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Research ArticleNew Research, Sensory and Motor Systems

Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats

Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue and Makoto Tsuda
eNeuro 5 February 2018, 5 (1) ENEURO.0450-17.2018; https://doi.org/10.1523/ENEURO.0450-17.2018
Ryoichi Tashima
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Keisuke Koga
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Misuzu Sekine
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Kensho Kanehisa
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Yuta Kohro
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Keiko Tominaga
2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Katsuyuki Matsushita
2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Hidetoshi Tozaki-Saitoh
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Yugo Fukazawa
3Department of Brain Structure and Function, Research Center for Child Mental Development, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan
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  • ORCID record for Yugo Fukazawa
Kazuhide Inoue
2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Hiromu Yawo
4Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences, Sendai, Miyagi 980-8577, Japan
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  • ORCID record for Hiromu Yawo
Hidemasa Furue
5Department of Neurophysiology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
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Makoto Tsuda
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda
eNeuro 5 February 2018, 5 (1) ENEURO.0450-17.2018; DOI: 10.1523/ENEURO.0450-17.2018

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Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda
eNeuro 5 February 2018, 5 (1) ENEURO.0450-17.2018; DOI: 10.1523/ENEURO.0450-17.2018
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Keywords

  • Aβ fibers
  • aversion
  • neuropathic pain
  • optogenetics
  • primary afferents
  • spinal cord

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