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Research ArticleNew Research, Sensory and Motor Systems

Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat

Dan Carlin, Judith P. Golden, Amit Mogha, Vijay K. Samineni, Kelly R. Monk, Robert W. Gereau IV and Valeria Cavalli
eNeuro 25 April 2018, 5 (2) ENEURO.0436-17.2018; https://doi.org/10.1523/ENEURO.0436-17.2018
Dan Carlin
1Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110
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Judith P. Golden
2Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
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Amit Mogha
3Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110
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Vijay K. Samineni
2Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
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Kelly R. Monk
3Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110
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Robert W. Gereau IV
2Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
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Valeria Cavalli
4Department of Neuroscience, Hope Center for Neurological Disorders and Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0436-17.2018
PubMed 
29766046
Published By 
Society for Neuroscience
History 
  • Received December 13, 2017
  • Revision received April 13, 2018
  • Accepted April 16, 2018
  • Published online April 25, 2018.
Copyright & Usage 
Copyright © 2018 Carlin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Dan Carlin1,
  2. Judith P. Golden2,
  3. Amit Mogha3,
  4. Vijay K. Samineni2,
  5. Kelly R. Monk3,*,
  6. Robert W. Gereau IV2 and
  7. Valeria Cavalli4
  1. 1Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110
  2. 2Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
  3. 3Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110
  4. 4Department of Neuroscience, Hope Center for Neurological Disorders and Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110
  1. Correspondence should be addressed to Valeria Cavalli, Department of Neuroscience, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, E-mail: cavalli{at}wustl.edu.
  • ↵* K. R. Monk’s present address: Vollum Institute, Oregon Health and Science University, Portland, OR 97221.

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Author contributions

  1. Author contributions: D.C., J.P.G., A.M., V.K.S., K.R.M., R.W.G., and V.C. designed research; D.C., J.P.G., V.K.S., and A.M. performed research; D.C., J.P.G., and V.K.S. analyzed data; D.C., J.P.G., R.W.G., and V.C. wrote the paper.

  • ↵* K. R. Monk’s present address: Vollum Institute, Oregon Health and Science University, Portland, OR 97221.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported in part by National Institutes of Health Grants DE022000 (to V.C.), NS099603 (to V.C.), and NS42595 (to R.W.G.) and by the McDonnell Center for Cellular Neurobiology at Washington University School of Medicine (K.R.M.).

Funding

  • NIH

    DE022000; NS099603; NS42595 
  • Mc Donnell Center for Cellular Neurobiology

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  • You are viewing the most recent version of this article.
  • previous version (April 25, 2018).

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Apr 2018235068
May 20181562337118
Jun 20189310067
Jul 2018554716
Aug 2018384441
Sep 2018193510
Oct 2018254017
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Feb 2019158618
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Jan 202035817
Feb 202084026
Mar 202034521
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Total 202052503190
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Apr 202156021
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May 202555320
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Jul 202596923
Aug 202565518
Sep 20251022426
Oct 202567626
Nov 20251210323
Dec 2025119741
Total 20251041012270
Jan 2026117626
Total 2026117626
Total249856581834
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Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat
Dan Carlin, Judith P. Golden, Amit Mogha, Vijay K. Samineni, Kelly R. Monk, Robert W. Gereau IV, Valeria Cavalli
eNeuro 25 April 2018, 5 (2) ENEURO.0436-17.2018; DOI: 10.1523/ENEURO.0436-17.2018

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Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat
Dan Carlin, Judith P. Golden, Amit Mogha, Vijay K. Samineni, Kelly R. Monk, Robert W. Gereau IV, Valeria Cavalli
eNeuro 25 April 2018, 5 (2) ENEURO.0436-17.2018; DOI: 10.1523/ENEURO.0436-17.2018
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Keywords

  • CGRP
  • DRG
  • mTOR
  • nociceptor
  • pain
  • Tsc2

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