Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry

In the discussion the authors state that the ability of adult serotonergic axons to undergo active sprouting has been described solely in response to physical lesions of brain . In fact this overlooks a series of studies that examined the regeneration of serotonin fibers in adult rat dorsomedial hypothalamus following the neurotoxin 5,7-DHT at the LM (Frankfurt and Azmitia 1983 ) and EM level (Frankfurt and Beaudet, 1987, 1988). Regardless of whether the authors may be referring to collateral sprouting of intact fibers rather than regeneration it seems relevant.