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History
- Received October 20, 2016
- Revision received June 8, 2017
- Accepted June 9, 2017
- Published online June 19, 2017.
Copyright & Usage
Copyright © 2017 Middleton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Author Information
- Jason W. Middleton1,
- Daniel J. Simons2,
- Jennifer W. Simmons3,
- Robert S.B. Clark4,5,
- Patrick M. Kochanek4,5 and
- Michael Shoykhet3
- 1Department of Cell Biology and Anatomy, Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112
- 2Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
- 3Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO 63110
- 4Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
- 5Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15260
- Correspondence should be addressed to either of the following: Michael Shoykhet, MD, PhD, Division of Pediatric Critical Care Medicine, Department of Pediatrics, Washington University in St. Louis School of Medicine, Box 8208, 660 S. Euclid Ave, St. Louis, MO 63110. E-mail: Shoykhet_m{at}wustl.edu; or Jason W. Middleton, PhD, Department of Cell Biology and Anatomy, Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112. E-mail: jmidd3{at}lsuhsc.edu.
Author contributions
Author contributions: JWM, DJS, RSBC, PMK, and MS designed research. JWM, JWS, and MS performed research and analyzed data. JWM, DJS, RSBC, PMK, and MS wrote the paper.
Disclosures
Authors report no conflict of interest.
This study was supported by NIH Grants K08 NS-082362 (to M.S.), NS19950 (to D.J.S.), and HD045968 (to R.S.B.C.). M.S. was also supported by the Pediatric Critical Care Scientist Development Program (5K12-HD04739-8, University of Utah), Children’s Discovery Institute of the St. Louis Children’s Hospital, McDonnell Center for Systems Neuroscience, and Child Health Research Center of Excellence in Developmental Biology at Washington University School of Medicine (K12-HD01487).
Funding
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
100000065; K08 NS082362HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
100000065; NS19550HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
100009633; HD045968HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
100009633; 5K12 HD04739-8HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
100009633; K12 HD 01487Children's Discovery Institute (CDI)
100009340; FR-2011-145WUSTL | McDonnell Center for Systems Neuroscience
100009607
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