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Research ArticleNew Research, Sensory and Motor Systems

Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment

Kayla Lemons, Ziying Fu, Imad Aoudé, Tatsuya Ogura, Julianna Sun, Justin Chang, Kenechukwu Mbonu, Ichiro Matsumoto, Hiroyuki Arakawa and Weihong Lin
eNeuro 5 June 2017, 4 (3) ENEURO.0135-17.2017; https://doi.org/10.1523/ENEURO.0135-17.2017
Kayla Lemons
1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD
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Ziying Fu
1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD
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Imad Aoudé
1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD
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Tatsuya Ogura
1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD
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Julianna Sun
1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD
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Justin Chang
1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD
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Kenechukwu Mbonu
1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD
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Ichiro Matsumoto
2Monell Chemical Senses Center, Philadelphia, PA
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Hiroyuki Arakawa
3Department of Research Administration, School of Medicine, Case Western Reserve University, Cleveland, OH
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Weihong Lin
1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0135-17.2017
PubMed 
28612045
Published By 
Society for Neuroscience
History 
  • Received April 19, 2017
  • Revision received May 18, 2017
  • Accepted May 29, 2017
  • Published online June 5, 2017.
Copyright & Usage 
Copyright © 2017 Lemons et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kayla Lemons1,*,
  2. Ziying Fu1,*,
  3. Imad Aoudé1,*,
  4. Tatsuya Ogura1,*,
  5. Julianna Sun1,
  6. Justin Chang1,
  7. Kenechukwu Mbonu1,
  8. Ichiro Matsumoto2,
  9. Hiroyuki Arakawa3 and
  10. Weihong Lin1
  1. 1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD
  2. 2Monell Chemical Senses Center, Philadelphia, PA
  3. 3Department of Research Administration, School of Medicine, Case Western Reserve University, Cleveland, OH
  1. Correspondence should be addressed to Weihong Lin, PhD, Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD 21250. E-mail: weihong{at}umbc.edu.
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Author contributions

  1. Author contributions: KL, ZF, IA, TO, JS, JC, and KM performed experiments. KL, ZF, TO, JC, IM, and HA performed data analysis and participated in drafting the manuscript. WL conceived and supervised the project and drafted most of the manuscript. All authors read, edited and approved the manuscript.

  2. ↵* K.L., Z.F., I.A., and T.O. contributed equally to this work.

Disclosures

  • The authors report no conflict of interests.

  • This work was supported by NIH/NIDCD DC012831 to Weihong Lin.

Funding

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    100000055; DC012831

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  • You are viewing the most recent version of this article.
  • previous version (June 05, 2017).

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Total62464491494
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Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment
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Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment
Kayla Lemons, Ziying Fu, Imad Aoudé, Tatsuya Ogura, Julianna Sun, Justin Chang, Kenechukwu Mbonu, Ichiro Matsumoto, Hiroyuki Arakawa, Weihong Lin
eNeuro 5 June 2017, 4 (3) ENEURO.0135-17.2017; DOI: 10.1523/ENEURO.0135-17.2017

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Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment
Kayla Lemons, Ziying Fu, Imad Aoudé, Tatsuya Ogura, Julianna Sun, Justin Chang, Kenechukwu Mbonu, Ichiro Matsumoto, Hiroyuki Arakawa, Weihong Lin
eNeuro 5 June 2017, 4 (3) ENEURO.0135-17.2017; DOI: 10.1523/ENEURO.0135-17.2017
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Keywords

  • Olfactory Behaviors
  • olfactory epithelium
  • Olfactory Responses
  • TRPM5
  • TRPM5-Expressing Microvillous Cells

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