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Research ArticleNew Research, Disorders of the Nervous System

Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome

Ryan T. Ash, Paul G. Fahey, Jiyoung Park, Huda Y. Zoghbi and Stelios M. Smirnakis
eNeuro 18 June 2018, 5 (3) ENEURO.0056-17.2018; DOI: https://doi.org/10.1523/ENEURO.0056-17.2018
Ryan T. Ash
1Department of Neurology, Brigham and Women’s Hospital and Jamaica Plain Veterans Administration Hospital, Harvard Medical School, Boston, MA 02115
2Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030
3Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
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Paul G. Fahey
2Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030
3Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
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  • ORCID record for Paul G. Fahey
Jiyoung Park
1Department of Neurology, Brigham and Women’s Hospital and Jamaica Plain Veterans Administration Hospital, Harvard Medical School, Boston, MA 02115
3Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
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Huda Y. Zoghbi
3Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
4Department of Pediatrics, Texas Children’s Hospital and Baylor College of Medicine, Houston, TX 77030
5Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030
6Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, TX 77030
7Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
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Stelios M. Smirnakis
1Department of Neurology, Brigham and Women’s Hospital and Jamaica Plain Veterans Administration Hospital, Harvard Medical School, Boston, MA 02115
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0056-17.2018
PubMed 
30105297
Published By 
Society for Neuroscience
History 
  • Received February 17, 2017
  • Revision received February 20, 2018
  • Accepted March 28, 2018
  • Published online June 18, 2018.
Copyright & Usage 
Copyright © 2018 Ash et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ryan T. Ash1,2,3,*,
  2. Paul G. Fahey2,3,*,
  3. Jiyoung Park1,3,
  4. Huda Y. Zoghbi3,4,5,6,7 and
  5. Stelios M. Smirnakis1
  1. 1Department of Neurology, Brigham and Women’s Hospital and Jamaica Plain Veterans Administration Hospital, Harvard Medical School, Boston, MA 02115
  2. 2Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030
  3. 3Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
  4. 4Department of Pediatrics, Texas Children’s Hospital and Baylor College of Medicine, Houston, TX 77030
  5. 5Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030
  6. 6Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, TX 77030
  7. 7Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
  1. Correspondence should be addressed to Stelios M. Smirnakis, Brigham and Women’s Hospital, Suite BB-328, 60 Francis Street, Boston MA 02115. E-mail: smsmirnakis{at}bwh.harvard.edu
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Author contributions

  1. Author contributions: R.T.A., H.Y.Z., and S.M.S. designed research; R.T.A. and J.P. performed research; R.T.A. contributed unpublished reagents/analytic tools; R.T.A. and P.G.F. analyzed data; R.T.A., J.P., and S.M.S. wrote the paper.

  2. ↵* R.T.A. and P.G.F. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • R.T.A. received support from the Autism Speaks Weatherstone Fellowship and the BCM Medical Scientist Training Program. P.G.F. received support from the BCM Medical Scientist Training Program, F30 F3-MH112312, and Baylor Research Advocates for Student Scientists (BRASS). This work was supported by grants from the Simons Foundation and March of Dimes to S.M.S., the Howard Hughes Medical Institute and National Institute of Neurological Disorders and Stroke Grant HD-053862 to H.Y.Z., and Grant P30-HD-024064 to the Baylor Intellectual and Developmental Disabilities Research Center Mouse Neurobehavioral Core.

Funding

  • Autism Speaks Weatherstone Fellowship

    7053
  • Simons Foundation

    240069
  • NINDS

    NINDS HD053862
  • Developmental Disabilities Research Core

    P30HD024064

Other Version

  • You are viewing the most recent version of this article.
  • previous version (June 18, 2018).

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AbstractFullPdf
Jun 2018184038
Jul 201899015
Aug 2018918668
Sep 2018484015
Oct 2018515844
Nov 2018293024
Dec 2018262112
Total 2018528235216
Jan 201914549
Feb 20191310410
Mar 20191221714
Apr 20191524219
May 20191014213
Jun 20191522526
Jul 20191437014
Aug 20191780730
Oct 2019764510
Nov 20191044719
Dec 2019526018
Total 20191323513182
Jan 202084016
Feb 202053527
Mar 202024411
May 202053927
Jun 202045812
Jul 20204244
Aug 202002910
Sep 202074321
Oct 202087724
Nov 202044111
Dec 202088315
Total 202055513178
Jan 202145016
Feb 202145915
Mar 202157417
Apr 202165818
May 202125613
Jun 202116018
Jul 202155423
Aug 202106426
Sep 202125314
Oct 202177250
Nov 202105938
Dec 202106318
Total 202136722266
Jan 202204912
Feb 202223413
Mar 202223616
Apr 20220428
May 202228012
Jun 202215113
Jul 202233517
Aug 202203513
Sep 202232214
Oct 202214114
Nov 202213017
Dec 202274518
Total 202222500167
Jan 20232223
Total 20232223
Total77555051012
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Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome
Ryan T. Ash, Paul G. Fahey, Jiyoung Park, Huda Y. Zoghbi, Stelios M. Smirnakis
eNeuro 18 June 2018, 5 (3) ENEURO.0056-17.2018; DOI: 10.1523/ENEURO.0056-17.2018

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Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome
Ryan T. Ash, Paul G. Fahey, Jiyoung Park, Huda Y. Zoghbi, Stelios M. Smirnakis
eNeuro 18 June 2018, 5 (3) ENEURO.0056-17.2018; DOI: 10.1523/ENEURO.0056-17.2018
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Keywords

  • autism
  • bouton
  • MECP2
  • Motor learning
  • plasticity
  • synaptic

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