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Research ArticleNew Research, Disorders of the Nervous System

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease

Huei-Bin Wang, Dawn H. Loh, Daniel S. Whittaker, Tamara Cutler, David Howland and Christopher S. Colwell
eNeuro 2 January 2018, 5 (1) ENEURO.0431-17.2017; https://doi.org/10.1523/ENEURO.0431-17.2017
Huei-Bin Wang
1Department of Psychiatry and Biobehavioral Sciences, University of California - Los Angeles, Los Angeles, CA 90024-1759
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Dawn H. Loh
1Department of Psychiatry and Biobehavioral Sciences, University of California - Los Angeles, Los Angeles, CA 90024-1759
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Daniel S. Whittaker
1Department of Psychiatry and Biobehavioral Sciences, University of California - Los Angeles, Los Angeles, CA 90024-1759
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Tamara Cutler
1Department of Psychiatry and Biobehavioral Sciences, University of California - Los Angeles, Los Angeles, CA 90024-1759
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David Howland
2CHDI Foundation, Princeton, NJ 08540
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Christopher S. Colwell
1Department of Psychiatry and Biobehavioral Sciences, University of California - Los Angeles, Los Angeles, CA 90024-1759
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0431-17.2017
PubMed 
29302618
Published By 
Society for Neuroscience
History 
  • Received December 11, 2017
  • Accepted December 12, 2017
  • Published online January 2, 2018.
Copyright & Usage 
Copyright © 2018 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Huei-Bin Wang1,*,
  2. Dawn H. Loh1,*,
  3. Daniel S. Whittaker1,
  4. Tamara Cutler1,
  5. David Howland2 and
  6. Christopher S. Colwell1
  1. 1Department of Psychiatry and Biobehavioral Sciences, University of California - Los Angeles, Los Angeles, CA 90024-1759
  2. 2CHDI Foundation, Princeton, NJ 08540
  1. Correspondence should be addressed to Christopher S. Colwell at E-mail: ccolwell{at}mednet.ucla.edu.
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Author contributions

  1. Author contributions: H.-B.W., D.S.W., D.H.L., D.H., and C.S.C. design research; H.-B.W., T.C., and D.S.W. performed research; H.-B.W. and C.S.C. analyzed data; H.-B.W. and C.S.C. wrote the paper.

  2. ↵* H.B.W. and D.H.L. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was support by the CHDI Foundation Grant A-7293.

Funding

  • CHDI Foundation (CHDI)

    A-7293

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Jan 201812241304218
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May 201883432215
Jun 20185874657
Jul 2018669330
Aug 2018369466
Sep 2018306316
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Jan 20192224119
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Mar 2019819118
Apr 20191111916
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Jun 201987823
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Aug 201978323
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Jul 20205498
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Oct 2020615537
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Total 2020711245262
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Feb 2021419326
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Apr 2021910419
May 2021209216
Jun 202139113
Jul 202139220
Aug 2021512020
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May 2025111521
Jun 2025410417
Jul 2025310728
Aug 2025611129
Sep 20251217320
Oct 20251311025
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Dec 20251313328
Total 2025841455300
Jan 20261711614
Total 20261711614
Total2504199032530
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Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease
Huei-Bin Wang, Dawn H. Loh, Daniel S. Whittaker, Tamara Cutler, David Howland, Christopher S. Colwell
eNeuro 2 January 2018, 5 (1) ENEURO.0431-17.2017; DOI: 10.1523/ENEURO.0431-17.2017

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Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease
Huei-Bin Wang, Dawn H. Loh, Daniel S. Whittaker, Tamara Cutler, David Howland, Christopher S. Colwell
eNeuro 2 January 2018, 5 (1) ENEURO.0431-17.2017; DOI: 10.1523/ENEURO.0431-17.2017
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Keywords

  • time-restricted feeding
  • fast/feed cycle
  • circadian rhythms
  • Huntington’s disease
  • Q175

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