Early Social Isolation Stress and Perinatal NMDA Receptor Antagonist Treatment Induce Changes in the Structure and Neurochemistry of Inhibitory Neurons of the Adult Amygdala and Prefrontal Cortex

Author contributions: E.C.-G. and J.N. designed the study; E.C.-.G., M.P.-R., M.B., J.G.-J., J.V.L., H.C., C.B.-F., C.G.-M., B.R.-M., Y.C., and N.S.-O. performed the experiments; E.C.-G. and M.P.-R. analyzed the data; E.C.-G. and M.P.-R. prepared the figures; E.C.-G., M.P.-R., and J.N. wrote the paper; M.D.M. supervised the molecular part of the project; J.S. reviewed the manuscript and gave clinical advice. J.N. supervised the whole project; all authors read and approved the final paper.

F and p values: (98) F_(1,19) = 11.74, p = 0.003; (99) F_(1,25) = 11.58, p = 0.002; (100) F_(1,25) = 107.23, p < 10⁻¹⁰; (101) F_(1,25) = 4.02, p = 0.056; (102) F_(1,32) = 9.863, p = 0.004; (103) F_(1,25) = 3.94, p = 0.058; (104) F_(1,26) = 13.51, p = 0.001; (105) F_(1,25) = 4.10, p = 0.054; (106) F_(1,26) = 5.52, p = 0.027; (107) F_(1,20) = 3.07, p = 0.095; (108) F_(1,25) = 4.12, p = 0.053; (109) F_(1,25) = 5.06, p = 0.033.