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Research ArticleConfirmation, Disorders of the Nervous System

TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling

Erin Frey, Scott Karney-Grobe, Trevor Krolak, Jeff Milbrandt and Aaron DiAntonio
eNeuro 21 May 2018, 5 (3) ENEURO.0095-18.2018; https://doi.org/10.1523/ENEURO.0095-18.2018
Erin Frey
1Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA
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Scott Karney-Grobe
1Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA
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Trevor Krolak
1Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA
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Jeff Milbrandt
2Department of Genetics, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA
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Aaron DiAntonio
1Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0095-18.2018
PubMed 
29854941
Published By 
Society for Neuroscience
History 
  • Received March 10, 2018
  • Revision received May 15, 2018
  • Accepted May 15, 2018
  • Published online May 21, 2018.
Copyright & Usage 
Copyright © 2018 Frey et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Erin Frey1,
  2. Scott Karney-Grobe1,
  3. Trevor Krolak1,
  4. Jeff Milbrandt2 and
  5. Aaron DiAntonio1
  1. 1Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA
  2. 2Department of Genetics, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA
  1. Correspondence should be addressed to Aaron DiAntonio, Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 S. Euclid, St. Louis, MO 63110. E-mail: diantonio{at}wustl.edu.
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Author contributions

  1. Author contributions: E.F., S.K.G., A.D., and J.M. designed experiments. E.F, S.K.G., and T.K. performed experiments. E.F. and S.K.G. analyzed data. A.D. and E.F wrote the manuscript.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by funding from the National Institutes of Health Grants NIH NS087562 to A.D. and J.M. and NIH NS065053 to A.D., National Institutes of Health Grant NIH F32NS093962 to E.F., and the Philip and Sima Needleman Student Fellowship in Regenerative Medicine to S.K.G.

Funding

  • Philip and Sima Needleman Student Fellowship in Regenerative Medicine

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    F32NS093962
  • HHS | National Institutes of Health (NIH)

    NS087562; NS065053

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 21, 2018).

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AbstractFullPdf
May 201846930128
Jun 2018760351247
Jul 2018774820
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Sep 2018304117
Oct 2018397431
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Total 20181496972712
Jan 2019207021
Feb 20191612825
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Aug 2019771425
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Jan 202074214
Feb 202074436
Mar 202058128
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Jun 202003838
Jul 202022913
Aug 202054751
Sep 202089246
Oct 2020312331
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Total 202051704362
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Feb 202115614
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Apr 202145311
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Total 202126742259
Jan 202225921
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Apr 202227116
May 202215735
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Jul 202205515
Aug 202233613
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Total 202220803231
Jan 202327719
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Apr 202315412
May 20233286
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Jul 202318634
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Total 202348820255
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Jan 2025107787
Feb 202588224
Mar 202537913
Apr 202524626
May 202517826
Jun 2025129036
Jul 202599918
Aug 2025128335
Sep 20254522230
Oct 20251311732
Nov 20252415623
Dec 20251612238
Total 20251551251388
Jan 20269538
Total 20269538
Total200694162705
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eneuro: 5 (3)
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May/June 2018
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TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling
Erin Frey, Scott Karney-Grobe, Trevor Krolak, Jeff Milbrandt, Aaron DiAntonio
eNeuro 21 May 2018, 5 (3) ENEURO.0095-18.2018; DOI: 10.1523/ENEURO.0095-18.2018

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TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling
Erin Frey, Scott Karney-Grobe, Trevor Krolak, Jeff Milbrandt, Aaron DiAntonio
eNeuro 21 May 2018, 5 (3) ENEURO.0095-18.2018; DOI: 10.1523/ENEURO.0095-18.2018
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    • Significance Statement
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Keywords

  • axon regeneration
  • capsaicin
  • Neurite outgrowth
  • PKA
  • Preconditioning
  • TRPV1

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