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Research ArticleNew Research, Disorders of the Nervous System

PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

Kathrine Louise Jensen, Gunnar Sørensen, Ditte Dencker, William Anthony Owens, Troels Rahbek-Clemmensen, Michael Brett Lever, Annika H. Runegaard, Nikolaj Riis Christensen, Pia Weikop, Gitta Wörtwein, Anders Fink-Jensen, Kenneth L. Madsen, Lynette Daws, Ulrik Gether and Mattias Rickhag
eNeuro 14 May 2018, 5 (3) ENEURO.0422-17.2018; https://doi.org/10.1523/ENEURO.0422-17.2018
Kathrine Louise Jensen
1Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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  • ORCID record for Kathrine Louise Jensen
Gunnar Sørensen
1Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
2Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Ditte Dencker
2Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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William Anthony Owens
3Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, TX 78229
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Troels Rahbek-Clemmensen
1Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Michael Brett Lever
1Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Annika H. Runegaard
1Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Nikolaj Riis Christensen
1Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Pia Weikop
2Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Gitta Wörtwein
2Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Anders Fink-Jensen
2Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Kenneth L. Madsen
1Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Lynette Daws
3Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, TX 78229
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Ulrik Gether
1Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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Mattias Rickhag
1Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
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PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis
Kathrine Louise Jensen, Gunnar Sørensen, Ditte Dencker, William Anthony Owens, Troels Rahbek-Clemmensen, Michael Brett Lever, Annika H. Runegaard, Nikolaj Riis Christensen, Pia Weikop, Gitta Wörtwein, Anders Fink-Jensen, Kenneth L. Madsen, Lynette Daws, Ulrik Gether, Mattias Rickhag
eNeuro 14 May 2018, 5 (3) ENEURO.0422-17.2018; DOI: 10.1523/ENEURO.0422-17.2018

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PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis
Kathrine Louise Jensen, Gunnar Sørensen, Ditte Dencker, William Anthony Owens, Troels Rahbek-Clemmensen, Michael Brett Lever, Annika H. Runegaard, Nikolaj Riis Christensen, Pia Weikop, Gitta Wörtwein, Anders Fink-Jensen, Kenneth L. Madsen, Lynette Daws, Ulrik Gether, Mattias Rickhag
eNeuro 14 May 2018, 5 (3) ENEURO.0422-17.2018; DOI: 10.1523/ENEURO.0422-17.2018
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Keywords

  • cocaine
  • Dopamine Homeostasis
  • drug addiction
  • Protein Interacting with C-Kinase 1
  • striatum
  • tyrosine hydroxylase

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