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PreviousNext
Research ArticleNew Research, Cognition and Behavior

Loss of the Habenula Intrinsic Neuromodulator Kisspeptin1 Affects Learning in Larval Zebrafish

Charlotte Lupton, Mohini Sengupta, Ruey-Kuang Cheng, Joanne Chia, Vatsala Thirumalai and Suresh Jesuthasan
eNeuro 8 May 2017, 4 (3) ENEURO.0326-16.2017; https://doi.org/10.1523/ENEURO.0326-16.2017
Charlotte Lupton
1Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK
2Institute for Molecular and Cell Biology, 138673, Singapore
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Mohini Sengupta
3National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, 560065, India
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Ruey-Kuang Cheng
4Lee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore
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Joanne Chia
5National University of Singapore Graduate School for Integrative Sciences and Engineering, 117456, Singapore
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Vatsala Thirumalai
3National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, 560065, India
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Suresh Jesuthasan
2Institute for Molecular and Cell Biology, 138673, Singapore
4Lee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore
6Duke-NUS Graduate Medical School, 169857 Singapore
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0326-16.2017
PubMed 
28534042
Published By 
Society for Neuroscience
History 
  • Received October 25, 2016
  • Revision received March 14, 2017
  • Accepted March 30, 2017
  • Published online May 8, 2017.
Copyright & Usage 
Copyright © 2017 Lupton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Charlotte Lupton1,2,*,
  2. Mohini Sengupta3,*,
  3. Ruey-Kuang Cheng4,*,
  4. Joanne Chia5,
  5. Vatsala Thirumalai3,* and
  6. Suresh Jesuthasan2,4,6
  1. 1Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK
  2. 2Institute for Molecular and Cell Biology, 138673, Singapore
  3. 3National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, 560065, India
  4. 4Lee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore
  5. 5National University of Singapore Graduate School for Integrative Sciences and Engineering, 117456, Singapore
  6. 6Duke-NUS Graduate Medical School, 169857 Singapore
  1. Correspondence should be addressed to either of the following: Suresh Jesuthasan. E-mail: sureshj{at}ntu.edu.sg; or Vatsala Thirumalai. E-mail: vatsala{at}ncbs.res.in.
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Author contributions

  1. Author contributions: CL, MS, RKC, VT, and SJ designed research; CL, MS, and RKC performed research; CL, MS, RKC, JC, and VT analyzed data; SJ wrote the paper.

  2. ↵* C. Lupton, M. Sengupta, and R.-K. Cheng contributed equally to this work and should be considered joint first authors.

Disclosures

  • Authors report no conflict of interest.

  • CL was funded by the A*Star Graduate Academy, under the ARAP scheme. MS was supported by Senior Research Fellowship from Council of Scientific and Industrial Research. JC was funded by the National University of Singapore Graduate School. This work was supported by core funding from Institute for Molecular and Cell Biology and a Lee Kong Chian School of Medicine, Nanyang Technological University MOE Start-Up Grant to SJ; core funding from National Centre for Biological Sciences; Intermediate Fellowship from Wellcome Trust-DBT India Alliance; and grant funding from the Department of Biotechnology to VT.

Funding

  • Agency for Science, Technology and Research (A*STAR)

    501100001348
  • Ministry of Education - Singapore (MOE)

    501100001459
  • Department of Biotechnology, India

  • Welcome Trust - DBT India Alliance

  • Council of Scientific and Industrial Research (CSIR)

    501100001412

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 08, 2017).

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Loss of the Habenula Intrinsic Neuromodulator Kisspeptin1 Affects Learning in Larval Zebrafish
Charlotte Lupton, Mohini Sengupta, Ruey-Kuang Cheng, Joanne Chia, Vatsala Thirumalai, Suresh Jesuthasan
eNeuro 8 May 2017, 4 (3) ENEURO.0326-16.2017; DOI: 10.1523/ENEURO.0326-16.2017

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Loss of the Habenula Intrinsic Neuromodulator Kisspeptin1 Affects Learning in Larval Zebrafish
Charlotte Lupton, Mohini Sengupta, Ruey-Kuang Cheng, Joanne Chia, Vatsala Thirumalai, Suresh Jesuthasan
eNeuro 8 May 2017, 4 (3) ENEURO.0326-16.2017; DOI: 10.1523/ENEURO.0326-16.2017
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Keywords

  • calcium imaging
  • electrophysiology
  • habenula
  • Intrinsic Neuromodulation
  • mutant
  • operant learning

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