Article Figures & Data
Figures
- Figure 1.
The two stimulation sites for cTBS consisted of the right ventral premotor cortex and right inferior parietal lobule. Both target points were localized using individual brain anatomy (for details, see TMS stimulation and site localization), and cTBS stimulation was guided by neuronavigation. Individual target points are displayed in Talairach space for rPMv (green) and rIPL (yellow). The red spheres indicate the average stimulation coordinates.
- Figure 2.
Clusters showing a significant main effect of session displayed on an averaged anatomy of all participants in Talairach space (p = 0.05, cluster size corrected). For details about cluster size and statistical significance, see Table 3.
- Figure 3.
Clusters showing a significant emotion × session interaction displayed on an averaged anatomy of all participants in Talairach space (p = 0.05, cluster size corrected). For details about cluster size and statistical significance, see Table 4.
- Figure 4.
Results from ROI analysis based on individual stimulation sites (rPMv and rIPL). β values in rPMv showed a significant emotion × session interaction effect, whereas in rIPL no significant effects were found.
- Figure 5.
Results from ROI analysis based on individual anatomy (amygdala) or functional activity (EBA and pSTS). β values in rAMG, bilateral EBA, and rpSTS reflected a main effect of emotion, whereas in lAMG an interaction effect was also present. In lAMG, there was no effect of emotion at baseline, but this effect was evident for both cTBS sessions.
Tables
Stimulation site x y z Inferior parietal lobule 41 ± 7 −62 ± 9 43 ± 5 Ventral premotor cortex 50 ± 6 11 ± 4 29 ± 5 Values are reported as the mean ± SD.
Anatomical description Hemisphere Cluster size x y z F value p value Widespread occipital/fusiform gyrus R 16,826 43 −67 0 85.09 0.000000 Anterior inferior temporal gyrus R 363 36 −5 −36 45.78 0.000005 Amygdala R 347 25 −1 −12 56.63 0.000001 Pulvinar R 354 17 −27 2 45.70 0.000005 Superior parieto-occipital cortex R/L 2864 1 −59 0 54.17 0.000002 Widespread occipital/fusiform gyrus L 22,222 −15 −89 −2 75.61 0.000000 Amygdala L 697 −35 −1 −12 45.41 0.000005 Cluster size is reported in number of voxels (voxel size = 1 mm³). Reported values (coordinates, F value, and p value) reflect cluster peak. L, Left; R, right.
Anatomical description Hemisphere Cluster size x y z F value p value Ventromedial prefrontal cortex R 112 11 49 4 15.37 0.000021 Posterior cingulate cortex L 197 −3 −41 28 14.87 0.000027 Precuneus L 108 −15 −59 32 11.97 0.000131 Superior parietal lobe L 107 −29 −53 50 15.47 0.000020 Ventral premotor cortex L 255 −47 1 28 11.73 0.000151 Cluster size is reported in number of voxels (voxel size = 1 mm³). reported values (coordinates, F value, and p value) reflect cluster peak. L, Left; R, right.
- Table 4.
Clusters found for the emotion × session interaction (α = 0.05, cluster size corrected)
Anatomical description Hemisphere Cluster size x y z F value p value Lingual gyrus R 287 17 −77 −8 13.76 0.000049 Superior parietal lobe R 1077 15 −73 44 17.98 0.000006 SMA R/L 505 −1 3 54 12.77 0.000084 Superior parietal lobe L 802 −13 −69 48 15.47 0.000020 Superior parieto-occipital cortex L 340 −17 −65 26 14.99 0.000025 Cerebellum L 164 −19 −71 −22 12.12 0.000120 Precuneus L 354 −27 −59 46 14.52 0.000032 Ventral premotor cortex L 113 −49 9 26 13.20 0.000066 Cluster size is reported in number of voxels (voxel size = 1 mm³). Reported values (coordinates, F value, and p value) reflect cluster peak. L, Left; R, right.
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