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Research ArticleNew Research, Neuronal Excitability

The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons

Rhalena A. Thomas, Julien Gibon, Carol X. Q. Chen, Sabrina Chierzi, Vincent G. Soubannier, Stephanie Baulac, Philippe Séguéla, Keith Murai and Philip A. Barker
eNeuro 27 August 2018, 5 (4) ENEURO.0185-18.2018; https://doi.org/10.1523/ENEURO.0185-18.2018
Rhalena A. Thomas
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
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Julien Gibon
2Department of Biology, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada
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  • ORCID record for Julien Gibon
Carol X. Q. Chen
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
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Sabrina Chierzi
3Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3H2R9, Canada
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Vincent G. Soubannier
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
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Stephanie Baulac
4Université Pierre-et-Marie-Curie Université Paris 06, Sorbonne Universités, Paris, 75005, France; Institut National de la Santé et de la Recherche Médicale, Unité 1127, Paris, 75006, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France; Institut du Cerveau et de la Moelle Épinière), Paris, 75006, France; Groupe Hospitalier Pitié-Salpêtrière, Paris, 75013, France
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Philippe Séguéla
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
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Keith Murai
3Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3H2R9, Canada
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Philip A. Barker
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
2Department of Biology, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0185-18.2018
PubMed 
30225353
Published By 
Society for Neuroscience
History 
  • Received May 10, 2018
  • Revision received July 31, 2018
  • Accepted August 14, 2018
  • Published online August 27, 2018.
Copyright & Usage 
Copyright © 2018 Thomas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Rhalena A. Thomas1,
  2. Julien Gibon2,
  3. Carol X. Q. Chen1,
  4. Sabrina Chierzi3,
  5. Vincent G. Soubannier1,
  6. Stephanie Baulac4,
  7. Philippe Séguéla1,
  8. Keith Murai3 and
  9. Philip A. Barker1,2
  1. 1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
  2. 2Department of Biology, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada
  3. 3Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3H2R9, Canada
  4. 4Université Pierre-et-Marie-Curie Université Paris 06, Sorbonne Universités, Paris, 75005, France; Institut National de la Santé et de la Recherche Médicale, Unité 1127, Paris, 75006, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France; Institut du Cerveau et de la Moelle Épinière), Paris, 75006, France; Groupe Hospitalier Pitié-Salpêtrière, Paris, 75013, France
  1. Correspondence should be addressed to Philip A. Barker, Department of Biology, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada, E-mail: philip.barker{at}ubc.ca.
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Author contributions

  1. Author contributions: R.A.T., P.S., K.M., and P.A.B. designed research; R.A.T., J.G., C.X.Q.C., and S.C. performed research; S.B. contributed unpublished reagents/analytic tools; R.A.T., J.G., S.C., V.G.S., and P.A.B. analyzed data; R.A.T., J.G., and P.A.B. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Canadian Institute of Health Research (CIHR) Grants 37850 (to P.A.B.) and 130239 (to P.S.); the program “Investissements d’avenir” Grant ANR-10-IAIHU-06 (to S.B.); Fonds de Recherche du Québec Santé (FRQS) and McGill studentships (R.A.T.); and FRQS (J.G.).

Funding

  • Fonds de Recherche du Québec - Santé (FRQS)

  • Gouvernement du Canada | CIHR | Institute of Neurosciences, Mental Health and Addiction (INMHA)

  • Agence Nationale de la Recherche (ANR)

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  • You are viewing the most recent version of this article.
  • previous version (August 27, 2018).

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Aug 2018178012
Sep 201861617573
Oct 201812413438
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Apr 20199697
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Jan 202084212
Feb 202033536
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Aug 202032011
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Total 202138696182
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Total 2025100823260
Jan 2026208415
Feb 2026139022
Mar 20261310747
Apr 202624220
Total 202648323104
Total146254611577
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The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons
Rhalena A. Thomas, Julien Gibon, Carol X. Q. Chen, Sabrina Chierzi, Vincent G. Soubannier, Stephanie Baulac, Philippe Séguéla, Keith Murai, Philip A. Barker
eNeuro 27 August 2018, 5 (4) ENEURO.0185-18.2018; DOI: 10.1523/ENEURO.0185-18.2018

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The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons
Rhalena A. Thomas, Julien Gibon, Carol X. Q. Chen, Sabrina Chierzi, Vincent G. Soubannier, Stephanie Baulac, Philippe Séguéla, Keith Murai, Philip A. Barker
eNeuro 27 August 2018, 5 (4) ENEURO.0185-18.2018; DOI: 10.1523/ENEURO.0185-18.2018
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Keywords

  • epilepsy
  • leucine-rich glioma-inactivated gene 1
  • RhoA
  • synaptic activity
  • synaptic plasticity
  • TROY

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