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Research ArticleNew Research, Cognition and Behavior

AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus-Dependent Memory

Juan de la Parra, María I. Cuartero, Alberto Pérez-Ruiz, Alicia García-Culebras, Ricardo Martín, José Sánchez-Prieto, Juan M. García-Segura, Ignacio Lizasoain and María A. Moro
eNeuro 30 July 2018, 5 (4) ENEURO.0370-17.2018; DOI: https://doi.org/10.1523/ENEURO.0370-17.2018
Juan de la Parra
1Unidad De Investigación Neurovascular, Dpto. Farmacología y Toxicología, Facultad De Medicina, and Instituto Universitario De Investigación En Neuroquímica (IUIN), Universidad Complutense De Madrid (UCM); Instituto De Investigación Hospital 12 De Octubre (i+12), Madrid, Spain
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María I. Cuartero
1Unidad De Investigación Neurovascular, Dpto. Farmacología y Toxicología, Facultad De Medicina, and Instituto Universitario De Investigación En Neuroquímica (IUIN), Universidad Complutense De Madrid (UCM); Instituto De Investigación Hospital 12 De Octubre (i+12), Madrid, Spain
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Alberto Pérez-Ruiz
1Unidad De Investigación Neurovascular, Dpto. Farmacología y Toxicología, Facultad De Medicina, and Instituto Universitario De Investigación En Neuroquímica (IUIN), Universidad Complutense De Madrid (UCM); Instituto De Investigación Hospital 12 De Octubre (i+12), Madrid, Spain
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Alicia García-Culebras
1Unidad De Investigación Neurovascular, Dpto. Farmacología y Toxicología, Facultad De Medicina, and Instituto Universitario De Investigación En Neuroquímica (IUIN), Universidad Complutense De Madrid (UCM); Instituto De Investigación Hospital 12 De Octubre (i+12), Madrid, Spain
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Ricardo Martín
2Departamento De Bioquímica y Biología Molecular, Facultad De Veterinaria and IUIN, UCM, Madrid, Spain
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José Sánchez-Prieto
2Departamento De Bioquímica y Biología Molecular, Facultad De Veterinaria and IUIN, UCM, Madrid, Spain
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Juan M. García-Segura
3Departamento De Bioquímica y Biología Molecular, Facultad De Ciencias Químicas, and IUIN, UCM, Madrid, Spain
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Ignacio Lizasoain
1Unidad De Investigación Neurovascular, Dpto. Farmacología y Toxicología, Facultad De Medicina, and Instituto Universitario De Investigación En Neuroquímica (IUIN), Universidad Complutense De Madrid (UCM); Instituto De Investigación Hospital 12 De Octubre (i+12), Madrid, Spain
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María A. Moro
1Unidad De Investigación Neurovascular, Dpto. Farmacología y Toxicología, Facultad De Medicina, and Instituto Universitario De Investigación En Neuroquímica (IUIN), Universidad Complutense De Madrid (UCM); Instituto De Investigación Hospital 12 De Octubre (i+12), Madrid, Spain
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0370-17.2018
PubMed 
30225360
Published By 
Society for Neuroscience
History 
  • Received October 30, 2017
  • Revision received July 5, 2018
  • Accepted July 9, 2018
  • Published online July 30, 2018.
Copyright & Usage 
Copyright © 2018 de la Parra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Juan de la Parra1,*,
  2. María I. Cuartero1,*,
  3. Alberto Pérez-Ruiz1,
  4. Alicia García-Culebras1,
  5. Ricardo Martín2,
  6. José Sánchez-Prieto2,
  7. Juan M. García-Segura3,
  8. Ignacio Lizasoain1 and
  9. María A. Moro1
  1. 1Unidad De Investigación Neurovascular, Dpto. Farmacología y Toxicología, Facultad De Medicina, and Instituto Universitario De Investigación En Neuroquímica (IUIN), Universidad Complutense De Madrid (UCM); Instituto De Investigación Hospital 12 De Octubre (i+12), Madrid, Spain
  2. 2Departamento De Bioquímica y Biología Molecular, Facultad De Veterinaria and IUIN, UCM, Madrid, Spain
  3. 3Departamento De Bioquímica y Biología Molecular, Facultad De Ciencias Químicas, and IUIN, UCM, Madrid, Spain
  1. Correspondence should be addressed to either of the following: María A. Moro, Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Avenida Complutense s/n, 28040 Madrid, Spain. E-mail: neurona{at}ucm.es; or María I. Cuartero, Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Avenida Complutense s/n, 28040 Madrid, Spain. E-mail: maribel_cd{at}hotmail.com.
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Author contributions

