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Research ArticleNew Research, Sensory and Motor Systems

Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats

Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue and Makoto Tsuda
eNeuro 5 February 2018, 5 (1) ENEURO.0450-17.2018; DOI: https://doi.org/10.1523/ENEURO.0450-17.2018
Ryoichi Tashima
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Keisuke Koga
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Misuzu Sekine
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Kensho Kanehisa
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Yuta Kohro
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Keiko Tominaga
2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Katsuyuki Matsushita
2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Hidetoshi Tozaki-Saitoh
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Yugo Fukazawa
3Department of Brain Structure and Function, Research Center for Child Mental Development, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan
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  • ORCID record for Yugo Fukazawa
Kazuhide Inoue
2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Hiromu Yawo
4Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences, Sendai, Miyagi 980-8577, Japan
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Hidemasa Furue
5Department of Neurophysiology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
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Makoto Tsuda
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0450-17.2018
PubMed 
29468190
Published By 
Society for Neuroscience
History 
  • Received December 23, 2017
  • Accepted January 25, 2018
  • Published online February 5, 2018.
Copyright & Usage 
Copyright © 2018 Tashima et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ryoichi Tashima1,
  2. Keisuke Koga1,
  3. Misuzu Sekine1,
  4. Kensho Kanehisa1,
  5. Yuta Kohro1,
  6. Keiko Tominaga2,
  7. Katsuyuki Matsushita2,
  8. Hidetoshi Tozaki-Saitoh1,
  9. Yugo Fukazawa3,
  10. Kazuhide Inoue2,
  11. Hiromu Yawo4,
  12. Hidemasa Furue5 and
  13. Makoto Tsuda1
  1. 1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  2. 2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  3. 3Department of Brain Structure and Function, Research Center for Child Mental Development, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan
  4. 4Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences, Sendai, Miyagi 980-8577, Japan
  5. 5Department of Neurophysiology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
  1. Correspondence should be addressed to either of the following: Makoto Tsuda, Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, E-mail: tsuda{at}phar.kyushu-u.ac.jp; or Hidemasa Furue, Department of Neurophysiology, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo 663-8501, Japan, E-mail: hi-furue{at}hyo-med.ac.jp.
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Author contributions

  1. Author contributions: R.T., K.Ko., H.F., and M.T. designed research; R.T., K.Ko., M.S., K.Ka., K.T., K.M., H.F., and M.T. performed research; R.T., K.Ko., Y.K., H.T.-S., Y.F., K.I., H.Y., H.F., and M.T. analyzed data; R.T., K.Ko., H.F., and M.T. wrote the paper.

  2. R.T. and K.Ko. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant JP15H02522 (to M.T.), the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research) from Japan Agency for Medical Research and Development (M.T.), the Takeda Science Foundation (M.T.), the Toray Science Foundation (M.T.), and The Nakatomi Foundation (M.T.). R.T. (17J03197) and K.Ko. (17J03680) are research fellows of the JSPS.

Funding

  • Japan Society for the Promotion of Science (JSPS)

    15H02522
  • Toray Science Foundation

  • Nakatomi Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 05, 2018).

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AbstractFullPdf
Feb 2018766140244
Mar 201823520688
Apr 2018167389157
May 2018867824
Jun 201880248138
Jul 2018586941
Aug 20186714385
Sep 20183310421
Oct 20182518029
Nov 20182726244
Dec 20182719434
Total 201815712013905
Jan 20191720313
Feb 20191017615
Mar 2019911512
Apr 201984919
May 2019106627
Jun 201997117
Jul 2019108724
Aug 2019129131
Oct 201959832
Nov 2019137620
Dec 201936921
Total 20191061101231
Jan 2020311734
Feb 202057137
Mar 202036116
May 202037426
Jun 2020511933
Jul 202028322
Aug 202056518
Sep 202058031
Oct 2020612538
Nov 2020010829
Dec 2020411427
Total 2020411017311
Jan 2021212726
Feb 202128427
Mar 2021611328
Apr 202149327
May 202119445
Jun 202128918
Jul 202127219
Aug 202148022
Sep 202129723
Oct 202129931
Nov 2021012736
Dec 202108125
Total 2021271156327
Jan 202238624
Feb 202237524
Mar 2022111531
Apr 2022215957
May 2022412131
Jun 2022111631
Jul 202206618
Aug 202228114
Sep 2022011027
Oct 2022311122
Nov 202238326
Dec 202227119
Total 2022241194324
Jan 202346915
Feb 202309126
Mar 202336113
Apr 202328212
May 202333615
Total 20231233981
Total178168202179
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Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda
eNeuro 5 February 2018, 5 (1) ENEURO.0450-17.2018; DOI: 10.1523/ENEURO.0450-17.2018

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Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda
eNeuro 5 February 2018, 5 (1) ENEURO.0450-17.2018; DOI: 10.1523/ENEURO.0450-17.2018
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Keywords

  • Aβ fibers
  • aversion
  • neuropathic pain
  • optogenetics
  • primary afferents
  • spinal cord

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