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Research ArticleNew Research, Disorders of the Nervous System

Normal Striatal Vesicular Acetylcholine Transporter Expression in Tourette Syndrome

Roger L. Albin, Christine Minderovic and Robert A. Koeppe
eNeuro 27 July 2017, 4 (4) ENEURO.0178-17.2017; DOI: https://doi.org/10.1523/ENEURO.0178-17.2017
Roger L. Albin
1Neurology Service and Geriatrics Research, Education, and Clinical Center, Veterans Affairs Ann Arbor Health System, Ann Arbor, MI 48105
2Department of Neurology, University of Michigan, Ann Arbor, MI 48109
3University of Michigan Morris K. Udall Center, Ann Arbor, MI 41809
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Christine Minderovic
4Department of Radiology, University of Michigan, Ann Arbor, MI 48109
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Robert A. Koeppe
3University of Michigan Morris K. Udall Center, Ann Arbor, MI 41809
4Department of Radiology, University of Michigan, Ann Arbor, MI 48109
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    Figure 1. Striatal cholinergic terminal density measured by [18F]FEOBV PET in control (top row) and TS (bottom row) subjects. Averaged images from all subjects and images thresholded to optimize visualization of striatal [18F]FEOBV binding. No difference in striatal [18F]FEOBV binding between TS and NC subjects.

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    Table 2.

    Striatal [1 8F]FEOBV binding in TS and normal control subjects

    Mean caudate BP (SD)Mean putamen BP (SD)
    TS (N = 12)8.1016 (2.4500)9.2805 (2.7901)
    Normal control (N = 10)7.8982 (0.9475)9.1135 (1.0031)
    TS % difference from control102.6%101.8%
    p10.39740.4248
    • ↵1 Two-tailed t test.

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eneuro: 4 (4)
eNeuro
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Normal Striatal Vesicular Acetylcholine Transporter Expression in Tourette Syndrome
Roger L. Albin, Christine Minderovic, Robert A. Koeppe
eNeuro 27 July 2017, 4 (4) ENEURO.0178-17.2017; DOI: 10.1523/ENEURO.0178-17.2017

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Normal Striatal Vesicular Acetylcholine Transporter Expression in Tourette Syndrome
Roger L. Albin, Christine Minderovic, Robert A. Koeppe
eNeuro 27 July 2017, 4 (4) ENEURO.0178-17.2017; DOI: 10.1523/ENEURO.0178-17.2017
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Keywords

  • acetylcholine
  • striatum
  • Tourette Syndrome
  • VChAT

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