  1. Author Contributions: JdlP, MIC, and MAM designed research; JdlP, MIC, APR, AGC, and RM performed research; JdlP, MIC, RM, JSP, JMGS, IL, and MAM analyzed data; JdlP, MIC, and MAM wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by grants from Spanish Ministry of Economy and Competitiveness SAF2015-68632-R (MAM) and SAF2016-81716-REDC (MAM), from Instituto de Salud Carlos III, and from Regional Madrid Government B2017/BMD-3688 (IL) and cofinanced by Fondo Europeo de Desarrollo Regional (FEDER) «Una manera de hacer Europa» PI17/01601 (IL) and RD16/0019/0009 (IL).

  • ↵* J. de la Parra and M.I. Cuartero contributed equally to this work.

Funding

  • Spanish Ministry of Economy and Competitiveness

    SAF2015-68632-R; SAF2016-81716-REDC
  • Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional (FEDER)

    RETICS RD16/0019/0009
  • MINECO | Instituto de Salud Carlos III (ISCIII)

    PI17/01601
  • Consejería de Educación, Juventud y Deporte, Comunidad de Madrid (Ministry of Education, Youth and Sports, Government of Madrid)

    B2017/BMD-3688

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Jul 2018102016
Aug 20182293176
Sep 201814318350
Oct 2018657032
Nov 2018443417
Dec 201825387
Total 2018608356198
Jan 2019116116
Feb 2019188416
Mar 20191920825
Apr 2019723515
May 2019718119
Jun 2019625420
Jul 2019544024
Aug 20191890223
Oct 20191775918
Nov 2019853530
Dec 2019829433
Total 20191243953239
Jan 202054820
Feb 202064838
Mar 202034214
May 202042311
Jun 202023316
Jul 202003525
Aug 20204217
Sep 202046924
Oct 20205676
Nov 202026826
Dec 20203753
Total 202038529190
Jan 202107426
Feb 202125413
Mar 202145919
Apr 20212557
May 202145312
Jun 20210598
Jul 20213495
Aug 202125819
Sep 20213467
Oct 202126723
Nov 202116031
Dec 202105717
Total 202123691187
Jan 202205417
Feb 20225408
Mar 202225120
Apr 202203811
May 202226820
Jun 202205414
Jul 20220337
Aug 202203613
Sep 202213016
Oct 202213624
Nov 20220348
Dec 202203420
Total 202211508178
Jan 202313811
Feb 20230388
Mar 20231397
Total 2023211526
Total80661521018
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AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus-Dependent Memory
Juan de la Parra, María I. Cuartero, Alberto Pérez-Ruiz, Alicia García-Culebras, Ricardo Martín, José Sánchez-Prieto, Juan M. García-Segura, Ignacio Lizasoain, María A. Moro
eNeuro 30 July 2018, 5 (4) ENEURO.0370-17.2018; DOI: 10.1523/ENEURO.0370-17.2018

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AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus-Dependent Memory
Juan de la Parra, María I. Cuartero, Alberto Pérez-Ruiz, Alicia García-Culebras, Ricardo Martín, José Sánchez-Prieto, Juan M. García-Segura, Ignacio Lizasoain, María A. Moro
eNeuro 30 July 2018, 5 (4) ENEURO.0370-17.2018; DOI: 10.1523/ENEURO.0370-17.2018
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Keywords

  • Aryl Hydrocarbon Receptor
  • dendrite arborization
  • hippocampal memory
  • newborn granule cells

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