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Research ArticleNew Research, Disorders of the Nervous System

A Brain-Derived Neurotrophic Factor-Based p75NTR Peptide Mimetic Ameliorates Experimental Autoimmune Neuritis Induced Axonal Pathology and Demyelination

David G. Gonsalvez, Giang Tran, Jessica L. Fletcher, Richard A. Hughes, Suzanne Hodgkinson, Rhiannon J. Wood, Sang Won Yoo, Mithraka De Silva, Wong W. Agnes, Catriona McLean, Paul Kennedy, Trevor J. Kilpatrick, Simon S. Murray and Junhua Xiao
eNeuro 28 June 2017, 4 (3) ENEURO.0142-17.2017; https://doi.org/10.1523/ENEURO.0142-17.2017
David G. Gonsalvez
1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
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Giang Tran
3Liverpool Hospital, The University of New South Wales, NSW 2170, Australia
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Jessica L. Fletcher
1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
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Richard A. Hughes
2Department of Pharmacology and Therapeutics, The University of Melbourne, VIC 3010, Australia
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Suzanne Hodgkinson
3Liverpool Hospital, The University of New South Wales, NSW 2170, Australia
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Rhiannon J. Wood
1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
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Sang Won Yoo
1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
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Mithraka De Silva
1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
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Wong W. Agnes
1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
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Catriona McLean
4Victorian Neuromuscular Laboratory Services, Alfred Health, VIC 3004, Australia
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Paul Kennedy
4Victorian Neuromuscular Laboratory Services, Alfred Health, VIC 3004, Australia
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Trevor J. Kilpatrick
1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
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Simon S. Murray
1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
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Junhua Xiao
1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0142-17.2017
PubMed 
28680965
Published By 
Society for Neuroscience
History 
  • Received April 24, 2017
  • Revision received June 15, 2017
  • Accepted June 19, 2017
  • Published online June 28, 2017.
Copyright & Usage 
Copyright © 2017 Gonsalvez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. David G. Gonsalvez1,
  2. Giang Tran3,
  3. Jessica L. Fletcher1,
  4. Richard A. Hughes2,
  5. Suzanne Hodgkinson3,
  6. Rhiannon J. Wood1,
  7. Sang Won Yoo1,
  8. Mithraka De Silva1,
  9. Wong W. Agnes1,
  10. Catriona McLean4,
  11. Paul Kennedy4,
  12. Trevor J. Kilpatrick1,
  13. Simon S. Murray1 and
  14. Junhua Xiao1
  1. 1Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia
  2. 2Department of Pharmacology and Therapeutics, The University of Melbourne, VIC 3010, Australia
  3. 3Liverpool Hospital, The University of New South Wales, NSW 2170, Australia
  4. 4Victorian Neuromuscular Laboratory Services, Alfred Health, VIC 3004, Australia
  1. Correspondence should be addressed to Junhua Xiao, Department of Anatomy and Neuroscience, The University of Melbourne, VIC 3010, Australia, E-mail: xiaoj{at}unimelb.edu.au.
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Author contributions

  1. Author contributions: D.G.G., R.H., S.S.M., and J.X. designed research; D.G.G., G.T., J.L.F., R.J.W., S.Y., M.D.S., W.W.A., P.K., and J.X. performed research; C.M. and P.K. contributed unpublished reagents/analytic tools; D.G.G., G.T., J.L.F., R.H., S.H., R.J.W., S.Y., M.D.S., W.W.A., T.J.K., S.S.M., and J.X. analyzed data; D.G.G., R.H., T.J.K., S.S.M., and J.X. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Australian National Health and Medical Research Council Project Grant APP1058647 (to X.J.), The University of Melbourne Research Grant Support Scheme, and Melbourne Research Career Interruption Fellowship (X.J.).

Funding

  • Department of Health | National Health and Medical Research Council (NHMRC)

    501100000925; APP1058647

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  • You are viewing the most recent version of this article.
  • previous version (June 28, 2017).

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Jul 2017254849
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Sep 2017575541
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Total 2017363339324
Jan 2018133526
Feb 2018263421
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Apr 2018119923
May 20181528914
Jun 20182528123
Jul 2018128817
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Total 20181741416255
Jan 2019513512
Feb 2019716112
Mar 201942247
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Oct 2019329017
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Jan 20205236
Feb 202022823
Mar 2020398
May 202033927
Jun 20201677
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Total 202050474162
Jan 202104312
Feb 20210357
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Apr 20214606
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Jul 2025106424
Aug 202555226
Sep 202599613
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Total 202574807231
Jan 20261613749
Feb 2026814931
Mar 202632847
Total 202627314127
Total84277691831
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A Brain-Derived Neurotrophic Factor-Based p75NTR Peptide Mimetic Ameliorates Experimental Autoimmune Neuritis Induced Axonal Pathology and Demyelination
David G. Gonsalvez, Giang Tran, Jessica L. Fletcher, Richard A. Hughes, Suzanne Hodgkinson, Rhiannon J. Wood, Sang Won Yoo, Mithraka De Silva, Wong W. Agnes, Catriona McLean, Paul Kennedy, Trevor J. Kilpatrick, Simon S. Murray, Junhua Xiao
eNeuro 28 June 2017, 4 (3) ENEURO.0142-17.2017; DOI: 10.1523/ENEURO.0142-17.2017

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A Brain-Derived Neurotrophic Factor-Based p75NTR Peptide Mimetic Ameliorates Experimental Autoimmune Neuritis Induced Axonal Pathology and Demyelination
David G. Gonsalvez, Giang Tran, Jessica L. Fletcher, Richard A. Hughes, Suzanne Hodgkinson, Rhiannon J. Wood, Sang Won Yoo, Mithraka De Silva, Wong W. Agnes, Catriona McLean, Paul Kennedy, Trevor J. Kilpatrick, Simon S. Murray, Junhua Xiao
eNeuro 28 June 2017, 4 (3) ENEURO.0142-17.2017; DOI: 10.1523/ENEURO.0142-17.2017
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Keywords

  • axonal damage
  • BDNF
  • demyelination
  • Experimental Autoimmune Neuritis
  • p75NTR

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