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Research ArticleNew Research, Sensory and Motor Systems

A Brain without Brakes: Reduced Inhibition Is Associated with Enhanced but Dysregulated Plasticity in the Aged Rat Auditory Cortex

J. Miguel Cisneros-Franco, Lydia Ouellet, Brishna Kamal and Etienne de Villers-Sidani
eNeuro 21 August 2018, 5 (4) ENEURO.0051-18.2018; DOI: https://doi.org/10.1523/ENEURO.0051-18.2018
J. Miguel Cisneros-Franco
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal QC H3A 2B4, Canada
2Centre for Research on Brain, Language, and Music, Montreal QC H3G 2A8, Canada
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Lydia Ouellet
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal QC H3A 2B4, Canada
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Brishna Kamal
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal QC H3A 2B4, Canada
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Etienne de Villers-Sidani
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal QC H3A 2B4, Canada
2Centre for Research on Brain, Language, and Music, Montreal QC H3G 2A8, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0051-18.2018
PubMed 
30225357
Published By 
Society for Neuroscience
History 
  • Received February 1, 2018
  • Revision received June 20, 2018
  • Accepted June 29, 2018
  • Published online August 21, 2018.
Copyright & Usage 
Copyright © 2018 Cisneros-Franco et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. J. Miguel Cisneros-Franco1,2,
  2. Lydia Ouellet1,
  3. Brishna Kamal1 and
  4. Etienne de Villers-Sidani1,2
  1. 1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal QC H3A 2B4, Canada
  2. 2Centre for Research on Brain, Language, and Music, Montreal QC H3G 2A8, Canada
  1. Correspondence should be addressed to J. Miguel Cisneros-Franco, 3801 University Rm 753, Montreal, QC, H3A2B4, Canada. E-mail: mike.cisneros-franco{at}mail.mcgill.ca.
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Author contributions

  1. Author Contributions: JMC and EdV designed research; JMC, LO, and BK performed research; JMC and EdV analyzed data; JMC and EdV wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR) grant MOP-133426 to EdV, and CIHR Vanier Canada Graduate Scholarship and CONACYT fellowship to JMC.

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

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  • You are viewing the most recent version of this article.
  • previous version (August 21, 2018).

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Aug 2018216032
Sep 2018791499215
Oct 201851425677
Nov 2018704628
Dec 20183340914
Total 201816241210366
Jan 2019185917
Feb 2019119813
Mar 20191617320
Apr 20191119417
May 20191116812
Jun 2019822412
Jul 20191144315
Aug 2019878617
Oct 2019470812
Nov 2019647116
Dec 2019631613
Total 20191103640164
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Mar 20203359
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Aug 20201308
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Oct 202031176
Nov 202038512
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Total 202043724134
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Feb 20213735
Mar 202147914
Apr 20212668
May 202161019
Jun 20212679
Jul 202146915
Aug 202136513
Sep 202138016
Oct 2021113632
Nov 202127123
Dec 20210785
Total 202130958163
Jan 202228213
Feb 20225468
Mar 2022112626
Apr 202207913
May 202217218
Jun 20222626
Jul 202225911
Aug 202227212
Sep 202206519
Oct 202237213
Nov 202236317
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Total 202224859180
Jan 202325921
Feb 202326814
Mar 202304713
Total 2023417448
Total183575651055
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eneuro: 5 (4)
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July/August 2018
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A Brain without Brakes: Reduced Inhibition Is Associated with Enhanced but Dysregulated Plasticity in the Aged Rat Auditory Cortex
J. Miguel Cisneros-Franco, Lydia Ouellet, Brishna Kamal, Etienne de Villers-Sidani
eNeuro 21 August 2018, 5 (4) ENEURO.0051-18.2018; DOI: 10.1523/ENEURO.0051-18.2018

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A Brain without Brakes: Reduced Inhibition Is Associated with Enhanced but Dysregulated Plasticity in the Aged Rat Auditory Cortex
J. Miguel Cisneros-Franco, Lydia Ouellet, Brishna Kamal, Etienne de Villers-Sidani
eNeuro 21 August 2018, 5 (4) ENEURO.0051-18.2018; DOI: 10.1523/ENEURO.0051-18.2018
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Keywords

  • aging
  • auditory cortex
  • cortical plasticity
  • GABA
  • inhibition
  • training

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