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Research ArticleNew Research, Neuronal Excitability

Activity-Dependent Inhibitory Synapse Scaling Is Determined by Gephyrin Phosphorylation and Subsequent Regulation of GABAA Receptor Diffusion

Sereina Battaglia, Marianne Renner, Marion Russeau, Etienne Côme, Shiva K. Tyagarajan and Sabine Lévi
eNeuro 11 January 2018, 5 (1) ENEURO.0203-17.2017; https://doi.org/10.1523/ENEURO.0203-17.2017
Sereina Battaglia
4Institute of Pharmacology and Toxicology, University of Zürich, Zurich, 8057, Switzerland
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Marianne Renner
1 INSERM UMR-S, Paris, 75005, France
2 Université Pierre et Marie Curie, Paris, 75005, France
3 Institut du Fer a Moulin, Paris, 75005, France
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Marion Russeau
1 INSERM UMR-S, Paris, 75005, France
2 Université Pierre et Marie Curie, Paris, 75005, France
3 Institut du Fer a Moulin, Paris, 75005, France
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Etienne Côme
1 INSERM UMR-S, Paris, 75005, France
2 Université Pierre et Marie Curie, Paris, 75005, France
3 Institut du Fer a Moulin, Paris, 75005, France
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Shiva K. Tyagarajan
4Institute of Pharmacology and Toxicology, University of Zürich, Zurich, 8057, Switzerland
5 Center for Neuroscience Zurich, Zurich, 8057, Switzerland
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Sabine Lévi
1 INSERM UMR-S, Paris, 75005, France
2 Université Pierre et Marie Curie, Paris, 75005, France
3 Institut du Fer a Moulin, Paris, 75005, France
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0203-17.2017
PubMed 
29379879
Published By 
Society for Neuroscience
History 
  • Received June 9, 2017
  • Revision received December 14, 2017
  • Accepted December 21, 2017
  • Published online January 11, 2018.
Copyright & Usage 
Copyright © 2018 Battaglia et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sereina Battaglia4,
  2. Marianne Renner1,2,3,
  3. Marion Russeau1,2,3,
  4. Etienne Côme1,2,3,
  5. Shiva K. Tyagarajan4,5,* and
  6. Sabine Lévi1,2,3,*
  1. 1 INSERM UMR-S, Paris, 75005, France
  2. 2 Université Pierre et Marie Curie, Paris, 75005, France
  3. 3 Institut du Fer a Moulin, Paris, 75005, France
  4. 4Institute of Pharmacology and Toxicology, University of Zürich, Zurich, 8057, Switzerland
  5. 5 Center for Neuroscience Zurich, Zurich, 8057, Switzerland
  1. Correspondence should be addressed to either of the following: Sabine Lévi, INSERM-UPMC UMR-S 839, 17 rue du Fer a Moulin, 75005 Paris, France. E-mail: sabine.levi{at}inserm.fr; or Shiva Tyagarajan, Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, 8057 Zurich, CH, Switzerland. E-mail: tyagarajan{at}pharma.uzh.ch.
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Author contributions

  1. Author contributions: SL and SKT conceptualized the project and designed the experiments. SL supervised the experimental work. SB, EC, and MRu performed immunofluorescence and SPT experiments and analyzed the data together with SL. MRu prepared primary hippocampal neurons. MRe performed the superresolution experiments, developed data analysis tools, and analyzed the data. SL and SKT wrote the manuscript.

Disclosures

  • Authors report no conflict of interest.

  • This work was supported in part by INSERM, Sorbonne Université-UPMC, LabEx Biopsy to SL, Olgamyenfisch Grant to SKT, and University of Zurich internal funding to SKT. EC is the recipient of a doctoral fellowship from the Université Pierre and Marie Curie. STORM/PALM equipment at the IFM was supported by DIM NeRF from Région Ile-de-France and by the FRC/Rotary ‘Espoir en tête.’ The Lévi lab is affiliated with the Paris School of Neuroscience (ENP) and the Bio-Psy Laboratory of Excellence.

  • ↵* S.K.T. and S.L. are co-senior authors.

Funding

  • Institut National de la Santé et de la Recherche Médicale (Inserm)

  • Labex Biopsy

  • Olgamyenfisch grant

  • University of Zurich internal funding

  • Fédération pour la Recherche sur le Cerveau (FRC)

  • Université Pierre et Marie Curie (UPMC)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 11, 2018).

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AbstractFullPdf
Jan 2018721136128
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Sep 202065126
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Total 202025477217
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Feb 202116135
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Apr 202127221
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Jan 202516520
Feb 202566319
Mar 202526319
Apr 20251556
May 202505515
Jun 202512513
Total 20251132692
Total156673941967
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Activity-Dependent Inhibitory Synapse Scaling Is Determined by Gephyrin Phosphorylation and Subsequent Regulation of GABAA Receptor Diffusion
Sereina Battaglia, Marianne Renner, Marion Russeau, Etienne Côme, Shiva K. Tyagarajan, Sabine Lévi
eNeuro 11 January 2018, 5 (1) ENEURO.0203-17.2017; DOI: 10.1523/ENEURO.0203-17.2017

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Activity-Dependent Inhibitory Synapse Scaling Is Determined by Gephyrin Phosphorylation and Subsequent Regulation of GABAA Receptor Diffusion
Sereina Battaglia, Marianne Renner, Marion Russeau, Etienne Côme, Shiva K. Tyagarajan, Sabine Lévi
eNeuro 11 January 2018, 5 (1) ENEURO.0203-17.2017; DOI: 10.1523/ENEURO.0203-17.2017
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Keywords

  • GABAA receptor
  • homeostatic plasticity
  • PALM
  • post-translation modification
  • single particle tracking

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