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Research ArticleNew Research, Disorders of the Nervous System

Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology

Kyota Fujita, Hidenori Homma, Kanoh Kondo, Masashi Ikuno, Hodaka Yamakado, Kazuhiko Tagawa, Shigeo Murayama, Ryosuke Takahashi and Hitoshi Okazawa
eNeuro 16 August 2018, 5 (4) ENEURO.0217-18.2018; DOI: https://doi.org/10.1523/ENEURO.0217-18.2018
Kyota Fujita
1Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
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Hidenori Homma
1Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
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Kanoh Kondo
1Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
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Masashi Ikuno
2Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan
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  • ORCID record for Masashi Ikuno
Hodaka Yamakado
2Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan
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Kazuhiko Tagawa
1Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
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Shigeo Murayama
3Department of Neuropathology, Brain Bank for Aging Research, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakae-Cho, Itabashi-ku, Tokyo 173-0015, Japan
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Ryosuke Takahashi
2Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan
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Hitoshi Okazawa
1Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
4Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0217-18.2018
PubMed 
30225354
Published By 
Society for Neuroscience
History 
  • Received May 31, 2018
  • Revision received July 17, 2018
  • Accepted July 31, 2018
  • Published online August 16, 2018.
Copyright & Usage 
Copyright © 2018 Fujita et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kyota Fujita1,
  2. Hidenori Homma1,
  3. Kanoh Kondo1,
  4. Masashi Ikuno2,
  5. Hodaka Yamakado2,
  6. Kazuhiko Tagawa1,
  7. Shigeo Murayama3,
  8. Ryosuke Takahashi2 and
  9. Hitoshi Okazawa1,4
  1. 1Department of Neuropathology, Medical Research Institute and Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
  2. 2Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan
  3. 3Department of Neuropathology, Brain Bank for Aging Research, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakae-Cho, Itabashi-ku, Tokyo 173-0015, Japan
  4. 4Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
  1. Correspondence should be addressed to Hitoshi Okazawa. Email: okazawa-tky{at}umin.ac.jp
View Full Text

Author contributions

  1. Author contributions: K.F., H.H., K.K., I.M., and K.T. performed experiments and wrote the paper; H.Y., S.M., and R.T. provided the samples and wrote the paper; HO designed research and wrote the paper.

View Abstract

Disclosures

  • We report no conflict of interest.

  • This work was supported by Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from the Japan Agency for Medical Research and Development (AMED; JP18dm0207013h0005); the Strategic Research Program for Brain Sciences (SRPBS; JP18dm0107057h0002); and a Grant-in-Aid for Scientific Research on Innovative Areas “Foundation of Synapse and Neurocircuit Pathology” (22110001, 22110002) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT; to HO).

Funding

  • Japan Agency for Medical Research and Development (AMED)

    JP18dm0207013h0005; JP18dm0107057h0002
  • Japan Society for the Promotion of Science (JSPS)

    22110001; 22110002

Other Version

  • previous version (August 16, 2018).
  • You are viewing the most recent version of this article.

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Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology
Kyota Fujita, Hidenori Homma, Kanoh Kondo, Masashi Ikuno, Hodaka Yamakado, Kazuhiko Tagawa, Shigeo Murayama, Ryosuke Takahashi, Hitoshi Okazawa
eNeuro 16 August 2018, 5 (4) ENEURO.0217-18.2018; DOI: 10.1523/ENEURO.0217-18.2018

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Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology
Kyota Fujita, Hidenori Homma, Kanoh Kondo, Masashi Ikuno, Hodaka Yamakado, Kazuhiko Tagawa, Shigeo Murayama, Ryosuke Takahashi, Hitoshi Okazawa
eNeuro 16 August 2018, 5 (4) ENEURO.0217-18.2018; DOI: 10.1523/ENEURO.0217-18.2018
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Keywords

  • biomarker
  • degeneration
  • MARCKS
  • neurite
  • phosphorylation

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