Research ArticleNew Research, Neuronal Excitability

Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons

Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson and Merab Kokaia
eNeuro 7 December 2017, 4 (6) ENEURO.0172-17.2017; DOI: https://doi.org/10.1523/ENEURO.0172-17.2017

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0172-17.2017
PubMed 
29379872
Published By 
Society for Neuroscience
History 
  • Received May 17, 2017
  • Revision received October 9, 2017
  • Accepted October 31, 2017
  • Published online December 7, 2017.
Copyright & Usage 
Copyright © 2017 Sørensen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Andreas T. Sørensen,
  2. Marco Ledri,
  3. Miriam Melis,
  4. Litsa Nikitidou Ledri,
  5. My Andersson and
  6. Merab Kokaia
  1. Experimental Epilepsy Group, Epilepsy Center, Department of Clinical Sciences, Lund University Hospital, Lund 22184, Sweden
  1. Correspondence should be addressed to either of the following: Andreas T. Sørensen at the above address, E-mail: andreass{at}sund.ku.dk; or Merab Kokaia at the above address, E-mail: merab.kokaia{at}med.lu.se.

  • A. T. Sørensen’s present address: Molecular Neuropharmacology and Genetics Lab, Department of Neuroscience, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

  • Miriam Melis’s present address: Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy.

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Author contributions

  1. Author contribution: A.T.S., M.L., and M.K. designed research; A.T.S, M.L., M.M., L.N.L., and M.A. performed research; A.T.S. analyzed data; A.T.S., M.L., and M.K. wrote the paper.

  • A. T. Sørensen’s present address: Molecular Neuropharmacology and Genetics Lab, Department of Neuroscience, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

  • Miriam Melis’s present address: Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by a Lundbeckfonden Postdoctoral Fellowship (to A.T.S.), The Swedish Research Council Grant 2015-00353 (to M.L.), Marie Sklodowska Curie Actions Grant INCA 600398 (to M.L.), Regione Autonoma Sardegna fellowship (to M.M.), the Swedish Research Council Grant 2016-02605 (to M.A.), and the Swedish Research Council Grant K2013-61X-14603-11-5 (to M.K.).

Funding

  • Lundbeckfonden (Lundbeck Foundation)

  • Vetenskapsrådet (VR)

    2016-02605

  • Marie Curie Sklodowska Curie Action

    INCA 600398

  • Regione Autonoma Sardegna fellowship

  • Vetenskapsrådet

    2016-02605

Other Version

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Total92033641343
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eneuro: 4 (6)
eNeuro
Vol. 4, Issue 6
November/December 2017
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Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons
Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson, Merab Kokaia
eNeuro 7 December 2017, 4 (6) ENEURO.0172-17.2017; DOI: 10.1523/ENEURO.0172-17.2017
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