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Research ArticleNew Research, Neuronal Excitability

A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2

Perrine Friedel, Anastasia Ludwig, Christophe Pellegrino, Morgane Agez, Anass Jawhari, Claudio Rivera and Igor Medina
eNeuro 12 July 2017, 4 (4) ENEURO.0055-17.2017; https://doi.org/10.1523/ENEURO.0055-17.2017
Perrine Friedel
1INMED, Aix-Marseille University, INSERM, Marseille 13273, France
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Anastasia Ludwig
2Neuroscience Center, University of Helsinki, Helsinki 00100, Finland
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Christophe Pellegrino
1INMED, Aix-Marseille University, INSERM, Marseille 13273, France
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  • ORCID record for Christophe Pellegrino
Morgane Agez
3CALIXAR, Lyon 69008, France
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Anass Jawhari
3CALIXAR, Lyon 69008, France
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Claudio Rivera
1INMED, Aix-Marseille University, INSERM, Marseille 13273, France
2Neuroscience Center, University of Helsinki, Helsinki 00100, Finland
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Igor Medina
1INMED, Aix-Marseille University, INSERM, Marseille 13273, France
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0055-17.2017
PubMed 
28785725
Published By 
Society for Neuroscience
History 
  • Received February 15, 2017
  • Revision received June 20, 2017
  • Accepted July 4, 2017
  • Published online July 12, 2017.
Copyright & Usage 
Copyright © 2017 Friedel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Perrine Friedel1,
  2. Anastasia Ludwig2,
  3. Christophe Pellegrino1,
  4. Morgane Agez3,
  5. Anass Jawhari3,
  6. Claudio Rivera1,2 and
  7. Igor Medina1
  1. 1INMED, Aix-Marseille University, INSERM, Marseille 13273, France
  2. 2Neuroscience Center, University of Helsinki, Helsinki 00100, Finland
  3. 3CALIXAR, Lyon 69008, France
  1. Correspondence should be addressed to Igor Medina, INMED/INSERM Unité 901, 163 Route de Luminy, 13273 Marseille, France. E-mail: igor.medyna{at}inserm.fr.
  • Perrine Friedel’s current address is Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510. Anastasia Ludwig’s current address is École Normale Supérieure, Institut De Biologie De l’ENS (IBENS), Inserm U1024, CNRS 8197, Biologie Cellulaire De La Synapse, 46 Rue D’Ulm, Paris 75005, France.

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Author contributions

  1. Author contributions: conceptualization, P.F. and I.M.; methodology and experimental design, P.F., A.L., C.P., M.A., A.J., C.R., and I.M.; investigation, P.F., A.L., C.P., M.A., A.J., and I.M.; writing, P.F., A.L., A.J., and I.M.; funding acquisition, C.R. and I.M.; supervision, C.R. and I.M.; project administration, I.M.

  • Perrine Friedel’s current address is Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510. Anastasia Ludwig’s current address is École Normale Supérieure, Institut De Biologie De l’ENS (IBENS), Inserm U1024, CNRS 8197, Biologie Cellulaire De La Synapse, 46 Rue D’Ulm, Paris 75005, France.

Disclosures

  • The authors declare that they have no conflicts of interest.

  • This work was supported by the Institut National de la Santé et de la Recherche Médicale (INSERM; I.M. and C.R.), Aix-Marseille University (AMU; I.M. and C.R.), University of Helsinki (C.R.), the Agence Nationale de la Recherche (ANR; TRAUMEP ANR 13-BSV4-0012-01; C.R. and I.M.), and Academy of Finland (SA 259799; C.R.). P.F. was supported by an INSERM-CR-PACA-FEDER grant, and A.L. was supported by the Academy of Finland (SA 250742).

Funding

  • Arthritis National Research Foundation (ANRF)

    100000964; TRAUMEP ANR 13-BSV4-0012-01
  • Academy of Finland | Biotieteiden ja Ympäristön Tutkimuksen Toimikunta (Forskningsrådet för Biovetenskap och Miljö)

    501100005876; SA 259799
  • Institut National de la Santé et de la Recherche Médicale (Inserm)

    501100001677; INSERM-CR-PACA-FEDER

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  • previous version (July 12, 2017).
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Aug 2017460167125
Sep 2017969261
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Total 202040417126
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Jul 202135014
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Total 202127650185
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Total 2025671067278
Jan 20261012014
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Mar 20261713944
Apr 20262016946
May 202612518
Total 202654622136
Total115562811968
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A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2
Perrine Friedel, Anastasia Ludwig, Christophe Pellegrino, Morgane Agez, Anass Jawhari, Claudio Rivera, Igor Medina
eNeuro 12 July 2017, 4 (4) ENEURO.0055-17.2017; DOI: 10.1523/ENEURO.0055-17.2017

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A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2
Perrine Friedel, Anastasia Ludwig, Christophe Pellegrino, Morgane Agez, Anass Jawhari, Claudio Rivera, Igor Medina
eNeuro 12 July 2017, 4 (4) ENEURO.0055-17.2017; DOI: 10.1523/ENEURO.0055-17.2017
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Keywords

  • chloride
  • GABA
  • KCC2

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