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Research ArticleNew Research, Disorders of the Nervous System

Targeted Interneuron Ablation in the Mouse Hippocampus Can Cause Spontaneous Recurrent Seizures

Jay Spampanato and F. Edward Dudek
eNeuro 12 July 2017, 4 (4) ENEURO.0130-17.2017; https://doi.org/10.1523/ENEURO.0130-17.2017
Jay Spampanato
Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT 84108
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F. Edward Dudek
Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT 84108
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0130-17.2017
PubMed 
28785726
Published By 
Society for Neuroscience
History 
  • Received April 13, 2017
  • Revision received June 30, 2017
  • Accepted July 11, 2017
  • Published online July 12, 2017.
Copyright & Usage 
Copyright © 2017 Spampanato and Dudek This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jay Spampanato and
  2. F. Edward Dudek
  1. Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT 84108
  1. Correspondence should be addressed to Jay Spampanato, Ph.D., Department of Neurosurgery, University of Utah School of Medicine, 383 Colorow Drive, Salt Lake City, UT 84108, E-mail: jay.spampanato{at}utah.edu.
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Author contributions

  1. Author contributions: J.S. and E.D. designed research; J.S. performed research; J.S. analyzed data; J.S. and E.D. wrote the paper.

Disclosures

  • F.E.D. has received financial support in the form of grants, gifts, and/or consulting fees from Neurona Therapeutics, Rugen Biomedical, and The Epilepsy Therapy Project, as well as grants and consulting fees from, and has equity interest in, Epitel, Inc., which manufactures and sells the Epoch recording devices used in the present studies. J.S. declares no competing financial interests.

  • This work was supported by the HHS NIH National Institute of Neurological Disorders and Stroke (NINDS) Grant NS079135.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    100000065; NS079135

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Total128192572894
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Targeted Interneuron Ablation in the Mouse Hippocampus Can Cause Spontaneous Recurrent Seizures
Jay Spampanato, F. Edward Dudek
eNeuro 12 July 2017, 4 (4) ENEURO.0130-17.2017; DOI: 10.1523/ENEURO.0130-17.2017

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Targeted Interneuron Ablation in the Mouse Hippocampus Can Cause Spontaneous Recurrent Seizures
Jay Spampanato, F. Edward Dudek
eNeuro 12 July 2017, 4 (4) ENEURO.0130-17.2017; DOI: 10.1523/ENEURO.0130-17.2017
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Keywords

  • CA1 Ablation
  • epilepsy
  • GABAergic
  • Local Field Potential
  • status epilepticus

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