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Research ArticleNew Research, Disorders of the Nervous System

Activation of the Medial Prefrontal Cortex Reverses Cognitive and Respiratory Symptoms in a Mouse Model of Rett Syndrome

C. James Howell, Michael P. Sceniak, Min Lang, Wenceslas Krakowiecki, Fatimah E. Abouelsoud, Saloni U. Lad, Heping Yu and David M. Katz
eNeuro 21 December 2017, 4 (6) ENEURO.0277-17.2017; https://doi.org/10.1523/ENEURO.0277-17.2017
C. James Howell
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106
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Michael P. Sceniak
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106
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Min Lang
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106
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Wenceslas Krakowiecki
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106
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Fatimah E. Abouelsoud
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106
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Saloni U. Lad
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106
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Heping Yu
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106
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David M. Katz
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0277-17.2017
PubMed 
29333487
Published By 
Society for Neuroscience
History 
  • Received August 8, 2017
  • Revision received November 27, 2017
  • Accepted December 1, 2017
  • Published online December 21, 2017.
Copyright & Usage 
Copyright © 2018 Howell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. C. James Howell,
  2. Michael P. Sceniak,
  3. Min Lang,
  4. Wenceslas Krakowiecki,
  5. Fatimah E. Abouelsoud,
  6. Saloni U. Lad,
  7. Heping Yu and
  8. David M. Katz
  1. Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106
  1. Correspondence should be addressed to David M. Katz, Department of Neurosciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, E-mail: david.katz{at}case.edu.
  • M. P. Sceniak’s present address: University of Michigan 500 S State St., Ann Arbor, MI 48109.

View Full Text

Author contributions

  1. Author contributions: C.J.H., D.M.K., and M.P.S. designed research; C.J.H., M.P.S., S.U.L., and H.Y. performed research; C.J.H., M.P.S., M.L., W.K., and F.E.A. analyzed data; C.J.H. and D.M.K. wrote the paper.

  • M. P. Sceniak’s present address: University of Michigan 500 S State St., Ann Arbor, MI 48109.

View Abstract

Disclosures

  • D.M.K. is a founding advisor to ArRETT Neuroscience, a company focused on advancing treatments for patients with Rett syndrome. All other authors declare no competing financial interests.

  • This work was supported by National Institution of Neurological Disorders and Stroke Grants NS057398 (to D.M.K.) and NS098574-02 (to C.J.H.).

Funding

  • HHS | National Institutes of Health (NIH)

    NS057398; NS098574-02

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 21, 2017).

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Dec 2017245060
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Jan 2018489278183
Feb 20187515446
Mar 2018769123
Apr 20186211673
May 20184810029
Jun 2018329231
Jul 2018268516
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Apr 20218555
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Jul 202127328
Aug 20218633
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Jul 2025229421
Aug 202566326
Sep 20252018227
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Total 20251581065260
Jan 20263015615
Feb 20262526315
Mar 20262215140
Apr 20262722546
May 20263147
Total 2026107809123
Total182285102083
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Activation of the Medial Prefrontal Cortex Reverses Cognitive and Respiratory Symptoms in a Mouse Model of Rett Syndrome
C. James Howell, Michael P. Sceniak, Min Lang, Wenceslas Krakowiecki, Fatimah E. Abouelsoud, Saloni U. Lad, Heping Yu, David M. Katz
eNeuro 21 December 2017, 4 (6) ENEURO.0277-17.2017; DOI: 10.1523/ENEURO.0277-17.2017

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Activation of the Medial Prefrontal Cortex Reverses Cognitive and Respiratory Symptoms in a Mouse Model of Rett Syndrome
C. James Howell, Michael P. Sceniak, Min Lang, Wenceslas Krakowiecki, Fatimah E. Abouelsoud, Saloni U. Lad, Heping Yu, David M. Katz
eNeuro 21 December 2017, 4 (6) ENEURO.0277-17.2017; DOI: 10.1523/ENEURO.0277-17.2017
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Keywords

  • autism spectrum disorder
  • DREADD
  • Hypofrontality
  • MeCP2
  • memory
  • MPFC

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