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Research ArticleNew Research, Cognition and Behavior

Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females

S. D. Dolzani, M. V. Baratta, J. M. Moss, N. L. Leslie, S. G. Tilden, A. T. Sørensen, L. R. Watkins, Y. Lin and S. F. Maier
eNeuro 26 February 2018, 5 (1) ENEURO.0025-18.2018; https://doi.org/10.1523/ENEURO.0025-18.2018
S. D. Dolzani
1Department of Psychology and Neuroscience and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309
2Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO 80309
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  • ORCID record for S. D. Dolzani
M. V. Baratta
1Department of Psychology and Neuroscience and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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J. M. Moss
1Department of Psychology and Neuroscience and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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N. L. Leslie
1Department of Psychology and Neuroscience and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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S. G. Tilden
1Department of Psychology and Neuroscience and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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A. T. Sørensen
3Department of Neuroscience, University of Copenhagen, Copenhagen, 1165 Denmark
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L. R. Watkins
1Department of Psychology and Neuroscience and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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Y. Lin
4McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139
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S. F. Maier
1Department of Psychology and Neuroscience and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0025-18.2018
PubMed 
29516036
Published By 
Society for Neuroscience
History 
  • Received January 12, 2018
  • Revision received January 23, 2018
  • Accepted February 5, 2018
  • Published online February 26, 2018.
Copyright & Usage 
Copyright © 2018 Dolzani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. S. D. Dolzani1,2,
  2. M. V. Baratta1,
  3. J. M. Moss1,
  4. N. L. Leslie1,
  5. S. G. Tilden1,
  6. A. T. Sørensen3,
  7. L. R. Watkins1,
  8. Y. Lin4 and
  9. S. F. Maier1
  1. 1Department of Psychology and Neuroscience and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309
  2. 2Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO 80309
  3. 3Department of Neuroscience, University of Copenhagen, Copenhagen, 1165 Denmark
  4. 4McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139
  1. Correspondence should be addressed to Samuel Dolzani, University of Colorado Boulder, Department of Psychology and Neuroscience, Muenzinger D244, UCB 345, Boulder, CO 80309. E-mail: sam.dolzani{at}colorado.edu.
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Author contributions

  1. Author contributions: S.D.D., M.V.B., L.R.W., and S.F.M. designed research; S.D.D., M.V.B., J.M.R., N.L.S., and S.G.T. performed research; S.D.D. and J.M.M. analyzed data; A.T.S. and Y.L. contributed unpublished reagents/analytic tools; S.D.D. and S.F.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants T32 MH016880 (to S.D.D.), R01 MH050479 (to S.F.M.), and R21 MH106817 (to M.V.B.).

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    T32 MH016880; MH050479

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 26, 2018).

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Feb 2018252064
Mar 20181221336225
Apr 2018213502134
May 201811310733
Jun 20187812478
Jul 2018438024
Aug 20183445448
Sep 2018197616
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Total 201820332447688
Jan 20191021218
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May 201956530
Jun 20198579
Jul 201937110
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Jan 202074912
Feb 202063627
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May 202034219
Jun 202036713
Jul 202022928
Aug 20203258
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Oct 202057023
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Total 202056522204
Jan 202126233
Feb 202124110
Mar 202198243
Apr 202126616
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Feb 202264823
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May 202516318
Jun 2025108126
Jul 202546017
Aug 202576222
Sep 2025109515
Oct 2025138622
Nov 20251510028
Dec 2025910027
Total 202586913241
Jan 20261512627
Feb 202691145
Total 20262424032
Total245979292192
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Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females
S. D. Dolzani, M. V. Baratta, J. M. Moss, N. L. Leslie, S. G. Tilden, A. T. Sørensen, L. R. Watkins, Y. Lin, S. F. Maier
eNeuro 26 February 2018, 5 (1) ENEURO.0025-18.2018; DOI: 10.1523/ENEURO.0025-18.2018

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Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females
S. D. Dolzani, M. V. Baratta, J. M. Moss, N. L. Leslie, S. G. Tilden, A. T. Sørensen, L. R. Watkins, Y. Lin, S. F. Maier
eNeuro 26 February 2018, 5 (1) ENEURO.0025-18.2018; DOI: 10.1523/ENEURO.0025-18.2018
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Keywords

  • dorsal raphe nucleus
  • ketamine
  • prefrontal cortex
  • resilience
  • serotonin
  • stress

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