Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro

eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleNew Research, Neuronal Excitability

Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons

Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson and Merab Kokaia
eNeuro 7 December 2017, 4 (6) ENEURO.0172-17.2017; DOI: https://doi.org/10.1523/ENEURO.0172-17.2017
Andreas T. Sørensen
Experimental Epilepsy Group, Epilepsy Center, Department of Clinical Sciences, Lund University Hospital, Lund 22184, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Andreas T. Sørensen
Marco Ledri
Experimental Epilepsy Group, Epilepsy Center, Department of Clinical Sciences, Lund University Hospital, Lund 22184, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Marco Ledri
Miriam Melis
Experimental Epilepsy Group, Epilepsy Center, Department of Clinical Sciences, Lund University Hospital, Lund 22184, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Miriam Melis
Litsa Nikitidou Ledri
Experimental Epilepsy Group, Epilepsy Center, Department of Clinical Sciences, Lund University Hospital, Lund 22184, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
My Andersson
Experimental Epilepsy Group, Epilepsy Center, Department of Clinical Sciences, Lund University Hospital, Lund 22184, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for My Andersson
Merab Kokaia
Experimental Epilepsy Group, Epilepsy Center, Department of Clinical Sciences, Lund University Hospital, Lund 22184, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Merab Kokaia
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0172-17.2017
PubMed 
29379872
Published By 
Society for Neuroscience
History 
  • Received May 17, 2017
  • Revision received October 9, 2017
  • Accepted October 31, 2017
  • Published online December 7, 2017.
Copyright & Usage 
Copyright © 2017 Sørensen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Andreas T. Sørensen,
  2. Marco Ledri,
  3. Miriam Melis,
  4. Litsa Nikitidou Ledri,
  5. My Andersson and
  6. Merab Kokaia
  1. Experimental Epilepsy Group, Epilepsy Center, Department of Clinical Sciences, Lund University Hospital, Lund 22184, Sweden
  1. Correspondence should be addressed to either of the following: Andreas T. Sørensen at the above address, E-mail: andreass{at}sund.ku.dk; or Merab Kokaia at the above address, E-mail: merab.kokaia{at}med.lu.se.
  • A. T. Sørensen’s present address: Molecular Neuropharmacology and Genetics Lab, Department of Neuroscience, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

  • Miriam Melis’s present address: Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy.

View Full Text

Author contributions

  1. Author contribution: A.T.S., M.L., and M.K. designed research; A.T.S, M.L., M.M., L.N.L., and M.A. performed research; A.T.S. analyzed data; A.T.S., M.L., and M.K. wrote the paper.

  • A. T. Sørensen’s present address: Molecular Neuropharmacology and Genetics Lab, Department of Neuroscience, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

  • Miriam Melis’s present address: Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by a Lundbeckfonden Postdoctoral Fellowship (to A.T.S.), The Swedish Research Council Grant 2015-00353 (to M.L.), Marie Sklodowska Curie Actions Grant INCA 600398 (to M.L.), Regione Autonoma Sardegna fellowship (to M.M.), the Swedish Research Council Grant 2016-02605 (to M.A.), and the Swedish Research Council Grant K2013-61X-14603-11-5 (to M.K.).

Funding

  • Lundbeckfonden (Lundbeck Foundation)

  • Vetenskapsrådet (VR)

    2016-02605
  • Marie Curie Sklodowska Curie Action

    INCA 600398
  • Regione Autonoma Sardegna fellowship

  • Vetenskapsrådet

    2016-02605

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 07, 2017).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2023-01-27
to
E.g., 2023-01-27

Article usage: December 2017 to January 2023

AbstractFullPdf
Dec 20173190114
Total 20173190114
Jan 20181416456
Feb 2018747059
Mar 2018415013
Apr 2018469366
May 2018454625
Jun 2018345953
Jul 2018142412
Aug 2018224431
Sep 201810306
Oct 201879113
Nov 201891055
Dec 2018131005
Total 2018456776344
Jan 2019811312
Feb 2019511810
Mar 201998512
Apr 201966512
May 201974414
Jun 20195379
Jul 2019104611
Aug 201942815
Oct 201963916
Nov 201953112
Dec 201912810
Total 201966634133
Jan 20204278
Feb 202051515
Mar 202033620
May 202063213
Jun 202032712
Jul 20202153
Aug 20200185
Sep 202034314
Oct 202077925
Nov 202015712
Dec 202057517
Total 202039424144
Jan 202136619
Feb 202105914
Mar 202137429
Apr 202127216
May 202136617
Jun 202106424
Jul 202116022
Aug 202135434
Sep 202117031
Oct 202117637
Nov 202127142
Dec 2021210923
Total 202121841308
Jan 202207037
Feb 202234517
Mar 202206427
Apr 202206621
May 202226838
Jun 202225717
Jul 202204816
Aug 202244011
Sep 202213018
Oct 202225336
Nov 202204422
Dec 202256024
Total 202219645284
Jan 202304416
Total 202304416
Total92033641343
Back to top

In this issue

eneuro: 4 (6)
eNeuro
Vol. 4, Issue 6
November/December 2017
  • Table of Contents
  • Index by author
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons
Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson, Merab Kokaia
eNeuro 7 December 2017, 4 (6) ENEURO.0172-17.2017; DOI: 10.1523/ENEURO.0172-17.2017

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons
Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson, Merab Kokaia
eNeuro 7 December 2017, 4 (6) ENEURO.0172-17.2017; DOI: 10.1523/ENEURO.0172-17.2017
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • action potential threshold
  • chloride
  • eNpHR3.0
  • GABAA receptors
  • halorhodopsin
  • optogenetics

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

New Research

  • Brain FNDC5/irisin expression in patients and mouse models of major depression
  • Microglia maintain homeostatic conditions in the developing rostral migratory stream
  • Similar presynaptic action potential-calcium influx coupling in two types of large mossy fiber terminals innervating CA3 pyramidal cells and hilar mossy cells
Show more New Research

Neuronal Excitability

  • Similar presynaptic action potential-calcium influx coupling in two types of large mossy fiber terminals innervating CA3 pyramidal cells and hilar mossy cells
  • Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants
  • Chemogenetic Enhancement of cAMP Signaling Renders Hippocampal Synaptic Plasticity Resilient to the Impact of Acute Sleep Deprivation
Show more Neuronal Excitability

Subjects

  • Neuronal Excitability

  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2023 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.