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Research ArticleConfirmation, Disorders of the Nervous System

Behavioral Phenotyping of an Improved Mouse Model of Phelan–McDermid Syndrome with a Complete Deletion of the Shank3 Gene

Elodie Drapeau, Mohammed Riad, Yuji Kajiwara and Joseph D. Buxbaum
eNeuro 5 June 2018, 5 (3) ENEURO.0046-18.2018; DOI: https://doi.org/10.1523/ENEURO.0046-18.2018
Elodie Drapeau
1Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029
2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Mohammed Riad
1Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029
2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Yuji Kajiwara
1Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029
2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Joseph D. Buxbaum
1Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029
2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029
3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
4Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029
5Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
6Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0046-18.2018
PubMed 
30302388
Published By 
Society for Neuroscience
History 
  • Received January 24, 2018
  • Revision received May 7, 2018
  • Accepted May 28, 2018
  • Published online June 5, 2018.
Copyright & Usage 
Copyright © 2018 Drapeau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Elodie Drapeau1,2,
  2. Mohammed Riad1,2,
  3. Yuji Kajiwara1,2 and
  4. Joseph D. Buxbaum1,2,3,4,5,6
  1. 1Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029
  2. 2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029
  3. 3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
  4. 4Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029
  5. 5Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
  6. 6Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
  1. Correspondence should be addressed to Joseph D. Buxbaum, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029. E-mail: joseph.buxbaum{at}mssm.edu.
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Author contributions

  1. Author contributions: J.D.B. and E.D. designed research; E.D., M.R., and Y.K. performed research; E.D. analyzed data; E.D. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Beatrice and Samuel A. Seaver Foundation and by National Institutes of Health Grants R01MH093725 and R01MH101584.

Funding

  • HHS | National Institutes of Health (NIH)

    R01MH093725; R01MH101584
  • Beatrice and Samuel A. Seaver Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (June 05, 2018).

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AbstractFullPdf
Jun 2018314082
Jul 2018127069
Aug 2018174043
Sep 201865025
Oct 20188812357
Nov 2018444131
Dec 2018495439
Total 2018861218346
Jan 2019286427
Feb 2019138326
Mar 20191416135
Apr 20191515527
May 20191411531
Jun 2019410031
Jul 20191311948
Aug 201998637
Oct 20191114634
Nov 2019817736
Dec 2019310731
Total 20191321313363
Jan 2020811728
Feb 202029941
Mar 202058531
May 202019738
Jun 202065827
Jul 202029330
Aug 202017827
Sep 202057431
Oct 2020217634
Nov 202029124
Dec 2020212023
Total 2020361088334
Jan 2021613232
Feb 202148817
Mar 20211013041
Apr 202189635
May 2021411449
Jun 2021210551
Jul 202129249
Aug 2021710349
Sep 2021510043
Oct 2021311966
Nov 202129344
Dec 202129845
Total 2021551270521
Jan 2022311148
Feb 2022610647
Mar 2022313657
Apr 2022412347
May 2022312034
Jun 2022310931
Jul 202258936
Aug 202228127
Sep 202255930
Oct 202237636
Nov 202238333
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Total 2022461162461
Jan 202327135
Feb 2023111618
Mar 202318025
Total 2023426778
Total113453182103
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eneuro: 5 (3)
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May/June 2018
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Behavioral Phenotyping of an Improved Mouse Model of Phelan–McDermid Syndrome with a Complete Deletion of the Shank3 Gene
Elodie Drapeau, Mohammed Riad, Yuji Kajiwara, Joseph D. Buxbaum
eNeuro 5 June 2018, 5 (3) ENEURO.0046-18.2018; DOI: 10.1523/ENEURO.0046-18.2018

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Behavioral Phenotyping of an Improved Mouse Model of Phelan–McDermid Syndrome with a Complete Deletion of the Shank3 Gene
Elodie Drapeau, Mohammed Riad, Yuji Kajiwara, Joseph D. Buxbaum
eNeuro 5 June 2018, 5 (3) ENEURO.0046-18.2018; DOI: 10.1523/ENEURO.0046-18.2018
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Keywords

  • 22q13
  • autism spectrum disorder
  • behavior
  • mouse model
  • Phelan–McDermid syndrome
  • Shank3

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Confirmation

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Disorders of the Nervous System

  • Evaluating the Burstlet Theory of Inspiratory Rhythm and Pattern Generation
  • Sex and Individual Differences in Alcohol Intake Are Associated with Differences in Ketamine Self-Administration Behaviors and Nucleus Accumbens Dendritic Spine Density
  • Developmental Nicotine Exposure Alters Synaptic Input to Hypoglossal Motoneurons and Is Associated with Altered Function of Upper Airway Muscles
Show more Disorders of the Nervous System

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  • Disorders of the Nervous System

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