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Review, Disorders of the Nervous System

Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives

Clement Hamani, Gerson Florence, Helmut Heinsen, Birgit R. Plantinga, Yasin Temel, Kamil Uludag, Eduardo Alho, Manoel J. Teixeira, Edson Amaro and Erich T. Fonoff
eNeuro 13 September 2017, 4 (5) ENEURO.0140-17.2017; https://doi.org/10.1523/ENEURO.0140-17.2017
Clement Hamani
1Division of Neurosurgery Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
2Division of Neuroimaging, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
4Division of Neurosurgery, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil
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Gerson Florence
4Division of Neurosurgery, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil
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Helmut Heinsen
3Department of Radiology, University of São Paulo Medical School, São Paulo, Brazil
9Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Clinic of Würzburg, Würzburg, Germany
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Birgit R. Plantinga
5Department of Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, The Netherlands
6Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands
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Yasin Temel
6Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands
7Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands
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  • ORCID record for Yasin Temel
Kamil Uludag
8Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands
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Eduardo Alho
4Division of Neurosurgery, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil
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Manoel J. Teixeira
4Division of Neurosurgery, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil
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Edson Amaro
3Department of Radiology, University of São Paulo Medical School, São Paulo, Brazil
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Erich T. Fonoff
4Division of Neurosurgery, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil
10Instituto de Ensino e Pesquisa Hospital Sírio-Libanês, São Paulo, Brazil
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0140-17.2017
PubMed 
28966978
Published By 
Society for Neuroscience
History 
  • Received April 21, 2017
  • Revision received July 7, 2017
  • Accepted August 6, 2017
  • Published online September 13, 2017.
Copyright & Usage 
Copyright © 2017 Hamani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Clement Hamani1,2,4,
  2. Gerson Florence4,
  3. Helmut Heinsen3,9,
  4. Birgit R. Plantinga5,6,
  5. Yasin Temel6,7,
  6. Kamil Uludag8,
  7. Eduardo Alho4,
  8. Manoel J. Teixeira4,
  9. Edson Amaro3 and
  10. Erich T. Fonoff4,10
  1. 1Division of Neurosurgery Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
  2. 2Division of Neuroimaging, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
  3. 3Department of Radiology, University of São Paulo Medical School, São Paulo, Brazil
  4. 4Division of Neurosurgery, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil
  5. 5Department of Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, The Netherlands
  6. 6Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands
  7. 7Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands
  8. 8Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands
  9. 9Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Clinic of Würzburg, Würzburg, Germany
  10. 10Instituto de Ensino e Pesquisa Hospital Sírio-Libanês, São Paulo, Brazil
  1. Correspondence should be addressed to Clement Hamani, Division of Neurosurgery, Sunnybrook Health Sciences Centre, 2075 Bayview av S wing S126, Toronto, ON, M4N 3M5, Canada, E mail: clement.hamani{at}sunnybrook.ca.
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Author contributions

  1. Author contributions: C.H., G.F., H.H., B.R.P., Y.T., K.U., E.Al., M.J.T., E.Am., and E.T.F. wrote the paper.

Disclosures

  • C.H. received honoraria form Medtronic and St Jude Medical. All other authors declare no competing financial interests.

  • This work was supported in part with funds from Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP and Projeto PROADI SUS - IEP Hospital Sírio-Libanês.

Funding

  • None

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 13, 2017).

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Sep 201768416236
Oct 2017410415327
Nov 2017164235195
Dec 20177240257
Total 201713301068815
Jan 2018578345
Feb 2018539053
Mar 20188411060
Apr 201898288120
May 20189072451
Jun 201882890138
Jul 20186931038
Aug 201860214141
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Total 20187164357840
Jan 20191541945
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Apr 2019914450
May 20191217966
Jun 2019717346
Jul 2019822476
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Oct 20191118743
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Total 20191232505565
Jan 2020615235
Feb 2020616346
Mar 2020215354
May 2020823278
Jun 2020614671
Jul 2020412744
Aug 2020010821
Sep 2020915563
Oct 2020521564
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Dec 2020315345
Total 2020501746579
Jan 20211210111
Feb 2021015059
Mar 2021218156
Apr 2021117554
May 2021613659
Jun 2021412133
Jul 2021012546
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Total 2021291817693
Jan 2022115035
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Jun 2022017647
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Aug 2022311041
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Total 2022251810571
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Total 20241442966650
Jan 2025522070
Feb 2025618049
Mar 20251120160
Apr 2025415942
May 20251714854
Jun 202514813
Total 202544956288
Total2556192065559
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Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives
Clement Hamani, Gerson Florence, Helmut Heinsen, Birgit R. Plantinga, Yasin Temel, Kamil Uludag, Eduardo Alho, Manoel J. Teixeira, Edson Amaro, Erich T. Fonoff
eNeuro 13 September 2017, 4 (5) ENEURO.0140-17.2017; DOI: 10.1523/ENEURO.0140-17.2017

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Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives
Clement Hamani, Gerson Florence, Helmut Heinsen, Birgit R. Plantinga, Yasin Temel, Kamil Uludag, Eduardo Alho, Manoel J. Teixeira, Edson Amaro, Erich T. Fonoff
eNeuro 13 September 2017, 4 (5) ENEURO.0140-17.2017; DOI: 10.1523/ENEURO.0140-17.2017
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  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Anatomic aspects of the STN and nearby fiber structures
    • Fiber systems
    • Afferent and efferent STN projections
    • Physiologic properties of the STN and oscillatory activity
    • Behavioral effects of STN stimulation
    • Mechanisms of DBS
    • Cytoarchitectonic features and elements modulated by DBS
    • Neuroimaging
    • Conclusions
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • subthalamic nucleus
  • deep brain stimulation
  • Mechanisms
  • plasticity
  • anatomy
  • physiology
  • neuroimaging

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