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Research ArticleOpinion, Disorders of the Nervous System

Seizure Forecasting from Idea to Reality. Outcomes of the My Seizure Gauge Epilepsy Innovation Institute Workshop

Sonya B. Dumanis, Jaqueline A. French, Christophe Bernard, Gregory A. Worrell and Brandy E. Fureman
eNeuro 14 December 2017, 4 (6) ENEURO.0349-17.2017; https://doi.org/10.1523/ENEURO.0349-17.2017
Sonya B. Dumanis
1Research and New Therapies, Epilepsy Foundation of America, Landover, MD 20784
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Jaqueline A. French
1Research and New Therapies, Epilepsy Foundation of America, Landover, MD 20784
2Department of Neurology, New York University, New York, NY 10003
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Christophe Bernard
3Aix Marseille University, INSERM, INS, Inst Neurosci Syst, Marseille, 13005, France
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Gregory A. Worrell
4Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, MN 55902
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Brandy E. Fureman
1Research and New Therapies, Epilepsy Foundation of America, Landover, MD 20784
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    Table 1.

    Potential measurements discussed at the Ei2 workshop that could enhance a seizure-forecasting algorithm

    • Mood*• Stress*• Compliance
    • Cortisol• Fatigue*• Illness*
    • Orexin• Irritability*• Food/alcohol intake
    • Patient self-prediction*• Sex hormones• Orientation (cognitive)
    • Electrical dermal activity• pH (brain)• Gait
    • Heart rate• Time of day*• Finer movements
    • Temperature/weather• Antiepileptic drug levels• Ketones
    • Respiration• Blood oxygen• Speech
    • Sleep cycle changes (sleep/wake staging)• Inflammatory markers• Body Temperature
    • Sleep quality• Glucose
    • External environment
    • These measurements could be collected in numerous ways. An asterisk indicates those that could be captured by patient diary, others could be measured through smartphone, biosensors, or through sweat collection.

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eneuro: 4 (6)
eNeuro
Vol. 4, Issue 6
November/December 2017
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Seizure Forecasting from Idea to Reality. Outcomes of the My Seizure Gauge Epilepsy Innovation Institute Workshop
Sonya B. Dumanis, Jaqueline A. French, Christophe Bernard, Gregory A. Worrell, Brandy E. Fureman
eNeuro 14 December 2017, 4 (6) ENEURO.0349-17.2017; DOI: 10.1523/ENEURO.0349-17.2017

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Seizure Forecasting from Idea to Reality. Outcomes of the My Seizure Gauge Epilepsy Innovation Institute Workshop
Sonya B. Dumanis, Jaqueline A. French, Christophe Bernard, Gregory A. Worrell, Brandy E. Fureman
eNeuro 14 December 2017, 4 (6) ENEURO.0349-17.2017; DOI: 10.1523/ENEURO.0349-17.2017
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  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Seizures Have Multi-Temporal Patterns on Ultradian, Circadian, and Multi-Day Time Scales
    • Multimodal Analysis of Seizure Events Coupling EEG with Non-EEG Measures May Enhance Seizure-Forecasting Algorithms
    • Individualization and Personalization of a Seizure-Forecasting Algorithm Is Necessary
    • Next Steps
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • Algorithm
  • Data Collection
  • epilepsy
  • multimodal input
  • seizure forecasting
  • Temporal Pattern

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