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Research ArticleNew Research, Development

Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry

Marta Pratelli, Sara Migliarini, Barbara Pelosi, Francesco Napolitano, Alessandro Usiello and Massimo Pasqualetti
eNeuro 3 April 2017, 4 (2) ENEURO.0376-16.2017; https://doi.org/10.1523/ENEURO.0376-16.2017
Marta Pratelli
1Department of Biology Unit of Cell and Developmental Biology, University of Pisa, Pisa 56127, Italy
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Sara Migliarini
1Department of Biology Unit of Cell and Developmental Biology, University of Pisa, Pisa 56127, Italy
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Barbara Pelosi
1Department of Biology Unit of Cell and Developmental Biology, University of Pisa, Pisa 56127, Italy
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Francesco Napolitano
2Ceinge Biotecnologie Avanzate, Naples 80145, Italy
3Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
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Alessandro Usiello
2Ceinge Biotecnologie Avanzate, Naples 80145, Italy
4Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania, Luigi Vanvitelli, Italy
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Massimo Pasqualetti
1Department of Biology Unit of Cell and Developmental Biology, University of Pisa, Pisa 56127, Italy
5Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, TN 38068, Italy
6Neuroscience Institute, National Research Council (CNR), Pisa 56124, Italy
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  • RE: Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
    Maya Frankfurt
    Submitted on: 17 April 2017
  • Submitted on: (17 April 2017)
    Page navigation anchor for RE: Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
    RE: Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
    • Maya Frankfurt, Professor, Hofstra Northwell School of Medicine

    In the discussion the authors state that the ability of adult serotonergic axons to undergo active sprouting has been described solely in response to physical lesions of brain . In fact this overlooks a series of studies that examined the regeneration of serotonin fibers in adult rat dorsomedial hypothalamus following the neurotoxin 5,7-DHT at the LM (Frankfurt and Azmitia 1983 ) and EM level (Frankfurt and Beaudet, 1987, 1988). Regardless of whether the authors may be referring to collateral sprouting of intact fibers rather than regeneration it seems relevant.

    Competing Interests: None declared.
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eneuro: 4 (2)
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March/April 2017
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Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
Marta Pratelli, Sara Migliarini, Barbara Pelosi, Francesco Napolitano, Alessandro Usiello, Massimo Pasqualetti
eNeuro 3 April 2017, 4 (2) ENEURO.0376-16.2017; DOI: 10.1523/ENEURO.0376-16.2017

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Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
Marta Pratelli, Sara Migliarini, Barbara Pelosi, Francesco Napolitano, Alessandro Usiello, Massimo Pasqualetti
eNeuro 3 April 2017, 4 (2) ENEURO.0376-16.2017; DOI: 10.1523/ENEURO.0376-16.2017
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Keywords

  • 5-Hydroxytryptophan
  • Serotonergic Innervations
  • serotonin
  • Serotonin Homeostasis
  • tryptophan hydroxylase 2

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Jump to comment:

  • RE: Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
    Maya Frankfurt
    Published on: 17 April 2017
  • Published on: (17 April 2017)
    Page navigation anchor for RE: Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
    RE: Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
    • Maya Frankfurt, Professor, Hofstra Northwell School of Medicine

    In the discussion the authors state that the ability of adult serotonergic axons to undergo active sprouting has been described solely in response to physical lesions of brain . In fact this overlooks a series of studies that examined the regeneration of serotonin fibers in adult rat dorsomedial hypothalamus following the neurotoxin 5,7-DHT at the LM (Frankfurt and Azmitia 1983 ) and EM level (Frankfurt and Beaudet, 1987, 1988). Regardless of whether the authors may be referring to collateral sprouting of intact fibers rather than regeneration it seems relevant.

    Competing Interests: None declared.

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