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Research ArticleNew Research, Development

BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice

Zena K. Chatila, Eunhee Kim, Clara Berlé, Enjana Bylykbashi, Alexander Rompala, Mary K. Oram, Drew Gupta, Sang Su Kwak, Young Hye Kim, Doo Yeon Kim, Se Hoon Choi and Rudolph E. Tanzi
eNeuro 30 July 2018, 5 (4) ENEURO.0067-18.2018; DOI: https://doi.org/10.1523/ENEURO.0067-18.2018
Zena K. Chatila
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Eunhee Kim
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Clara Berlé
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Enjana Bylykbashi
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Alexander Rompala
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Mary K. Oram
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Drew Gupta
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Sang Su Kwak
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Young Hye Kim
2Biomedical Omics Group, Korea Basic Science Institute, Cheongju-si, Chungbuk 363-883, Republic of Korea
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Doo Yeon Kim
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Se Hoon Choi
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Rudolph E. Tanzi
1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0067-18.2018
PubMed 
30079376
Published By 
Society for Neuroscience
History 
  • Received February 7, 2018
  • Revision received June 5, 2018
  • Accepted June 25, 2018
  • Published online July 30, 2018.
Copyright & Usage 
Copyright © 2018 Chatila et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Zena K. Chatila1,*,
  2. Eunhee Kim1,*,
  3. Clara Berlé1,*,
  4. Enjana Bylykbashi1,
  5. Alexander Rompala1,
  6. Mary K. Oram1,
  7. Drew Gupta1,
  8. Sang Su Kwak1,
  9. Young Hye Kim2,
  10. Doo Yeon Kim1,
  11. Se Hoon Choi1 and
  12. Rudolph E. Tanzi1
  1. 1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129,
  2. 2Biomedical Omics Group, Korea Basic Science Institute, Cheongju-si, Chungbuk 363-883, Republic of Korea
  1. Correspondence should be addressed to either of the following: Rudolph E. Tanzi, Genetics and Aging Research Unit, Massachusetts General Hospital, 114 16th St, Charlestown, MA 02129. E-mail: tanzi{at}helix.mgh.harvard.edu; or Se Hoon Choi, Massachusetts General Hospital, 114 16th St, Charlestown, MA 02129. E-mail: Choi.SeHoon{at}mgh.harvard.edu.
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Author contributions

  1. Author contributions: SHC and RET designed research; RET supervised research; all the authors performed research; ZKC, EK, CB, SHC, and RET wrote the paper.

  2. ↵* Z.K.C., E.K., and C.B. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • Funding sources: Cure Alzheimer’s Fund. Dr. Young Hye Kim was supported by the Ministry of Science and ICT of Korea (NRF-2016R1A2B4015694).

Funding

  • Cure Alzheimer's Fund (CAF)

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  • You are viewing the most recent version of this article.
  • previous version (July 30, 2018).

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AbstractFullPdf
Jul 2018180027
Aug 2018980356366
Sep 201813911838
Oct 201810727984
Nov 2018658640
Dec 2018416226
Total 20181512901581
Jan 2019186426
Feb 20191713025
Mar 20192324536
Apr 2019824421
May 2019318723
Jun 2019514123
Jul 20191127021
Aug 2019752931
Oct 2019835418
Nov 20191326618
Dec 2019917723
Total 20191222607265
Jan 202055516
Feb 202053220
Mar 202023812
May 202054110
Jun 202034425
Jul 202032414
Aug 202053818
Sep 202064516
Oct 202046812
Nov 202046214
Dec 20206887
Total 202048535164
Jan 202138910
Feb 20212445
Mar 202137012
Apr 202136216
May 202168020
Jun 20210539
Jul 20211516
Aug 202157816
Sep 202125911
Oct 202157623
Nov 202135324
Dec 202126221
Total 202135777173
Jan 20220569
Feb 20225416
Mar 20222459
Apr 20225456
May 202227026
Jun 20221526
Jul 202204817
Aug 202243213
Sep 202204819
Oct 202215818
Nov 202223914
Dec 202223210
Total 202224566153
Jan 202314618
Feb 20231647
Mar 20231386
Apr 202304810
May 20232309
Jun 202305310
Jul 202314822
Aug 202324428
Sep 202324313
Total 202310414123
Total175158001459
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BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice
Zena K. Chatila, Eunhee Kim, Clara Berlé, Enjana Bylykbashi, Alexander Rompala, Mary K. Oram, Drew Gupta, Sang Su Kwak, Young Hye Kim, Doo Yeon Kim, Se Hoon Choi, Rudolph E. Tanzi
eNeuro 30 July 2018, 5 (4) ENEURO.0067-18.2018; DOI: 10.1523/ENEURO.0067-18.2018

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BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice
Zena K. Chatila, Eunhee Kim, Clara Berlé, Enjana Bylykbashi, Alexander Rompala, Mary K. Oram, Drew Gupta, Sang Su Kwak, Young Hye Kim, Doo Yeon Kim, Se Hoon Choi, Rudolph E. Tanzi
eNeuro 30 July 2018, 5 (4) ENEURO.0067-18.2018; DOI: 10.1523/ENEURO.0067-18.2018
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Keywords

  • adult neurogenesis
  • Alzheimer’s disease
  • BACE1
  • hippocampus

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