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Research ArticleNew Research, Neuronal Excitability

Microglia Enhance Synapse Activity to Promote Local Network Synchronization

Ryohei Akiyoshi, Hiroaki Wake, Daisuke Kato, Hiroshi Horiuchi, Riho Ono, Ako Ikegami, Koichiro Haruwaka, Toshiaki Omori, Yoshihisa Tachibana, Andrew J. Moorhouse and Junichi Nabekura
eNeuro 11 October 2018, 5 (5) ENEURO.0088-18.2018; https://doi.org/10.1523/ENEURO.0088-18.2018
Ryohei Akiyoshi
1Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan 444-8585
2Department of Physiological Sciences, the Graduate School for Advanced Study, Hayama, Japan 240-0193
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Hiroaki Wake
3Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan 650-0017
6Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan 100-0004
7Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Japan 100-0004
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Daisuke Kato
1Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan 444-8585
3Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan 650-0017
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Hiroshi Horiuchi
1Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan 444-8585
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Riho Ono
3Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan 650-0017
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Ako Ikegami
3Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan 650-0017
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Koichiro Haruwaka
1Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan 444-8585
2Department of Physiological Sciences, the Graduate School for Advanced Study, Hayama, Japan 240-0193
3Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan 650-0017
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Toshiaki Omori
4Department of Electrical and Electronic Engineering, Graduate School of Engineering, Kobe University, Kobe, Japan 657-8501
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Yoshihisa Tachibana
3Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan 650-0017
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Andrew J. Moorhouse
5School of Medical Sciences, University of New South Wales, Sydney, Australia 2052
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Junichi Nabekura
1Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan 444-8585
2Department of Physiological Sciences, the Graduate School for Advanced Study, Hayama, Japan 240-0193
6Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan 100-0004
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0088-18.2018
PubMed 
30406198
Published By 
Society for Neuroscience
History 
  • Received March 6, 2018
  • Revision received September 17, 2018
  • Accepted September 22, 2018
  • Published online October 11, 2018.
Copyright & Usage 
Copyright © 2018 Akiyoshi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ryohei Akiyoshi1,2,
  2. Hiroaki Wake3,6,7,
  3. Daisuke Kato1,3,
  4. Hiroshi Horiuchi1,
  5. Riho Ono3,
  6. Ako Ikegami3,
  7. Koichiro Haruwaka1,2,3,
  8. Toshiaki Omori4,
  9. Yoshihisa Tachibana3,
  10. Andrew J. Moorhouse5 and
  11. Junichi Nabekura1,2,6
  1. 1Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan 444-8585
  2. 2Department of Physiological Sciences, the Graduate School for Advanced Study, Hayama, Japan 240-0193
  3. 3Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan 650-0017
  4. 4Department of Electrical and Electronic Engineering, Graduate School of Engineering, Kobe University, Kobe, Japan 657-8501
  5. 5School of Medical Sciences, University of New South Wales, Sydney, Australia 2052
  6. 6Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan 100-0004
  7. 7Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Japan 100-0004
  1. Correspondence should be addressed to either of the following: Dr. Hiroaki Wake, Professor Division of System Neuroscience, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan, E-mail: hirowake{at}med.kobe-u.ac.jp; or Dr. Junichi Nabekura, Professor Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 38 Myodaiji, Okazaki, 444-8585, Japan, E-mail: nabekura{at}nips.ac.jp.
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Author contributions

  1. Author contributions: H.W., J.N., A.J.M., and R.A. designed research; D.K., H.W., H.H., R.O., A.I., and R.A performed research; D.K., K.H., H.H., T.O., A.I., R.O., Y.T., and H.W., analyzed data; H.W., J.N., and A.J.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

Funding

  • Grant-in-Aid for Scientific research on Innovative Areas

    15H01300; 16H01346; 17H05747; and 25110732
  • Grant Aid for Young Scientist (A)

    26710004
  • JST | Core Research for Evolutional Science and Technology (CREST)

    JPMJCR1755
  • PRESTO

  • Grants in Aid for Scientific Research (B)

    18H02598

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 11, 2018).

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AbstractFullPdf
Oct 20189282501
Nov 2018335343208
Dec 201811617457
Total 20181379519766
Jan 20195818851
Feb 20192213324
Mar 20192516229
Apr 20191919653
May 20192015946
Jun 20191912435
Jul 20191415751
Aug 20191417466
Oct 2019711950
Nov 20191110951
Dec 20191514243
Total 20192241663499
Jan 20201115854
Feb 20201012555
Mar 2020118439
May 2020514656
Jun 2020416661
Jul 202048424
Aug 2020108223
Sep 2020713736
Oct 2020616569
Nov 2020513467
Dec 20201314956
Total 2020861430540
Jan 2021617670
Feb 2021411425
Mar 20211115055
Apr 2021615642
May 2021411841
Jun 2021110027
Jul 2021112444
Aug 2021514758
Sep 202127879
Oct 202189372
Nov 2021711742
Dec 202119930
Total 2021561472585
Jan 2022111041
Feb 2022514652
Mar 2022313750
Apr 202229145
May 2022213959
Jun 2022210429
Jul 202237831
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Sep 202218026
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Total 2022371215459
Jan 2023412728
Feb 202337728
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Apr 202327225
May 202346630
Jun 202339428
Jul 2023109942
Aug 2023138547
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Dec 2023511747
Total 2023831281415
Jan 20244013144
Feb 20243013246
Mar 20242714246
Apr 20242023355
May 20241613636
Jun 20241112533
Jul 20241013321
Aug 20241213652
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Total 20242181677467
Jan 20252412741
Feb 20251417830
Mar 20251714253
Apr 20251813129
May 2025916733
Jun 20251913847
Jul 20252917954
Aug 20252012374
Sep 20251514842
Oct 20251712244
Nov 20253313952
Dec 20251113847
Total 20252261732546
Jan 202645920
Total 202645920
Total2313110484297
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Microglia Enhance Synapse Activity to Promote Local Network Synchronization
Ryohei Akiyoshi, Hiroaki Wake, Daisuke Kato, Hiroshi Horiuchi, Riho Ono, Ako Ikegami, Koichiro Haruwaka, Toshiaki Omori, Yoshihisa Tachibana, Andrew J. Moorhouse, Junichi Nabekura
eNeuro 11 October 2018, 5 (5) ENEURO.0088-18.2018; DOI: 10.1523/ENEURO.0088-18.2018

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Microglia Enhance Synapse Activity to Promote Local Network Synchronization
Ryohei Akiyoshi, Hiroaki Wake, Daisuke Kato, Hiroshi Horiuchi, Riho Ono, Ako Ikegami, Koichiro Haruwaka, Toshiaki Omori, Yoshihisa Tachibana, Andrew J. Moorhouse, Junichi Nabekura
eNeuro 11 October 2018, 5 (5) ENEURO.0088-18.2018; DOI: 10.1523/ENEURO.0088-18.2018
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Keywords

  • calcium imaging
  • in vivo
  • microglia
  • synapse
  • two photon

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