 (5) ENEURO.0211-18.2018; DOI: 10.1523/ENEURO.0211-18.2018

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The Role of Interleukin-10 in Mediating the Effect of Immune Challenge on Mouse Gonadotropin-Releasing Hormone Neurons In Vivo
Klaudia Barabás, Zsuzsanna Barad, Ádám Dénes, Janardhan P. Bhattarai, Seong-Kyu Han, Endre Kiss, Gabriella Sármay, István M. Ábrahám
eNeuro 27 September 2018, 5 (5) ENEURO.0211-18.2018; DOI: 10.1523/ENEURO.0211-18.2018
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Keywords

  • ERK1/2
  • GnRH neurons
  • IL-10
  • immune challenge
  • T-cell-dependent B-cell response

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