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Research ArticleNew Research, Disorders of the Nervous System

Functional Connectivity of Chronic Cocaine Use Reveals Progressive Neuroadaptations in Neocortical, Striatal, and Limbic Networks

Caitlin A. Orsini, Luis M. Colon-Perez, Sara C. Heshmati, Barry Setlow and Marcelo Febo
eNeuro 17 July 2018, 5 (4) ENEURO.0081-18.2018; https://doi.org/10.1523/ENEURO.0081-18.2018
Caitlin A. Orsini
1Department of Psychiatry, University of Florida, Gainesville, FL 32611
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Luis M. Colon-Perez
1Department of Psychiatry, University of Florida, Gainesville, FL 32611
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  • ORCID record for Luis M. Colon-Perez
Sara C. Heshmati
1Department of Psychiatry, University of Florida, Gainesville, FL 32611
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Barry Setlow
1Department of Psychiatry, University of Florida, Gainesville, FL 32611
2Department of Neuroscience, University of Florida, Gainesville, FL 32611
3Department of Psychology, University of Florida, Gainesville, FL 32611
4Center for Addiction Research and Education (CARE), University of Florida, Gainesville, FL 32611
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Marcelo Febo
1Department of Psychiatry, University of Florida, Gainesville, FL 32611
2Department of Neuroscience, University of Florida, Gainesville, FL 32611
4Center for Addiction Research and Education (CARE), University of Florida, Gainesville, FL 32611
5Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) Facility, University of Florida, Gainesville, FL 32611
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0081-18.2018
PubMed 
30073194
Published By 
Society for Neuroscience
History 
  • Received February 22, 2018
  • Revision received June 25, 2018
  • Accepted July 10, 2018
  • Published online July 17, 2018.
Copyright & Usage 
Copyright © 2018 Orsini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Caitlin A. Orsini1,
  2. Luis M. Colon-Perez1,
  3. Sara C. Heshmati1,
  4. Barry Setlow1,2,3,4 and
  5. Marcelo Febo1,2,4,5
  1. 1Department of Psychiatry, University of Florida, Gainesville, FL 32611
  2. 2Department of Neuroscience, University of Florida, Gainesville, FL 32611
  3. 3Department of Psychology, University of Florida, Gainesville, FL 32611
  4. 4Center for Addiction Research and Education (CARE), University of Florida, Gainesville, FL 32611
  5. 5Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) Facility, University of Florida, Gainesville, FL 32611
  1. Correspondence should be addressed to Dr. Marcelo Febo, Department of Psychiatry, University of Florida, P.O. Box 100256, Gainesville, FL 32610. E-mail: febo{at}ufl.edu
View Full Text

Author contributions

  1. Author contributions: C.A.O., B.S., and M.F. designed research; C.A.O., L.M.C.-P., S.C.H., and M.F. performed research; C.A.O., L.M.C.-P., and M.F. analyzed data; C.A.O., L.M.C.-P., B.S., and M.F. wrote the paper.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported in part by National Institutes of Health Grants DA-038009 (M.F.), DA-024671 (B.S.), and DA-036534 (B.S.); a McKnight Brain Institute Postdoctoral Fellowship (L.M.C.-P.); a Thomas H. Maren Postdoctoral Fellowship (C.A.O.); and the National High Magnetic Field Laboratory Advanced Magnetic Resonance Imaging & Spectroscopy (AMRIS) Facility (National Science Foundation Cooperative Agreement No. DMR-1157490 and the State of Florida). The contents are solely the responsibility of the authors and do not necessarily represent the official views of the funding agencies.

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    DA038009; DA024671
  • Thomas H. Maren Foundation

  • McKnight Brain Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (July 17, 2018).

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Jul 2018802149114
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Oct 201848307127
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Feb 202034626
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Total 202032519265
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Apr 202127222
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Apr 20255599
May 202578420
Jun 2025179529
Jul 20251512627
Aug 202597924
Sep 2025721930
Oct 20251411037
Nov 20251277
Total 2025951025230
Total194760992017
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Functional Connectivity of Chronic Cocaine Use Reveals Progressive Neuroadaptations in Neocortical, Striatal, and Limbic Networks
Caitlin A. Orsini, Luis M. Colon-Perez, Sara C. Heshmati, Barry Setlow, Marcelo Febo
eNeuro 17 July 2018, 5 (4) ENEURO.0081-18.2018; DOI: 10.1523/ENEURO.0081-18.2018

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Functional Connectivity of Chronic Cocaine Use Reveals Progressive Neuroadaptations in Neocortical, Striatal, and Limbic Networks
Caitlin A. Orsini, Luis M. Colon-Perez, Sara C. Heshmati, Barry Setlow, Marcelo Febo
eNeuro 17 July 2018, 5 (4) ENEURO.0081-18.2018; DOI: 10.1523/ENEURO.0081-18.2018
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Keywords

  • cocaine
  • functional connectivity
  • network analysis
  • rat
  • resting-state fMRI
  • self-administration

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