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Research ArticleNew Research, Sensory and Motor Systems

Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats

Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue and Makoto Tsuda
eNeuro 5 February 2018, 5 (1) ENEURO.0450-17.2018; https://doi.org/10.1523/ENEURO.0450-17.2018
Ryoichi Tashima
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Keisuke Koga
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Misuzu Sekine
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Kensho Kanehisa
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Yuta Kohro
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Keiko Tominaga
2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Katsuyuki Matsushita
2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Hidetoshi Tozaki-Saitoh
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Yugo Fukazawa
3Department of Brain Structure and Function, Research Center for Child Mental Development, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan
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  • ORCID record for Yugo Fukazawa
Kazuhide Inoue
2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Hiromu Yawo
4Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences, Sendai, Miyagi 980-8577, Japan
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Hidemasa Furue
5Department of Neurophysiology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
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Makoto Tsuda
1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0450-17.2018
PubMed 
29468190
Published By 
Society for Neuroscience
History 
  • Received December 23, 2017
  • Accepted January 25, 2018
  • Published online February 5, 2018.
Copyright & Usage 
Copyright © 2018 Tashima et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ryoichi Tashima1,
  2. Keisuke Koga1,
  3. Misuzu Sekine1,
  4. Kensho Kanehisa1,
  5. Yuta Kohro1,
  6. Keiko Tominaga2,
  7. Katsuyuki Matsushita2,
  8. Hidetoshi Tozaki-Saitoh1,
  9. Yugo Fukazawa3,
  10. Kazuhide Inoue2,
  11. Hiromu Yawo4,
  12. Hidemasa Furue5 and
  13. Makoto Tsuda1
  1. 1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  2. 2Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  3. 3Department of Brain Structure and Function, Research Center for Child Mental Development, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan
  4. 4Department of Developmental Biology and Neuroscience, Tohoku University Graduate School of Life Sciences, Sendai, Miyagi 980-8577, Japan
  5. 5Department of Neurophysiology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
  1. Correspondence should be addressed to either of the following: Makoto Tsuda, Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, E-mail: tsuda{at}phar.kyushu-u.ac.jp; or Hidemasa Furue, Department of Neurophysiology, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo 663-8501, Japan, E-mail: hi-furue{at}hyo-med.ac.jp.
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Author contributions

  1. Author contributions: R.T., K.Ko., H.F., and M.T. designed research; R.T., K.Ko., M.S., K.Ka., K.T., K.M., H.F., and M.T. performed research; R.T., K.Ko., Y.K., H.T.-S., Y.F., K.I., H.Y., H.F., and M.T. analyzed data; R.T., K.Ko., H.F., and M.T. wrote the paper.

  2. R.T. and K.Ko. contributed equally to this work.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant JP15H02522 (to M.T.), the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research) from Japan Agency for Medical Research and Development (M.T.), the Takeda Science Foundation (M.T.), the Toray Science Foundation (M.T.), and The Nakatomi Foundation (M.T.). R.T. (17J03197) and K.Ko. (17J03680) are research fellows of the JSPS.

Funding

  • Japan Society for the Promotion of Science (JSPS)

    15H02522
  • Toray Science Foundation

  • Nakatomi Foundation

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  • You are viewing the most recent version of this article.
  • previous version (February 05, 2018).

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Feb 2018766140244
Mar 201823520688
Apr 2018167389157
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Jun 201880248138
Jul 2018586941
Aug 20186714385
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Total 201815712013905
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May 2019106627
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Feb 2025813928
Mar 2025611530
Apr 202539123
May 202588334
Jun 20252317
Total 202532558156
Total1984104022944
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Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda
eNeuro 5 February 2018, 5 (1) ENEURO.0450-17.2018; DOI: 10.1523/ENEURO.0450-17.2018

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Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda
eNeuro 5 February 2018, 5 (1) ENEURO.0450-17.2018; DOI: 10.1523/ENEURO.0450-17.2018
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Keywords

  • Aβ fibers
  • aversion
  • neuropathic pain
  • optogenetics
  • primary afferents
  • spinal cord

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