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Research ArticleNew Research, Disorders of the Nervous System

Loss of Mecp2 Causes Atypical Synaptic and Molecular Plasticity of Parvalbumin-Expressing Interneurons Reflecting Rett Syndrome–Like Sensorimotor Defects

Noemi Morello, Riccardo Schina, Federica Pilotto, Mary Phillips, Riccardo Melani, Ornella Plicato, Tommaso Pizzorusso, Lucas Pozzo-Miller and Maurizio Giustetto
eNeuro 11 September 2018, 5 (5) ENEURO.0086-18.2018; https://doi.org/10.1523/ENEURO.0086-18.2018
Noemi Morello
1Department of Neuroscience, University of Turin, Corso M. D’Azeglio 52, Turin, 10126, Italy
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Riccardo Schina
1Department of Neuroscience, University of Turin, Corso M. D’Azeglio 52, Turin, 10126, Italy
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Federica Pilotto
1Department of Neuroscience, University of Turin, Corso M. D’Azeglio 52, Turin, 10126, Italy
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Mary Phillips
2Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
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Riccardo Melani
3Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Area San Salvi Pad. 26, Florence, 50135, Italy
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Ornella Plicato
1Department of Neuroscience, University of Turin, Corso M. D’Azeglio 52, Turin, 10126, Italy
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Tommaso Pizzorusso
3Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Area San Salvi Pad. 26, Florence, 50135, Italy
4Institute of Neuroscience, National Research Council (CNR), via Moruzzi 1, Pisa, 56124, Italy
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Lucas Pozzo-Miller
2Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
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Maurizio Giustetto
1Department of Neuroscience, University of Turin, Corso M. D’Azeglio 52, Turin, 10126, Italy
5National Institute of Neuroscience-Italy, Corso M. D’Azeglio 52, Turin, 10126, Italy
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0086-18.2018
PubMed 
30255129
Published By 
Society for Neuroscience
History 
  • Received December 21, 2017
  • Revision received July 27, 2018
  • Accepted August 2, 2018
  • Published online September 11, 2018.
Copyright & Usage 
Copyright © 2018 Morello et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Noemi Morello1,
  2. Riccardo Schina1,
  3. Federica Pilotto1,
  4. Mary Phillips2,
  5. Riccardo Melani3,
  6. Ornella Plicato1,
  7. Tommaso Pizzorusso3,4,
  8. Lucas Pozzo-Miller2 and
  9. Maurizio Giustetto1,5
  1. 1Department of Neuroscience, University of Turin, Corso M. D’Azeglio 52, Turin, 10126, Italy
  2. 2Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
  3. 3Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Area San Salvi Pad. 26, Florence, 50135, Italy
  4. 4Institute of Neuroscience, National Research Council (CNR), via Moruzzi 1, Pisa, 56124, Italy
  5. 5National Institute of Neuroscience-Italy, Corso M. D’Azeglio 52, Turin, 10126, Italy
  1. Correspondence should be addressed to Maurizio Giustetto, Dip. di Neuroscienze, C.so M. D'Azeglio 52, 10126, Torino, Italy. E-mail: maurizio.giustetto{at}unito.it.
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Author contributions

  1. Author contributions: M.G., L.P.-M., T.P., and N.M. designed research; N.M., R.S., F.P., M.P., R.M., and O.P. performed research; N.M., R.S., F.P., M.P., R.M., and O.P. analyzed data; M.G., L.P.-M., T.P., and N.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by grants from AIRETT ONLUS (to M.G. and T.P.), Rettsyndrome.org n. 2814 (to M.G.), National Institutes of Health (grant numbers NS-065027, HD-074418 to L.P.-M.), and the Summer Program in Neurobiology (SPIN; to R.S.).

Funding

  • AIRETT ONLUS

  • Rettsyndrome.org

    2814
  • HHS | National Institutes of Health (NIH)

    NS-065027; HD-074418
  • Summer program in neurobiology

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 11, 2018).

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AbstractFullPdf
Sep 201858041133
Oct 201866421076
Nov 20181043521
Dec 2018513817
Total 20181399324247
Jan 2019205711
Feb 2019186719
Mar 201937015
Apr 201987612
May 2019106221
Jun 2019125913
Jul 2019113411
Aug 201955522
Oct 201974616
Nov 201994411
Dec 201944013
Total 2019107610164
Jan 202075118
Feb 202073237
Mar 202033019
May 202023124
Jun 20201289
Jul 202012611
Aug 202022911
Sep 202024719
Oct 202015511
Nov 202035015
Dec 202068833
Total 202035467207
Jan 20215509
Feb 202124912
Mar 202116610
Apr 202134318
May 202146416
Jun 202115611
Jul 202125720
Aug 202106017
Sep 202104617
Oct 202118829
Nov 202116527
Dec 202107921
Total 202120723207
Jan 202216618
Feb 202245923
Mar 202224516
Apr 202204619
May 202226632
Jun 202245126
Jul 202214718
Aug 202212727
Sep 202202827
Oct 202223330
Nov 202224123
Dec 202234710
Total 202222556269
Jan 202304913
Feb 20233428
Mar 202305012
Apr 202336326
May 202333416
Jun 20230435
Jul 202373927
Aug 202375236
Sep 202324412
Oct 202317821
Nov 202395013
Dec 202336722
Total 202338611211
Jan 202494912
Feb 20247459
Mar 202454815
Apr 2024106824
May 202427117
Jun 202467430
Jul 202455519
Aug 2024115015
Sep 202414619
Oct 20244619
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Total 202462673185
Jan 202557624
Feb 20252826
Mar 202587128
Apr 202556017
May 202507714
Jun 202574915
Total 202527415104
Total171043791594
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Loss of Mecp2 Causes Atypical Synaptic and Molecular Plasticity of Parvalbumin-Expressing Interneurons Reflecting Rett Syndrome–Like Sensorimotor Defects
Noemi Morello, Riccardo Schina, Federica Pilotto, Mary Phillips, Riccardo Melani, Ornella Plicato, Tommaso Pizzorusso, Lucas Pozzo-Miller, Maurizio Giustetto
eNeuro 11 September 2018, 5 (5) ENEURO.0086-18.2018; DOI: 10.1523/ENEURO.0086-18.2018

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Loss of Mecp2 Causes Atypical Synaptic and Molecular Plasticity of Parvalbumin-Expressing Interneurons Reflecting Rett Syndrome–Like Sensorimotor Defects
Noemi Morello, Riccardo Schina, Federica Pilotto, Mary Phillips, Riccardo Melani, Ornella Plicato, Tommaso Pizzorusso, Lucas Pozzo-Miller, Maurizio Giustetto
eNeuro 11 September 2018, 5 (5) ENEURO.0086-18.2018; DOI: 10.1523/ENEURO.0086-18.2018
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Keywords

  • cerebral cortex
  • neuroanatomy
  • parvalbumin-expressing interneurons
  • Rett Syndrome
  • Structural synaptic plasticity
  • X-linked intellectual disability

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