Article Information
- Received August 22, 2016
- Revision received March 6, 2017
- Accepted March 7, 2017
- Published online March 28, 2017.
Author Information
- Ikuo Tomioka1,
- Hidetoshi Ishibashi1,
- Eiko N. Minakawa2,
- Hideyuki H. Motohashi1,
- Osamu Takayama1,
- Yuko Saito3,
- H. Akiko Popiel2,
- Sandra Puentes1,
- Kensuke Owari1,
- Terumi Nakatani1,
- Naotake Nogami1,
- Kazuhiro Yamamoto4,
- Satoru Noguchi5,
- Takahiro Yonekawa5,
- Yoko Tanaka3,
- Naoko Fujita1,
- Hikaru Suzuki1,
- Hisae Kikuchi2,
- Shu Aizawa2,
- Seiichi Nagano6,
- Daisuke Yamada2,
- Ichizo Nishino5,
- Noritaka Ichinohe7,
- Keiji Wada2,
- Shinichi Kohsaka8,
- Yoshitaka Nagai2 and
- Kazuhiko Seki1
- 1Department of Neurophysiology, National Institute of Neuroscience National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan
- 2Department of Degenerative Neurological Diseases, National Institute of Neuroscience National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan
- 3Department of Pathology and Laboratory Medicine, National Institute of Neuroscience National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan
- 4Division of Laboratory Animals Resources, National Institute of Neuroscience National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan
- 5Department of Neuromuscular Research, National Institute of Neuroscience National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan
- 6Department of Peripheral Nervous System Research, National Institute of Neuroscience National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan
- 7Department of Ultrastructural Research, National Institute of Neuroscience National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan
- 8Department of Neurochemistry, National Institute of Neuroscience National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan
- Correspondence should be addressed to one of the following: Ikuo Tomioka, Institute for Biomedical Science, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, Japan. E-mail: tomioka{at}shinshu-u.ac.jp; or Yoshitaka Nagai, Department of Neurotherapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: nagai{at}neurother.med.osaka-u.ac.jp; or Kazuhiko Seki, Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashimachi, Kodaira, Tokyo 187-8502, Japan. E-mail: seki{at}ncnp.go.jp.
Author contributions
Author contributions: I.T., K.Y., K.W., S.K., Y.N., and K.S. designed research; I.T., H.I., E.N.M., H.H.M., O.T., Y.S., H.A.P., S.P., K.O., T.N., N.N., K.Y., S. Noguchi, T.Y., Y.T., N.F., H.S., H.K., S.A., S. Nagano, D.Y., and N.I. performed research; I.T. contributed unpublished reagents/analytic tools; I.T., H.I., E.N.M., H.H.M., O.T., Y.S., H.A.P., S.P., K.O., T.N., K.Y., S. Noguchi, T.Y., N.F., S.A., I.N., Y.N., and K.S. analyzed data; I.T., H.I., E.N.M., Y.S., H.A.P., S. Noguchi, Y.N., and K.S. wrote the paper.
Disclosures
The authors declare no competing financial interests.
This work was supported in part by Intramural Research Grants for Neurological and Psychiatric Disorders from the National Center of Neurology and Psychiatry [23-9, 26-11 to K.S., Y.N., and I.T.]; a Health Labour Sciences Research Grant for Research on Development of New Drugs from the Ministry of Health, Labour and Welfare, Japan and the Japan Agency for Medical Research and Development [26-005 to K.S., Y.N., and I.T.]; Grants-in-Aid for Challenging Exploratory Research from the Japan Society for the Promotion of Science, Japan [26670446 to Y.N.]; Grants-in-Aid for Young Scientists (B) from the Japan Society for the Promotion of Science, Japan [26870884 to I.T.]; a grant from Core Research for Evolutional Science and Technology (CREST) of the Japan Science and Technology Agency to Y.N; a research grant from the ALS “Inochi no Iro” Foundation to I.T.; and a research grant from the Takeda Science Foundation to I.T.
Funding
National Center of Neurology and Psychiatry
23-9Ministry of Health, Labour and Welfare (MHLW)
501100003478; 26-005Japan Society for the Promotion of Science (JSPS)
501100001691; 26670446Japan Society for the Promotion of Science (JSPS)
501100001691; 26870884Japan Science and Technology Agency (JST)
501100002241Inochi no Iro Foundation
Takeda Science Foundation
100007449
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