Article Figures & Data
Figures
- Figure 1.
BDNF serum levels in a healthy cohort at Initial (n = 259) and 12-month (n = 226) visit. Measurements of the same subject are connected by a colored line to indicate percentage change in BDNF values between visits. Samples are separated on the x-axis by age in years.
- Figure 2.
BDNF serum levels and age of participant. The red broken line indicates the estimated serum BDNF for a given age in an average volunteer.
- Figure 3.
Correlation between BDNF values and platelet counts. A, BDNF values per platelet plotted against age. B, The red broken line indicates the estimated BDNF for a given platelet count in an average volunteer.
- Figure 4.
Correlation between BDNF values and hematocrit. The red broken line indicates the estimated BDNF for a given hematocrit in an average volunteer.
- Figure 5.
Cohort size estimation as a function of expected difference between two populations. Thick gray lines indicate a power of 80%; fine gray lines indicate a power of 90%. A, Cohort size required for a 20% difference in BDNF values. B, Cohort size required for a 10% difference in BDNF values.
- Figure 6.
Comparison of mean ELISA values with Western blotting determinations of the same serum samples. A, Western blotting used to quantify BDNF in two different serum samples (1 μl each) against a standard curve generated from three different quantities of recombinant BDNF with added BSA. B, Comparison between mean values obtained by Western blotting versus those obtained by ELISA. Error bars show SD, derived from at least three separate blots (WB) or three replicate wells in the same plate (ELISA).
Tables
Visit 1 Visit 2 N 259 226 Age in years [mean (SD)] 44.31 (11.26) 46.11 (10.80) Sex [males (%)] 81 (31.3) 74 (32.7) Time between samples in months [mean (SD)] 12.87 (2.21) Variable Gender N Mean (ng/ml) SD (ng/ml) p BDNF V1 F 178 32.85 8.57 0.7 M 81 32.34 7.82 BDNF V2 F 152 32.98 8.47 0.99 M 74 32.95 8.19
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