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Research ArticleNew Research, Cognition and Behavior

Adaptive Value Normalization in the Prefrontal Cortex Is Reduced by Memory Load

L. Holper, L. D. Van Brussel, L. Schmidt, S. Schulthess, C. J. Burke, K. Louie, E. Seifritz and P. N. Tobler
eNeuro 18 April 2017, 4 (2) ENEURO.0365-17.2017; https://doi.org/10.1523/ENEURO.0365-17.2017
L. Holper
1Department of Psychiatry Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland
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  • ORCID record for L. Holper
L. D. Van Brussel
2Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, 8006 Zurich, Switzerland
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L. Schmidt
1Department of Psychiatry Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland
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S. Schulthess
1Department of Psychiatry Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland
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C. J. Burke
2Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, 8006 Zurich, Switzerland
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K. Louie
3Center for Neural Science, New York University, New York, NY 10003
4Institute for the Interdisciplinary Study of Decision Making, New York University, Brooklyn, NY 11201
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E. Seifritz
1Department of Psychiatry Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland
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P. N. Tobler
2Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, 8006 Zurich, Switzerland
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0365-17.2017
PubMed 
28462394
Published By 
Society for Neuroscience
History 
  • Received December 11, 2016
  • Revision received March 30, 2017
  • Accepted April 4, 2017
  • Published online April 18, 2017.
Copyright & Usage 
Copyright © 2017 Holper et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. L. Holper1,
  2. L. D. Van Brussel2,
  3. L. Schmidt1,
  4. S. Schulthess1,
  5. C. J. Burke2,
  6. K. Louie3,4,
  7. E. Seifritz1 and
  8. P. N. Tobler2
  1. 1Department of Psychiatry Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland
  2. 2Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, 8006 Zurich, Switzerland
  3. 3Center for Neural Science, New York University, New York, NY 10003
  4. 4Institute for the Interdisciplinary Study of Decision Making, New York University, Brooklyn, NY 11201
  1. Correspondence should be addressed to Lisa Holper, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, CH-8032 Zurich, Switzerland. E-mail: lisa.holper{at}puk.zh.ch.
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Author contributions

  1. Author contributions: LH, LDVB, CJB, and PNT designed the project; LDVB, LS, and SS performed research; LH analyzed data; LH, LDVB, KL, ES, and PNT wrote the paper.

Disclosures

  • The authors report no conflict of interest.

  • This work was funded by the academic career program Filling the Gap (grant number FTG-1415-007) of the University of Zurich and by the Swiss National Science Foundation (grant numbers PP00P1_150739 and 00014_165884).

Funding

  • Filling the gap

    FTG-1415-007
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF)

    501100001711; PP00P1_150739
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF)

    501100001711; 00014_165884

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 18, 2017).

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Adaptive Value Normalization in the Prefrontal Cortex Is Reduced by Memory Load
L. Holper, L. D. Van Brussel, L. Schmidt, S. Schulthess, C. J. Burke, K. Louie, E. Seifritz, P. N. Tobler
eNeuro 18 April 2017, 4 (2) ENEURO.0365-17.2017; DOI: 10.1523/ENEURO.0365-17.2017

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Adaptive Value Normalization in the Prefrontal Cortex Is Reduced by Memory Load
L. Holper, L. D. Van Brussel, L. Schmidt, S. Schulthess, C. J. Burke, K. Louie, E. Seifritz, P. N. Tobler
eNeuro 18 April 2017, 4 (2) ENEURO.0365-17.2017; DOI: 10.1523/ENEURO.0365-17.2017
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Keywords

  • adaptive coding
  • value normalization
  • Risky Decision-Making
  • memory load
  • prefrontal cortex
  • computational model comparison
  • functional near-infrared spectroscopy

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