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Research ArticleNegative Results, Sensory and Motor Systems

Metabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons

Tayler D. Sheahan, Manouela V. Valtcheva, Lisa A. McIlvried, Melanie Y. Pullen, David A.A. Baranger and Robert W. Gereau IV
eNeuro 5 March 2018, 5 (2) ENEURO.0412-17.2018; https://doi.org/10.1523/ENEURO.0412-17.2018
Tayler D. Sheahan
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110
2Washington University Program in Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110
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  • ORCID record for Tayler D. Sheahan
Manouela V. Valtcheva
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110
2Washington University Program in Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110
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Lisa A. McIlvried
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110
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  • ORCID record for Lisa A. McIlvried
Melanie Y. Pullen
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110
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David A.A. Baranger
2Washington University Program in Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110
3BRAIN Laboratory, Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri 63130
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Robert W. Gereau IV
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0412-17.2018
PubMed 
29662945
Published By 
Society for Neuroscience
History 
  • Received November 29, 2017
  • Revision received February 6, 2018
  • Accepted February 7, 2018
  • Published online March 5, 2018.
Copyright & Usage 
Copyright © 2018 Sheahan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Tayler D. Sheahan1,2,
  2. Manouela V. Valtcheva1,2,
  3. Lisa A. McIlvried1,
  4. Melanie Y. Pullen1,
  5. David A.A. Baranger2,3 and
  6. Robert W. Gereau IV1
  1. 1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110
  2. 2Washington University Program in Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110
  3. 3BRAIN Laboratory, Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri 63130
  1. Correspondence should be addressed to Robert W. Gereau IV, PhD, Director | Washington University Pain Center, Dr. Seymour and Rose T. Brown Professor, Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8054, St. Louis, MO 63110, Telephone number: (314) 362-8312, Fax Number: (314) 362-8334, E-mail: gereaur{at}wustl.edu.
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Author contributions

  1. Author contributions: T.D.S. and R.W.G. IV designed research; T.D.S., M.V.V., L.A.M., and M.Y.P. performed research; T.D.S. and D.A.A.B. analyzed data; T.D.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • Conflict of Interest: Authors report no conflict of interest.

  • This work was supported by NINDS R01NS042595 to RWG, NINDS F31NS089130 to MVV, NIDA 2T32 DA007261-26 to LAM, and NSF DGE1745038 to DAAB.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS042595; F31NS089130
  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    2T32 DA007261-26
  • NSF | EHR | Division of Graduate Education (DGE)

    DGE1745038

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  • You are viewing the most recent version of this article.
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Mar 20187520147
Apr 20181849881
May 20181187844
Jun 2018466744
Jul 2018369638
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Total 201813081072495
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Apr 202516211
May 202557617
Jun 2025129024
Jul 202513615
Total 202528504128
Total168675731849
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Metabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons
Tayler D. Sheahan, Manouela V. Valtcheva, Lisa A. McIlvried, Melanie Y. Pullen, David A.A. Baranger, Robert W. Gereau IV
eNeuro 5 March 2018, 5 (2) ENEURO.0412-17.2018; DOI: 10.1523/ENEURO.0412-17.2018

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Metabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons
Tayler D. Sheahan, Manouela V. Valtcheva, Lisa A. McIlvried, Melanie Y. Pullen, David A.A. Baranger, Robert W. Gereau IV
eNeuro 5 March 2018, 5 (2) ENEURO.0412-17.2018; DOI: 10.1523/ENEURO.0412-17.2018
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Keywords

  • Dorsal root ganglia
  • glutamate
  • human neurons
  • Metabotropic
  • Nociceptors
  • pain

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