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Research ArticleNew Research, Cognition and Behavior

Deep-Brain Stimulation of the Subthalamic Nucleus Selectively Decreases Risky Choice in Risk-Preferring Rats

Wendy K. Adams, Cole Vonder Haar, Melanie Tremblay, Paul J. Cocker, Mason M. Silveira, Sukhbir Kaur, Christelle Baunez and Catharine A. Winstanley
eNeuro 14 July 2017, 4 (4) ENEURO.0094-17.2017; https://doi.org/10.1523/ENEURO.0094-17.2017
Wendy K. Adams
1Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver V6T 1Z3, Canada
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  • ORCID record for Wendy K. Adams
Cole Vonder Haar
1Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver V6T 1Z3, Canada
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Melanie Tremblay
1Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver V6T 1Z3, Canada
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Paul J. Cocker
1Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver V6T 1Z3, Canada
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  • ORCID record for Paul J. Cocker
Mason M. Silveira
1Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver V6T 1Z3, Canada
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Sukhbir Kaur
1Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver V6T 1Z3, Canada
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Christelle Baunez
2Institut de Neurosciences de la Timone, UMR7289 Centre National de la Recherche Scientifique and Aix-Marseille Université, 13005, Marseille, France
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Catharine A. Winstanley
1Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver V6T 1Z3, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0094-17.2017
PubMed 
28791332
Published By 
Society for Neuroscience
History 
  • Received March 21, 2017
  • Revision received June 15, 2017
  • Accepted July 3, 2017
  • Published online July 14, 2017.
Copyright & Usage 
Copyright © 2017 Adams et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Wendy K. Adams1,*,
  2. Cole Vonder Haar1,*,
  3. Melanie Tremblay1,*,
  4. Paul J. Cocker1,
  5. Mason M. Silveira1,
  6. Sukhbir Kaur1,
  7. Christelle Baunez2 and
  8. Catharine A. Winstanley1
  1. 1Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver V6T 1Z3, Canada
  2. 2Institut de Neurosciences de la Timone, UMR7289 Centre National de la Recherche Scientifique and Aix-Marseille Université, 13005, Marseille, France
  1. Correspondence should be addressed to Catharine A. Winstanley, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. E-mail: cwinstanley{at}psych.ubc.ca.
  • C. V. Haar’s present address: Department of Psychology, West Virginia University, Morgantown, WV 26506.

  • Paul J. Cocker’s present address: Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom.

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Author contributions

  1. Author contributions: W.K.A., C.V.H., M.T., P.J.C., C.B., and C.A.W. designed research; W.K.A., C.V.H., M.T., P.J.C., M.M.S., and S.S.K. performed research; W.K.A., C.V.H., M.T., M.M.S., and C.A.W. analyzed data; C.B. and C.A.W. wrote the paper.

  2. ↵* W.K.A., C.V.H., and M.T. contributed equally to this work.

  • C. V. Haar’s present address: Department of Psychology, West Virginia University, Morgantown, WV 26506.

  • Paul J. Cocker’s present address: Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by an ERA-NET NEURON (TMD-110028) grant (to C.A.W. and C.B.). C.A.W. also received salary support through the Michael Smith Foundation for Health Research and the Canadian Institutes for Health Research (CIHR) New Investigator Award program. Over the past three years, C.A.W. has consulted for Shire and Hogan Lovells LLP and received due compensation. M.T. was supported by a Doctoral Research Award from CIHR. M.M.S. was supported by a Doctoral Research Award from the Canadian Natural Sciences and Engineering Research Council (NSERC). W.K.A. was supported by philanthropic funding provided by Paul and Diane Erickson and the Gillespie family. C.V.H. was supported by a CIHR postdoctoral fellowship.

Funding

  • ERA-NET

    TMD-110028
  • Michael Smith Foundation for Health Research (MSFHR)

    501100000245
  • Gouvernement du Canada | CIHR | Institute of Neurosciences, Mental Health and Addiction (INMHA)

    501100000034
  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

    501100000038

Other Version

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  • previous version (July 14, 2017).

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Aug 20173223017190
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Total1471130142188
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Deep-Brain Stimulation of the Subthalamic Nucleus Selectively Decreases Risky Choice in Risk-Preferring Rats
Wendy K. Adams, Cole Vonder Haar, Melanie Tremblay, Paul J. Cocker, Mason M. Silveira, Sukhbir Kaur, Christelle Baunez, Catharine A. Winstanley
eNeuro 14 July 2017, 4 (4) ENEURO.0094-17.2017; DOI: 10.1523/ENEURO.0094-17.2017

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Deep-Brain Stimulation of the Subthalamic Nucleus Selectively Decreases Risky Choice in Risk-Preferring Rats
Wendy K. Adams, Cole Vonder Haar, Melanie Tremblay, Paul J. Cocker, Mason M. Silveira, Sukhbir Kaur, Christelle Baunez, Catharine A. Winstanley
eNeuro 14 July 2017, 4 (4) ENEURO.0094-17.2017; DOI: 10.1523/ENEURO.0094-17.2017
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Keywords

  • addiction
  • basal ganglia
  • decision making
  • impulsivity
  • Parkinson’s disease
  • rat gambling task

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