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Research ArticleNew Research, Neuronal Excitability

Cell-Specific RNA Binding Protein Rbfox2 Regulates CaV2.2 mRNA Exon Composition and CaV2.2 Current Size

Summer E. Allen, Cecilia P. Toro, Arturo Andrade, Eduardo J. López-Soto, Sylvia Denome and Diane Lipscombe
eNeuro 29 September 2017, 4 (5) ENEURO.0332-16.2017; https://doi.org/10.1523/ENEURO.0332-16.2017
Summer E. Allen
1Department of Neuroscience, and the Brown Institute for Brain Science, Brown University, Providence, RI 02912
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Cecilia P. Toro
2Department of Biology, Linfield College, McMinnville, OR 97128
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Arturo Andrade
3Department of Biological Sciences, University of New Hampshire, Durham, NH 03824
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Eduardo J. López-Soto
1Department of Neuroscience, and the Brown Institute for Brain Science, Brown University, Providence, RI 02912
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Sylvia Denome
1Department of Neuroscience, and the Brown Institute for Brain Science, Brown University, Providence, RI 02912
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Diane Lipscombe
1Department of Neuroscience, and the Brown Institute for Brain Science, Brown University, Providence, RI 02912
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0332-16.2017
PubMed 
29067356
Published By 
Society for Neuroscience
History 
  • Received October 31, 2016
  • Revision received September 14, 2017
  • Accepted September 21, 2017
  • Published online September 29, 2017.
Copyright & Usage 
Copyright © 2017 Allen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Summer E. Allen1,*,
  2. Cecilia P. Toro2,*,
  3. Arturo Andrade3,*,
  4. Eduardo J. López-Soto1,
  5. Sylvia Denome1 and
  6. Diane Lipscombe1
  1. 1Department of Neuroscience, and the Brown Institute for Brain Science, Brown University, Providence, RI 02912
  2. 2Department of Biology, Linfield College, McMinnville, OR 97128
  3. 3Department of Biological Sciences, University of New Hampshire, Durham, NH 03824
  1. Correspondence should be addressed to Diane Lipscombe, at the above address, E-mail: diane_lipscombe{at}brown.edu.
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Author contributions

  1. Author contributions: S.E.A., C.P.T., A.A., S.D., and D.L. designed research; S.E.A., C.P.T., A.A., S.D., and E.J.L.-S. performed research; S.E.A., C.P.T., A.A., and D.L. wrote the paper. All authors analyzed data.

  2. ↵* S.A.E., C.P.T., and A.A. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Sidney Frank Predoctoral Fellowship (C.P.T.), the Charles A. Dana Interdisciplinary Fellowship (S.E.A.), and National Institutes of Health Grants F31NS066691 (to S.E.A.), F31NS066712 (to C.P.T.), NS29967 (to D.L.), NS55251 (to D.L.), and R00 MH099405 (to A.A.).

Funding

  • Sidney Frank Predoctoral Fewlloship

  • Charles A Dana Interdisciplinary Fellowship

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    F31NS066691; F31NS066712; NS55251
  • HHS | NIH | National Institute of Mental Health (NIMH)

    R00 MH099405

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 29, 2017).

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AbstractFullPdf
Sep 20172403
Oct 2017655160137
Nov 2017117130101
Dec 20175637020
Total 2017852660261
Jan 20183710922
Feb 2018263016
Mar 2018202718
Apr 2018154221
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Jul 2018134923
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Total 2018231563238
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Mar 201972838
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Feb 202009114
Mar 20203784
May 202041354
Jun 20203862
Jul 20202895
Aug 20201418
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Total 20203094779
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Feb 20212632
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Apr 2021116211
May 20213998
Jun 202107210
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Total 202133973150
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Total 202465671183
Jan 202516220
Feb 202588315
Mar 202526925
Apr 202506411
May 20253256
Total 20251430377
Total133871391398
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Cell-Specific RNA Binding Protein Rbfox2 Regulates CaV2.2 mRNA Exon Composition and CaV2.2 Current Size
Summer E. Allen, Cecilia P. Toro, Arturo Andrade, Eduardo J. López-Soto, Sylvia Denome, Diane Lipscombe
eNeuro 29 September 2017, 4 (5) ENEURO.0332-16.2017; DOI: 10.1523/ENEURO.0332-16.2017

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Cell-Specific RNA Binding Protein Rbfox2 Regulates CaV2.2 mRNA Exon Composition and CaV2.2 Current Size
Summer E. Allen, Cecilia P. Toro, Arturo Andrade, Eduardo J. López-Soto, Sylvia Denome, Diane Lipscombe
eNeuro 29 September 2017, 4 (5) ENEURO.0332-16.2017; DOI: 10.1523/ENEURO.0332-16.2017
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Keywords

  • alternative splicing
  • calcium channels
  • N-type
  • rbfox2
  • Splicing Factors
  • Superior Cervical Ganglia

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