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Research ArticleNew Research, Neuronal Excitability

Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior

Tracey O. Hermanstyne, Daniel Granados-Fuentes, Rebecca L. Mellor, Erik D. Herzog and Jeanne M. Nerbonne
eNeuro 12 May 2017, 4 (3) ENEURO.0377-16.2017; https://doi.org/10.1523/ENEURO.0377-16.2017
Tracey O. Hermanstyne
1Departments of Developmental Biology and Internal Medicine Washington University School of Medicine, Washington University, St. Louis, MO 63130
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Daniel Granados-Fuentes
2Department of Biology, Washington University, St. Louis, MO 63130
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Rebecca L. Mellor
1Departments of Developmental Biology and Internal Medicine Washington University School of Medicine, Washington University, St. Louis, MO 63130
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Erik D. Herzog
2Department of Biology, Washington University, St. Louis, MO 63130
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Jeanne M. Nerbonne
1Departments of Developmental Biology and Internal Medicine Washington University School of Medicine, Washington University, St. Louis, MO 63130
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0377-16.2017
PubMed 
28560311
Published By 
Society for Neuroscience
History 
  • Received December 19, 2016
  • Revision received April 14, 2017
  • Accepted May 7, 2017
  • Published online May 12, 2017.
Copyright & Usage 
Copyright © 2017 Hermanstyne et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Tracey O. Hermanstyne1,*,
  2. Daniel Granados-Fuentes2,*,
  3. Rebecca L. Mellor1,
  4. Erik D. Herzog2 and
  5. Jeanne M. Nerbonne1,*
  1. 1Departments of Developmental Biology and Internal Medicine Washington University School of Medicine, Washington University, St. Louis, MO 63130
  2. 2Department of Biology, Washington University, St. Louis, MO 63130
  1. Correspondence should be addressed to Jeanne M. Nerbonne, Department of Medicine, Cardiovascular Division, Washington University School of Medicine, Box 8086, 660 South Euclid Avenue, St. Louis, MO 63110, E-mail: jnerbonne{at}wustl.edu.
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Author contributions

  1. Author contributions: T.O.H., D.G.-F., E.D.H., and J.M.N. designed research; T.O.H., D.G.-F., and R.L.M. performed research; T.O.H. and D.G.-F. analyzed data; T.O.H., D.G.-F., E.D.H., and J.M.N. wrote the paper.

  2. ↵* T.O.H. and D.G.-F. contributed equally.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institute of General Medical Sciences Grant R01 GM104991 (to E.D.H. and J.M.N.) and by a UNCF/Merck Postdoctoral Fellowship to T.O.H.

Funding

  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    100000057; GM104991
  • United Negro College Fund Special Programs Corporation (UNCFSP)

    100000848

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  • You are viewing the most recent version of this article.
  • previous version (May 12, 2017).

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Total63451891538
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Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior
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Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior
Tracey O. Hermanstyne, Daniel Granados-Fuentes, Rebecca L. Mellor, Erik D. Herzog, Jeanne M. Nerbonne
eNeuro 12 May 2017, 4 (3) ENEURO.0377-16.2017; DOI: 10.1523/ENEURO.0377-16.2017

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Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior
Tracey O. Hermanstyne, Daniel Granados-Fuentes, Rebecca L. Mellor, Erik D. Herzog, Jeanne M. Nerbonne
eNeuro 12 May 2017, 4 (3) ENEURO.0377-16.2017; DOI: 10.1523/ENEURO.0377-16.2017
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Keywords

  • a-Type Current
  • Action Potential Waveforms
  • Kv Channels
  • Period2
  • Repetitive Firing Properties
  • SCN

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