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Research ArticleNew Research, Cognition and Behavior

Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats

Jenni Kononoff, Marsida Kallupi, Adam Kimbrough, Dana Conlisk, Giordano de Guglielmo and Olivier George
eNeuro 25 June 2018, 5 (3) ENEURO.0153-18.2018; https://doi.org/10.1523/ENEURO.0153-18.2018
Jenni Kononoff
1Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
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  • ORCID record for Jenni Kononoff
Marsida Kallupi
1Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
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Adam Kimbrough
1Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
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Dana Conlisk
1Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
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Giordano de Guglielmo
1Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
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Olivier George
1Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0153-18.2018
PubMed 
29971251
Published By 
Society for Neuroscience
History 
  • Received April 16, 2018
  • Revision received May 23, 2018
  • Accepted June 7, 2018
  • Published online June 25, 2018.
Copyright & Usage 
Copyright © 2018 Kononoff et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jenni Kononoff1,
  2. Marsida Kallupi1,
  3. Adam Kimbrough1,
  4. Dana Conlisk1,
  5. Giordano de Guglielmo1 and
  6. Olivier George1
  1. 1Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
  1. Correspondence should be addressed to Dr. Olivier George, Department of Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, E-mail: ogeorge{at}scripps.edu.
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Author contributions

  1. Author contributions: J.K., M.K., G.d.G., and O.G. designed research; J.K., A.K., and D.C. performed research; J.K., M.K., and G.d.G. analyzed data; J.K. and O.G. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants AA007456, AA006420, AA022977, AA026081, and AA020608; the Pearson Center for Alcoholism and Addiction Research; the Sigrid Juselius Foundation (J.K.); and the Emil Aaltonen Foundation (J.K.).

Funding

  • the Pearson Center for Alcoholism and Addiction Research

  • the Sigrid Juselius Foundation

  • the Emil Aaltonen Foundation

  • HHS | National Institutes of Health (NIH)

    AA007456; AA006420; AA022977; AA020608; AA02608

Other Version

  • You are viewing the most recent version of this article.
  • previous version (June 25, 2018).

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Jun 20188830191
Jul 20181236698249
Aug 201830730397
Sep 20181929619
Oct 201821116260
Nov 201826126857
Dec 201819639616
Total 201832861923689
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Feb 20192033921
Mar 20191736325
Apr 20191927623
May 20191625213
Jun 20191319018
Jul 20191424723
Aug 20191256731
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Total 20192093503227
Jan 202085814
Feb 202075527
Mar 202063810
May 202077210
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Jul 202043312
Aug 202024015
Sep 202078721
Oct 202089418
Nov 202069025
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Total 202065753187
Jan 202158116
Feb 202147910
Mar 202177714
Apr 202159313
May 202145714
Jun 202128812
Jul 202149019
Aug 20216797
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Total 202162946197
Jan 202246022
Feb 202286312
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Apr 202214911
May 202246216
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Jul 20222457
Aug 202224111
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Total 202242687164
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May 202334910
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Jul 202375428
Aug 2023176636
Sep 2023148319
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Total 2023921129205
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Total 2024107853211
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Feb 202599420
Mar 2025108130
Apr 202507113
May 202517915
Jun 202569819
Jul 20251111440
Aug 2025127131
Sep 20251119223
Oct 202569713
Nov 20252913321
Dec 20251511339
Total 20251201212289
Jan 20261917523
Feb 20261935213
Mar 20261210447
Apr 202684826
Total 202658679109
Total4041116852278
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Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats
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Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats
Jenni Kononoff, Marsida Kallupi, Adam Kimbrough, Dana Conlisk, Giordano de Guglielmo, Olivier George
eNeuro 25 June 2018, 5 (3) ENEURO.0153-18.2018; DOI: 10.1523/ENEURO.0153-18.2018

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Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats
Jenni Kononoff, Marsida Kallupi, Adam Kimbrough, Dana Conlisk, Giordano de Guglielmo, Olivier George
eNeuro 25 June 2018, 5 (3) ENEURO.0153-18.2018; DOI: 10.1523/ENEURO.0153-18.2018
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Keywords

  • alcohol use disorder
  • compulsivity
  • habenula
  • Orphan receptor
  • pain
  • withdrawal

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