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Research ArticleNew Research, Disorders of the Nervous System

Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium

Naoto Tanaka, Giuseppe P. Cortese, Ruth M. Barrientos, Steven F. Maier and Susan L. Patterson
eNeuro 28 May 2018, 5 (3) ENEURO.0009-18.2018; https://doi.org/10.1523/ENEURO.0009-18.2018
Naoto Tanaka
1Department of Biology, Temple University, Philadelphia, PA 19122
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Giuseppe P. Cortese
2Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032
3Division of Molecular Therapeutics, New York Psychiatric Institute, New York, NY 10032
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Ruth M. Barrientos
4Department of Psychology & Neuroscience, University of Colorado, Boulder, CO 80309
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Steven F. Maier
4Department of Psychology & Neuroscience, University of Colorado, Boulder, CO 80309
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Susan L. Patterson
1Department of Biology, Temple University, Philadelphia, PA 19122
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0009-18.2018
PubMed 
29911174
Published By 
Society for Neuroscience
History 
  • Received January 4, 2018
  • Revision received May 2, 2018
  • Accepted May 4, 2018
  • Published online May 28, 2018.
Copyright & Usage 
Copyright © 2018 Tanaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Naoto Tanaka1,
  2. Giuseppe P. Cortese2,3,
  3. Ruth M. Barrientos4,
  4. Steven F. Maier4 and
  5. Susan L. Patterson1
  1. 1Department of Biology, Temple University, Philadelphia, PA 19122
  2. 2Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032
  3. 3Division of Molecular Therapeutics, New York Psychiatric Institute, New York, NY 10032
  4. 4Department of Psychology & Neuroscience, University of Colorado, Boulder, CO 80309
  1. Correspondence should be addressed to Susan L. Patterson, Department of Biology, Temple University,1900 North 12th Street, Philadelphia, PA 19122. E-mail: susan.patterson{at}temple.edu.
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Author contributions

  1. Author contributions: N.T., G.P.C., R.M.B., and S.F.M. performed research; N.T. and G.P.C. analyzed data; N.T., S.F.M., and S.L.P. wrote the paper; S.L.P. designed research.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institute on Aging Grants 5R01AG041944 (to S.L.P.) and 1R01AG02827 (to S.F.M. and R.M.B.).

Funding

  • HHS | NIH | National institute on aging (NIA)

    5R01AG041944
  • National institute on aging

    1R01AG02827

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AbstractFullPdf
May 2018424093
Jun 20181236389193
Jul 2018975442
Aug 2018586160
Sep 2018483741
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Total 20181952687527
Jan 2019155327
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Mar 2019128724
Apr 201987933
May 201974017
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Jan 202044122
Feb 202053528
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Oct 202025719
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Total 202027442223
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Apr 202135114
May 20213476
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Sep 2025511012
Oct 20259599
Nov 2025158322
Dec 2025129124
Total 202583796197
Jan 202610467
Total 202610467
Total233249921795
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Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium
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Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium
Naoto Tanaka, Giuseppe P. Cortese, Ruth M. Barrientos, Steven F. Maier, Susan L. Patterson
eNeuro 28 May 2018, 5 (3) ENEURO.0009-18.2018; DOI: 10.1523/ENEURO.0009-18.2018

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Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium
Naoto Tanaka, Giuseppe P. Cortese, Ruth M. Barrientos, Steven F. Maier, Susan L. Patterson
eNeuro 28 May 2018, 5 (3) ENEURO.0009-18.2018; DOI: 10.1523/ENEURO.0009-18.2018
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Keywords

  • BDNF
  • Delirium
  • hippocampus
  • Interleukin-1beta
  • LTP
  • microglia

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