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Research ArticleNew Research, Disorders of the Nervous System

Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-Null Mouse Model of Christianson Syndrome

Meiyu Xu, Qing Ouyang, Jingyi Gong, Matthew F. Pescosolido, Brandon S. Pruett, Sasmita Mishra, Michael Schmidt, Richard N. Jones, Ece D. Gamsiz Uzun, Sofia B. Lizarraga and Eric M. Morrow
eNeuro 26 December 2017, 4 (6) ENEURO.0388-17.2017; DOI: https://doi.org/10.1523/ENEURO.0388-17.2017
Meiyu Xu
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Brown Institute for Brain Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
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Qing Ouyang
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Brown Institute for Brain Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
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Jingyi Gong
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Brown Institute for Brain Science, Brown University, Providence, RI 02912
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Matthew F. Pescosolido
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Brown Institute for Brain Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
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Brandon S. Pruett
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
4Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI 02912
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  • ORCID record for Brandon S. Pruett
Sasmita Mishra
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Brown Institute for Brain Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
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Michael Schmidt
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Brown Institute for Brain Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
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Richard N. Jones
4Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI 02912
5Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02912
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Ece D. Gamsiz Uzun
6Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02912
7Center for Computational Molecular Biology, Brown University, Providence, RI 02912
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Sofia B. Lizarraga
8Department of Biological Sciences, University of South Carolina, Columbia, SC 29208
9Center for Childhood Neurotherapeutics, University of South Carolina, Columbia, SC 29208
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Eric M. Morrow
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Brown Institute for Brain Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
4Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI 02912
10Hassenfeld Child Health Innovation Institute, Brown University, Providence, RI 02912
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0388-17.2017
PubMed 
29349289
Published By 
Society for Neuroscience
History 
  • Received November 13, 2017
  • Revision received December 12, 2017
  • Accepted December 17, 2017
  • Published online December 26, 2017.
Copyright & Usage 
Copyright © 2018 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Meiyu Xu1,2,3,
  2. Qing Ouyang1,2,3,
  3. Jingyi Gong1,2,
  4. Matthew F. Pescosolido1,2,3,
  5. Brandon S. Pruett3,4,
  6. Sasmita Mishra1,2,3,
  7. Michael Schmidt1,2,3,
  8. Richard N. Jones4,5,
  9. Ece D. Gamsiz Uzun6,7,
  10. Sofia B. Lizarraga8,9 and
  11. Eric M. Morrow1,2,3,4,10
  1. 1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
  2. 2Brown Institute for Brain Science, Brown University, Providence, RI 02912
  3. 3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
  4. 4Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI 02912
  5. 5Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02912
  6. 6Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02912
  7. 7Center for Computational Molecular Biology, Brown University, Providence, RI 02912
  8. 8Department of Biological Sciences, University of South Carolina, Columbia, SC 29208
  9. 9Center for Childhood Neurotherapeutics, University of South Carolina, Columbia, SC 29208
  10. 10Hassenfeld Child Health Innovation Institute, Brown University, Providence, RI 02912
  1. Correspondence should be addressed to Eric M. Morrow, PhD, MD, Brown University, Laboratories for Molecular Medicine, 70 Ship Street, Box G-E4, Providence, RI 02912. E-mail: eric_morrow{at}brown.edu.
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Author contributions

  1. Author Contributions: MX, QO, JG, MFP, SBL, and EMM designed research; MX, QO, JG, MFP, SM, MS, SBL, and EMM performed research; MX, QO, JG, MFP, BSP, RNJ, EDGU, SBL, and EMM analyzed data; and MX, QO, JG, MFP, BSP, MS, SBL, and EMM wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported in part by the following: National Institutes of Health/National Institute of Mental Health grants R01MH105442, R01MH102418, and R21MH115392 (to EMM) and R25MH101076 (BSP); and National Institutes of Health/National Institute of Neurological Disorders and Stroke grant F31NS093880 (to MFP).

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01MH105442; R01MH102418; R21MH115392; R25MH101076
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    F31NS093880

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 26, 2017).

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AbstractFullPdf
Dec 201788014
Total 201788014
Jan 201843075127
Feb 20181016232
Mar 2018585425
Apr 2018497433
May 2018518332
Jun 2018307544
Jul 2018283715
Aug 2018244817
Sep 2018215114
Oct 20182410924
Nov 20181711012
Dec 20181632514
Total 20188491103389
Jan 20191016315
Feb 20191217116
Mar 20191311811
Apr 201986714
May 201996116
Jun 201955016
Jul 201915616
Aug 201983920
Oct 2019135413
Nov 201965814
Dec 201994621
Total 201994883172
Jan 202085213
Feb 202095323
Mar 202084315
May 202062922
Jun 202052110
Jul 202073518
Aug 202022317
Sep 202064410
Oct 2020105311
Nov 202035217
Dec 202058512
Total 202069490168
Jan 202116013
Feb 20212414
Mar 202127516
Apr 202135726
May 20212546
Jun 202115710
Jul 202137043
Aug 202159222
Sep 202116314
Oct 202166630
Nov 202125334
Dec 20210547
Total 202128742225
Jan 202238411
Feb 20225378
Mar 202214819
Apr 202214417
May 202206927
Jun 202225011
Jul 202233310
Aug 202213215
Sep 202233217
Oct 202204219
Nov 202223916
Dec 202223512
Total 202223545182
Jan 202333612
Feb 20231354
Mar 20231172
Total 202358818
Total115638511168
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Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-Null Mouse Model of Christianson Syndrome
Meiyu Xu, Qing Ouyang, Jingyi Gong, Matthew F. Pescosolido, Brandon S. Pruett, Sasmita Mishra, Michael Schmidt, Richard N. Jones, Ece D. Gamsiz Uzun, Sofia B. Lizarraga, Eric M. Morrow
eNeuro 26 December 2017, 4 (6) ENEURO.0388-17.2017; DOI: 10.1523/ENEURO.0388-17.2017

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Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-Null Mouse Model of Christianson Syndrome
Meiyu Xu, Qing Ouyang, Jingyi Gong, Matthew F. Pescosolido, Brandon S. Pruett, Sasmita Mishra, Michael Schmidt, Richard N. Jones, Ece D. Gamsiz Uzun, Sofia B. Lizarraga, Eric M. Morrow
eNeuro 26 December 2017, 4 (6) ENEURO.0388-17.2017; DOI: 10.1523/ENEURO.0388-17.2017
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Keywords

  • Christianson syndrome
  • Microglia
  • neurodegeneration
  • neurodevelopment
  • NHE6
  • SLC9A6

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