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Research ArticleNew Research, Sensory and Motor Systems

Optogenetic Evidence for a Direct Circuit Linking Nociceptive Transmission through the Parabrachial Complex with Pain-Modulating Neurons of the Rostral Ventromedial Medulla (RVM)

QiLiang Chen, Zachary Roeder, Ming-Hua Li, YangMiao Zhang, Susan L. Ingram and Mary M. Heinricher
eNeuro 19 June 2017, 4 (3) ENEURO.0202-17.2017; https://doi.org/10.1523/ENEURO.0202-17.2017
QiLiang Chen
1Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239
3Neuroscience Graduate Program, Oregon Health & Science University, Portland, OR 97239
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Zachary Roeder
1Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239
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Ming-Hua Li
1Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239
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YangMiao Zhang
1Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239
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Susan L. Ingram
1Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239
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Mary M. Heinricher
1Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239
2Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0202-17.2017
PubMed 
28660248
Published By 
Society for Neuroscience
History 
  • Received June 8, 2017
  • Accepted June 9, 2017
  • Published online June 19, 2017.
Copyright & Usage 
Copyright © 2017 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. QiLiang Chen1,3,
  2. Zachary Roeder1,
  3. Ming-Hua Li1,
  4. YangMiao Zhang1,
  5. Susan L. Ingram1 and
  6. Mary M. Heinricher1,2
  1. 1Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239
  2. 2Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239
  3. 3Neuroscience Graduate Program, Oregon Health & Science University, Portland, OR 97239
  1. Correspondence should be addressed to Mary M. Heinricher, Oregon Health and Science University, Department of Neurological Surgery, L-472, 3181 SW Sam Jackson Park Road, Portland, OR 97239, E-mail: heinricm{at}ohsu.edu.
View Full Text

Author contributions

  1. Author contributions: Q.C., Z.R., Y.Z., S.L.I., and M.M.H. designed research; Q.C., Z.R., Y.Z., and M.-H.L. performed research; Q.C., Z.R., Y.Z., and M.-H.L. analyzed data; Q.C., Z.R., Y.Z., S.L.I., and M.M.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by NIH Grants NS066159 and NS093894. Q.C. was supported by NIH Grant F31 NS087634.

Funding

  • NIH

    NS066159
  • NIH

    NS093894
  • NIH

    F31 NS087634

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Jun 2017022
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Total 2024831077256
Jan 202577131
Feb 2025510117
Mar 202528025
Apr 202525616
May 202535915
Jun 20257558
Jul 20256439
Total 202532465121
Total153781612108
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Optogenetic Evidence for a Direct Circuit Linking Nociceptive Transmission through the Parabrachial Complex with Pain-Modulating Neurons of the Rostral Ventromedial Medulla (RVM)
QiLiang Chen, Zachary Roeder, Ming-Hua Li, YangMiao Zhang, Susan L. Ingram, Mary M. Heinricher
eNeuro 19 June 2017, 4 (3) ENEURO.0202-17.2017; DOI: 10.1523/ENEURO.0202-17.2017

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Optogenetic Evidence for a Direct Circuit Linking Nociceptive Transmission through the Parabrachial Complex with Pain-Modulating Neurons of the Rostral Ventromedial Medulla (RVM)
QiLiang Chen, Zachary Roeder, Ming-Hua Li, YangMiao Zhang, Susan L. Ingram, Mary M. Heinricher
eNeuro 19 June 2017, 4 (3) ENEURO.0202-17.2017; DOI: 10.1523/ENEURO.0202-17.2017
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Keywords

  • brainstem
  • Descending Control
  • pain modulation
  • raphe
  • rat

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